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pfus  (ATCC)


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    ATCC pfus
    Pfus, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 431 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pfus/product/ATCC
    Average 99 stars, based on 431 article reviews
    pfus - by Bioz Stars, 2026-06
    99/100 stars

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    Integrated mechanistic framework of pFUS-mediated seizure suppression. pFUS modulates neural activity through dual cellular pathways: the preferential activation of GABAergic interneurons and astrocytic mechano-transduction, leading to disrupted hypersynchrony and restored excitation–inhibition balance. These cellular effects propagate to network-level modulation, characterized by desynchronization and increased signal complexity. Ultimately, these processes drive system-level outcomes, including acute seizure reduction and long-term benefits mediated by neuroprotection.

    Journal: Neurotherapeutics

    Article Title: Pulsed focused ultrasound for seizure suppression: Mechanisms, models, and clinical translation

    doi: 10.1016/j.neurot.2026.e00920

    Figure Lengend Snippet: Integrated mechanistic framework of pFUS-mediated seizure suppression. pFUS modulates neural activity through dual cellular pathways: the preferential activation of GABAergic interneurons and astrocytic mechano-transduction, leading to disrupted hypersynchrony and restored excitation–inhibition balance. These cellular effects propagate to network-level modulation, characterized by desynchronization and increased signal complexity. Ultimately, these processes drive system-level outcomes, including acute seizure reduction and long-term benefits mediated by neuroprotection.

    Article Snippet: 3 , KA chronic epilepsy C57BL/6 mice (N = 14)/KA injection at CA3 region , MI: 0.37, I SPTA : 1.13 W/cm 2 (with skull attenuation), DC: 50 %, SD: 30 s, one session , pFUS-seizure suppression correlated with restoration of neural signal complexity: Approximate entropy increased (delta and theta band); largest lyapunov exponent increased. pFUS restored normal nonlinear dynamics , [ ] .

    Techniques: Activity Assay, Activation Assay, Transduction, Inhibition