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mlr-1023  (Millipore)


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    Structured Review

    Millipore mlr-1023
    Reactivation of Src signaling in NECTIN4-inhibited angiosarcoma cells. Control or NECTIN4 siRNA-transfected HAMON and ISO-HAS-B cells were further treated with <t>MLR-1023</t> and assessed for cell proliferation and angiogenesis. ( A,B ) Mean (± SD) number of viable cells in siRNA-transfected, DMSO (0.1%) or MLR-1023 (1 μM)-treated ( A ) HAMON and ( B ) ISO-HAS-B cells, as detected by the CCK-8 assay. Data show fold changes relative to Day 0. Experiments were repeated three times, with three wells used for each condition. Significance of differences was calculated between NECTIN4-siRNA transfected DMSO-treated cells and NECTIN4-siRNA transfected MLR-1023-treated cells. ( C,D ) Representative images of angiogenesis in ( C ) HAMON and ( D ) ISO-HAS-B cells. Scale bars = 0.5 mm. ( E,F ) Number of tubules per 1 cm 2 , tubule length per 1 cm 2 , and the number of junctions per 1 cm 2 of ( E ) HAMON and ( F ) ISO-HAS-B cells in the angiogenesis assay. Data are the mean ± SD of three independent experiments. ** P < 0.01, and *** P < 0.001.
    Mlr 1023, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mlr-1023/mlr+1023/pmc08901754-258-11-12
    Average 90 stars, based on 1 article reviews
    mlr-1023 - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma"

    Article Title: Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma

    Journal: Scientific Reports

    doi: 10.1038/s41598-022-07727-x

    Reactivation of Src signaling in NECTIN4-inhibited angiosarcoma cells. Control or NECTIN4 siRNA-transfected HAMON and ISO-HAS-B cells were further treated with MLR-1023 and assessed for cell proliferation and angiogenesis. ( A,B ) Mean (± SD) number of viable cells in siRNA-transfected, DMSO (0.1%) or MLR-1023 (1 μM)-treated ( A ) HAMON and ( B ) ISO-HAS-B cells, as detected by the CCK-8 assay. Data show fold changes relative to Day 0. Experiments were repeated three times, with three wells used for each condition. Significance of differences was calculated between NECTIN4-siRNA transfected DMSO-treated cells and NECTIN4-siRNA transfected MLR-1023-treated cells. ( C,D ) Representative images of angiogenesis in ( C ) HAMON and ( D ) ISO-HAS-B cells. Scale bars = 0.5 mm. ( E,F ) Number of tubules per 1 cm 2 , tubule length per 1 cm 2 , and the number of junctions per 1 cm 2 of ( E ) HAMON and ( F ) ISO-HAS-B cells in the angiogenesis assay. Data are the mean ± SD of three independent experiments. ** P < 0.01, and *** P < 0.001.
    Figure Legend Snippet: Reactivation of Src signaling in NECTIN4-inhibited angiosarcoma cells. Control or NECTIN4 siRNA-transfected HAMON and ISO-HAS-B cells were further treated with MLR-1023 and assessed for cell proliferation and angiogenesis. ( A,B ) Mean (± SD) number of viable cells in siRNA-transfected, DMSO (0.1%) or MLR-1023 (1 μM)-treated ( A ) HAMON and ( B ) ISO-HAS-B cells, as detected by the CCK-8 assay. Data show fold changes relative to Day 0. Experiments were repeated three times, with three wells used for each condition. Significance of differences was calculated between NECTIN4-siRNA transfected DMSO-treated cells and NECTIN4-siRNA transfected MLR-1023-treated cells. ( C,D ) Representative images of angiogenesis in ( C ) HAMON and ( D ) ISO-HAS-B cells. Scale bars = 0.5 mm. ( E,F ) Number of tubules per 1 cm 2 , tubule length per 1 cm 2 , and the number of junctions per 1 cm 2 of ( E ) HAMON and ( F ) ISO-HAS-B cells in the angiogenesis assay. Data are the mean ± SD of three independent experiments. ** P < 0.01, and *** P < 0.001.

    Techniques Used: Transfection, CCK-8 Assay, Angiogenesis Assay

    Related Articles

    Concentration Assay:

    Article Title: Oxidant signaling mediated by Nox2 in Neutrophils promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage
    Article Snippet: For pharmacological Lyn activation, the Lyn activator, MLR-1023 (Sigma) or DMSO only was used.

