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phtpp  (MedChemExpress)


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    Structured Review

    MedChemExpress phtpp
    E2 exerted an antisenescence effect via ERα, <t>not</t> <t>ERβ</t> or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, <t>PHTPP</t> and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.
    Phtpp, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 43 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phtpp/product/MedChemExpress
    Average 94 stars, based on 43 article reviews
    phtpp - by Bioz Stars, 2026-03
    94/100 stars

    Images

    1) Product Images from "17‐β‐Estradiol Protects Chondrocytes From Senescence and Ameliorates Osteoarthritis Progression via ERα ‐ AKT ‐ FOXO4 Pathway"

    Article Title: 17‐β‐Estradiol Protects Chondrocytes From Senescence and Ameliorates Osteoarthritis Progression via ERα ‐ AKT ‐ FOXO4 Pathway

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.71018

    E2 exerted an antisenescence effect via ERα, not ERβ or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, PHTPP and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.
    Figure Legend Snippet: E2 exerted an antisenescence effect via ERα, not ERβ or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, PHTPP and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.

    Techniques Used: Western Blot, Expressing, Transfection



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    E2 exerted an antisenescence effect via ERα, <t>not</t> <t>ERβ</t> or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, <t>PHTPP</t> and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.
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    E2 exerted an antisenescence effect via ERα, <t>not</t> <t>ERβ</t> or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, <t>PHTPP</t> and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.
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    E2 exerted an antisenescence effect via ERα, <t>not</t> <t>ERβ</t> or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, <t>PHTPP</t> and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.
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    Image Search Results


    E2 exerted an antisenescence effect via ERα, not ERβ or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, PHTPP and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: 17‐β‐Estradiol Protects Chondrocytes From Senescence and Ameliorates Osteoarthritis Progression via ERα ‐ AKT ‐ FOXO4 Pathway

    doi: 10.1111/jcmm.71018

    Figure Lengend Snippet: E2 exerted an antisenescence effect via ERα, not ERβ or GPER. Normal chondrocytes were used in this section. (a) Western blotting was performed to assess the expression of p16 and p21 after treatment with several combinations of IL‐6, E2, TPBM, PHTPP and G‐15 ( n = 4). (b) The relative levels of p16 and p21 in the six groups are shown. (c) Western blotting was conducted to assess the expression of ERα, p16 and p21 after treatment with IL‐6 and/or E2 with or without ERα‐specific siRNA transfection ( n = 4). (d–g) The relative levels of ERα (e), p16 (f) and p21 (g) in the five groups are presented. One‐way analysis of variance (ANOVA) was applied, followed by Bonferroni's post hoc test for multiple comparisons. A p ‐value of less than 0.05 was considered statistically significant. All the data are presented as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.

    Article Snippet: To block ERβ, 1 μM PHTPP (MCE, HY‐103456) was used for 24 h. To block GPER, 1 μM G15 (MCE, HY‐103449) was used for 48 h [ , , , ].

    Techniques: Western Blot, Expressing, Transfection