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lncrna cyrano oip5 as1  (Cyrano Sciences Inc)
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A Schematic representation of the genomic locus of lncRNA <t>Cyrano/OIP5-AS1.</t> Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .
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lncrna cyrano oip5 as1 across cells  (Cyrano Sciences Inc)
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A Schematic representation of the genomic locus of lncRNA <t>Cyrano/OIP5-AS1.</t> Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .
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oip5 as1 targeted nanotherapeutics  (Nanotherapeutics)
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A Schematic representation of the genomic locus of lncRNA <t>Cyrano/OIP5-AS1.</t> Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .
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A Schematic representation of the genomic locus of lncRNA <t>Cyrano/OIP5-AS1.</t> Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .
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gene exp oip5 as1 hs03677189 g1  (Thermo Fisher)
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Thermo Fisher gene exp oip5 as1 hs03677189 g1
A Schematic representation of the genomic locus of lncRNA <t>Cyrano/OIP5-AS1.</t> Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .
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oip5 as1  (Exosome Diagnostics)
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Exosomal transfer <t>of</t> <t>OIP5-AS1</t> from resistant cells enhances SOX9 expression and Sunitinib resistance in sensitive GIST cells.
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A Schematic representation of the genomic locus of lncRNA Cyrano/OIP5-AS1. Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .

Journal: Nature Communications

Article Title: The history and function of a circular RNA

doi: 10.1038/s41467-026-71822-0

Figure Lengend Snippet: A Schematic representation of the genomic locus of lncRNA Cyrano/OIP5-AS1. Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .

Article Snippet: B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1.

Techniques: Sequencing, Expressing, RNA Expression, Single Cell

A Schematic representation of the genomic locus of lncRNA Cyrano/OIP5-AS1. Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .

Journal: Nature Communications

Article Title: The history and function of a circular RNA

doi: 10.1038/s41467-026-71822-0

Figure Lengend Snippet: A Schematic representation of the genomic locus of lncRNA Cyrano/OIP5-AS1. Exon 3 contains a single miR-7 perfect complementarity site (pink), which triggers miR-7 TDMD. Additionally, one of the several Cyrano conserved regions, a 300nt sequence (purple) flanking the miR-7 biding site emerged in vertebrates from Xenopus to Human, but is not present in zebrafish . B Evolutionary conservation of lncRNA Cyrano/OIP5-AS1. Phylogeny of several animal groups reflecting the expression of Cyrano/OIP5-AS1 from zebrafish to human. Conservation of 300nt sequence (purple) containing miR-7 biding site (red). C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues. Indicated is the relative expression of Cyrano across samples from high (purple) to low (gray) Left: brain region specific (cortex, hippocampus, hypothalamus, pituitary gland; Allen Brain Atlas). Middle: neuronal-type specific (inhibitory, excitatory, granular). D Normalized abundance of the Cyrano sequences across matched human and mouse organ systems (nervous, blood/immune, respiratory, digestive, urinary and skeletal). Expression was estimated from raw reads by counting exact k-mer matches to the probe sequences in each single-cell or spatial dataset (Rajewsky lab, unpublished sequence-search index). Values are scaled to the total number of informative k-mers per cell and sample. Expression units are species-normalized pseudocounts (scaled per 10⁶ k-mers per cell). Within the nervous system, the same approach resolves region- and cell-type–specific patterns for neuronal and glial subclasses of human and mouse . Datasets: Human Cell Atlas single-cell collections released up to 2024; Human Adult Brain Cell Atlas ; Mouse Brain Cell Atlas ; Tabula Muris (Tabula Muris Consortium 2018, 2020). Created in BioRender. https://BioRender.com/3it2qak .

Article Snippet: C Relative RNA expression of lncRNA Cyrano/OIP5-AS1 across cells and tissues.

Techniques: Sequencing, Expressing, RNA Expression, Single Cell

Exosomal transfer of OIP5-AS1 from resistant cells enhances SOX9 expression and Sunitinib resistance in sensitive GIST cells.

Journal: Cancer Biology & Therapy

Article Title: Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9

doi: 10.1080/15384047.2025.2522543

Figure Lengend Snippet: Exosomal transfer of OIP5-AS1 from resistant cells enhances SOX9 expression and Sunitinib resistance in sensitive GIST cells.

Article Snippet: Exosome-mediated transfer of OIP5-AS1 induced heightened proliferation and invasion of GIST cells, culminating in the induction of chemoresistance to sunitinib through the miR-145/SOX9 axis.

Techniques: Expressing

Elevated OIP5-AS1, SOX9, and suppressed miR-145 enhanced the chemosensitivity in GIST1882 cells.

Journal: Cancer Biology & Therapy

Article Title: Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9

doi: 10.1080/15384047.2025.2522543

Figure Lengend Snippet: Elevated OIP5-AS1, SOX9, and suppressed miR-145 enhanced the chemosensitivity in GIST1882 cells.

Article Snippet: Exosome-mediated transfer of OIP5-AS1 induced heightened proliferation and invasion of GIST cells, culminating in the induction of chemoresistance to sunitinib through the miR-145/SOX9 axis.

Techniques:

OIP5-AS1 targeted miR-145/SOX9 axis and regulated chemosensitivity of GIST-882 cells.

Journal: Cancer Biology & Therapy

Article Title: Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9

doi: 10.1080/15384047.2025.2522543

Figure Lengend Snippet: OIP5-AS1 targeted miR-145/SOX9 axis and regulated chemosensitivity of GIST-882 cells.

Article Snippet: Exosome-mediated transfer of OIP5-AS1 induced heightened proliferation and invasion of GIST cells, culminating in the induction of chemoresistance to sunitinib through the miR-145/SOX9 axis.

Techniques:

Exosome-delivered si-OIP5-AS1 increased sunitinib sensitivity.

Journal: Cancer Biology & Therapy

Article Title: Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9

doi: 10.1080/15384047.2025.2522543

Figure Lengend Snippet: Exosome-delivered si-OIP5-AS1 increased sunitinib sensitivity.

Article Snippet: Exosome-mediated transfer of OIP5-AS1 induced heightened proliferation and invasion of GIST cells, culminating in the induction of chemoresistance to sunitinib through the miR-145/SOX9 axis.

Techniques: