Journal: Experimental neurology
Article Title: Daily acute intermittent hypoxia elicits age & sex-dependent changes in molecules regulating phrenic motor plasticity
doi: 10.1016/j.expneurol.2025.115240
Figure Lengend Snippet: In young males, dAIH exposure significantly reduced Q pathway associated 5HT2A receptor expression (Panel A). In young females, dAIH significantly reduced S to Q cross talk molecules – p38Map kinase β ( Mapk11 ) and phosphodiesterase ( Pde4b ) expression. Reduced phosphodiesterase expression could indirectly increase PKA or EPAC activity which could in turn increase S to Q inhibition (Panel B). In middle aged males, no significant effect of dAIH exposure was observed (Panel C). In contrast widespread gene expression changes with dAIH exposure were observed in middle aged females. dAIH reduced expression of 5HT2B and A2A receptor, Q to S cross talk molecules–PKCδ ( Prkcd ) and NADPH-p47 ( Ncf1 ), S to Q cross-talk molecules phosphodiesterase 4b, and fractalkine ( Cx3cl1 ) (Panel D).
Article Snippet: phosphodiesterase 4B , pde4b , S to Q crosstalk , Rn00566785_m1 , 70.
Techniques: Expressing, Activity Assay, Inhibition, Gene Expression