Journal: Frontiers in Immunology
Article Title: Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions
doi: 10.3389/fimmu.2025.1589959
Figure Lengend Snippet: Analysis of microvascular parameters. Visualization of (A) PBR, (B) capillary density and (C) MVHS in Healthy volunteers and patients, respectively. (D) Scatter dot plots and simple linear regression (slope) with 95% confidence intervals of capillary density plotted against PBR (D4 to 25µm) in patients. The dotted lines represent the median values of capillary density and PBR, respectively. (E, F) show the ranked Spearman's correlation coefficients (ρ) of 125 mononuclear blood cell parameters with the perfused boundary region (PBR) and capillary density, respectively. Positive and negative correlations are shown in both panels. The colored bars represent significant correlations: orange for parameters significantly correlated with PBR, blue for those significantly correlated with capillary density, green for parameters significantly correlated with both PBR and capillary density, and grey for those with no significant correlation. (G – J) Insets below each panel highlight specific cell types or parameters with the most significant correlations. (K) Venn diagram illustrating associations of mononuclear blood cell parameters with PBR and/or capillary density.
Article Snippet: The Microvascular Health Score (MVHS; in points) is a composite metric, which has been previously presented in detail ( ).
Techniques: