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simeprevir  (Janssen)

 
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    Janssen simeprevir
    Simeprevir, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/simeprevir/product/Janssen
    Average 86 stars, based on 1 article reviews
    simeprevir - by Bioz Stars, 2026-06
    86/100 stars

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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Simeprevir, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    simeprevir  (Selleck Chemicals)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Simeprevir, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    simeprevir  (Janssen)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Simeprevir, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/simeprevir/product/Janssen
    Average 86 stars, based on 1 article reviews
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    tmc435 simeprevir nda type  (Janssen)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Tmc435 Simeprevir Nda Type, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    simeprevir review number  (Janssen)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Simeprevir Review Number, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    simeprevir date  (Janssen)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Simeprevir Date, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    nda 205123 simeprevir pbpk review physiological  (Janssen)
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    Janssen nda 205123 simeprevir pbpk review physiological
    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Nda 205123 Simeprevir Pbpk Review Physiological, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    olysio  (Janssen)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Olysio, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    olysio  (Gilead Sciences)
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    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between <t>Simeprevir</t> and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1
    Olysio, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between Simeprevir and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1

    Journal: Journal of translational medicine

    Article Title: Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.

    doi: 10.1186/s12967-025-06086-1

    Figure Lengend Snippet: Fig. 9 Structure-based virtual screen of SLC7A1 (A) Schematic diagram of the workflow for structure-based virtual screening. (B) The predicted 3D structure of SLC7A1 by AlphaFold2. (C) Predicted aligned error of the SLC7A1 3D model. (D) Overall model quality of the SLC7A1 3D analyzed by ProSA- Web. (E) The calculated binding mode between Paritaprevie and SLC7A1. (F) The calculated binding mode between Cepharanthine and SLC7A1. (G) The calculated binding mode between Midostaurin and SLC7A1. (H) The calculated binding mode between Ledipasvir and SLC7A1. (I) The calculated binding mode between Alcuronium and SLC7A1. (J) The calculated binding mode between Venetoclax and SLC7A1. (K) The calculated binding mode between Eltrombopag and SLC7A1. (L) The calculated binding mode between Simeprevir and SLC7A1. (M) The calculated binding mode between Vaprisol and SLC7A1. (N) The calculated binding mode between Glecaprevir and SLC7A1

    Article Snippet: Drugs including Paritaprevir (HY-12594), Cepharanthine (HY-N6972), Midostaurin (HY-10230), Ledipasvir (HY-15602), Alcuronium (HY106707), Venetoclax (HY-15531), Eltrombopag (HY15306), Simeprevir (HY-10241), Vaprisol (HY-18347 A) and Glecaprevir (HY-17634) were purchased from MedChemExpress.

    Techniques: Binding Assay

    Fig. 10 Cepharanthine is a potential targeted inhibitor of SLC7A1. (A) Inhibition of arginine uptake in 143B cells by 10 drugs. (B) IC50 analysis of Parita previr, Cepharanthine, Eltrombopag, and Simeprevir. (C) CETSA showing the binding of CPE to SLC7A1 protein. (D) Arginine uptake in 143B cells treated with 0, 2, and 5 µM CPE. (E) CCK8 assay evaluating the proliferation of 143B cells treated with 0, 2, and 5 µM CPE. (F) Schematic of conditioned medium production from CPE -pretreated 143B cells. Cells were treated with 0, 2, or 5 µM CPE, followed by medium replacement after 24 h. After an additional 24- hour incubation, the conditioned medium was collected. This medium was used to culture THP1-induced macrophages for 48 h before flow cytometry analysis. (G) Flow cytometry analysis of CD206 expression in macrophages. (H) Flow cytometry analysis of CD86 expression in macrophages

    Journal: Journal of translational medicine

    Article Title: Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.

    doi: 10.1186/s12967-025-06086-1

    Figure Lengend Snippet: Fig. 10 Cepharanthine is a potential targeted inhibitor of SLC7A1. (A) Inhibition of arginine uptake in 143B cells by 10 drugs. (B) IC50 analysis of Parita previr, Cepharanthine, Eltrombopag, and Simeprevir. (C) CETSA showing the binding of CPE to SLC7A1 protein. (D) Arginine uptake in 143B cells treated with 0, 2, and 5 µM CPE. (E) CCK8 assay evaluating the proliferation of 143B cells treated with 0, 2, and 5 µM CPE. (F) Schematic of conditioned medium production from CPE -pretreated 143B cells. Cells were treated with 0, 2, or 5 µM CPE, followed by medium replacement after 24 h. After an additional 24- hour incubation, the conditioned medium was collected. This medium was used to culture THP1-induced macrophages for 48 h before flow cytometry analysis. (G) Flow cytometry analysis of CD206 expression in macrophages. (H) Flow cytometry analysis of CD86 expression in macrophages

    Article Snippet: Drugs including Paritaprevir (HY-12594), Cepharanthine (HY-N6972), Midostaurin (HY-10230), Ledipasvir (HY-15602), Alcuronium (HY106707), Venetoclax (HY-15531), Eltrombopag (HY15306), Simeprevir (HY-10241), Vaprisol (HY-18347 A) and Glecaprevir (HY-17634) were purchased from MedChemExpress.

    Techniques: Inhibition, Binding Assay, CCK-8 Assay, Incubation, Flow Cytometry, Expressing