Journal: JACC: Basic to Translational Science
Article Title: Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF
doi: 10.1016/j.jacbts.2025.04.011
Figure Lengend Snippet: Survodutide and DATS Attenuate Hepatic Lipid Content and Cardiac Fibrosis in ZSF1 Obese Rat HFpEF Model Representative images of hepatic lipid accumulation stained with Oil Red O, and representative images of cardiac fibrosis stained with Masson’s Trichrome and fast green counterstaining and respective quantification. Hepatic lipid content expressed as % area in bar graph. Cardiac interstitial and perivascular fibrosis expressed as % collagen fraction in bar graphs. Data were analyzed with 1-way analysis of variance followed by Tukey's post hoc test. Data are presented as mean ± SEM. # P < 0.05, and ∗ P < 0.05 vs control. Abbreviations as in .
Article Snippet: Animals were randomly assigned to 3 groups: vehicle (saline, n = 6), Survodutide (MedChemExpress LLC, USA, 30 nmol/kg, subcutaneously, biweekly, n = 8), or a combination of Survodutide and DATS (Cayman Chemical, USA, 150 μmol/L/kg, intraperitoneally, daily, n = 8).
Techniques: Staining, Control