    Article Title: Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma
    Article Snippet: MMAE (ChemScene, Deerpark, NJ; CS-0837), LY294002 (Abcam; ab120243), dasatinib (Abcam; ab142050), MLR-1023 (Sigma-Aldrich, St. Louis, MO; SML0361), and cabozantinib (Selleck Biotech, Tokyo, Japan; BMS-907351) were dissolved in DMSO (Sigma-Aldrich; 07-4860-5), which was also used as the vehicle control (final concentration 0.1% DMSO).

    Transfection:

    Article Title: Oxidant signaling mediated by Nox2 in Neutrophils promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage
    Article Snippet: For pharmacological Lyn activation, the Lyn activator, MLR-1023 (Sigma) or DMSO only was used.

    Article Title: Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma
    Article Snippet: MMAE (ChemScene, Deerpark, NJ; CS-0837), LY294002 (Abcam; ab120243), dasatinib (Abcam; ab142050), MLR-1023 (Sigma-Aldrich, St. Louis, MO; SML0361), and cabozantinib (Selleck Biotech, Tokyo, Japan; BMS-907351) were dissolved in DMSO (Sigma-Aldrich; 07-4860-5), which was also used as the vehicle control (final concentration 0.1% DMSO).

    CCK-8 Assay:

    Article Title: Oxidant signaling mediated by Nox2 in Neutrophils promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage
    Article Snippet: For pharmacological Lyn activation, the Lyn activator, MLR-1023 (Sigma) or DMSO only was used.

    Article Title: Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma
    Article Snippet: MMAE (ChemScene, Deerpark, NJ; CS-0837), LY294002 (Abcam; ab120243), dasatinib (Abcam; ab142050), MLR-1023 (Sigma-Aldrich, St. Louis, MO; SML0361), and cabozantinib (Selleck Biotech, Tokyo, Japan; BMS-907351) were dissolved in DMSO (Sigma-Aldrich; 07-4860-5), which was also used as the vehicle control (final concentration 0.1% DMSO).

    Angiogenesis Assay:

    Article Title: Oxidant signaling mediated by Nox2 in Neutrophils promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage
    Article Snippet: For pharmacological Lyn activation, the Lyn activator, MLR-1023 (Sigma) or DMSO only was used.

    Article Title: Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma
    Article Snippet: MMAE (ChemScene, Deerpark, NJ; CS-0837), LY294002 (Abcam; ab120243), dasatinib (Abcam; ab142050), MLR-1023 (Sigma-Aldrich, St. Louis, MO; SML0361), and cabozantinib (Selleck Biotech, Tokyo, Japan; BMS-907351) were dissolved in DMSO (Sigma-Aldrich; 07-4860-5), which was also used as the vehicle control (final concentration 0.1% DMSO).



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    mlr-1023  (Millipore)
    90
    Millipore mlr-1023
    Reactivation of Src signaling in NECTIN4-inhibited angiosarcoma cells. Control or NECTIN4 siRNA-transfected HAMON and ISO-HAS-B cells were further treated with <t>MLR-1023</t> and assessed for cell proliferation and angiogenesis. ( A,B ) Mean (± SD) number of viable cells in siRNA-transfected, DMSO (0.1%) or MLR-1023 (1 μM)-treated ( A ) HAMON and ( B ) ISO-HAS-B cells, as detected by the CCK-8 assay. Data show fold changes relative to Day 0. Experiments were repeated three times, with three wells used for each condition. Significance of differences was calculated between NECTIN4-siRNA transfected DMSO-treated cells and NECTIN4-siRNA transfected MLR-1023-treated cells. ( C,D ) Representative images of angiogenesis in ( C ) HAMON and ( D ) ISO-HAS-B cells. Scale bars = 0.5 mm. ( E,F ) Number of tubules per 1 cm 2 , tubule length per 1 cm 2 , and the number of junctions per 1 cm 2 of ( E ) HAMON and ( F ) ISO-HAS-B cells in the angiogenesis assay. Data are the mean ± SD of three independent experiments. ** P < 0.01, and *** P < 0.001.
    Mlr 1023, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mlr-1023/mlr+1023/pmc08901754-258-11-12
    Average 90 stars, based on 1 article reviews
    mlr-1023 - by Bioz Stars, 2026-09
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    Image Search Results


    Reactivation of Src signaling in NECTIN4-inhibited angiosarcoma cells. Control or NECTIN4 siRNA-transfected HAMON and ISO-HAS-B cells were further treated with MLR-1023 and assessed for cell proliferation and angiogenesis. ( A,B ) Mean (± SD) number of viable cells in siRNA-transfected, DMSO (0.1%) or MLR-1023 (1 μM)-treated ( A ) HAMON and ( B ) ISO-HAS-B cells, as detected by the CCK-8 assay. Data show fold changes relative to Day 0. Experiments were repeated three times, with three wells used for each condition. Significance of differences was calculated between NECTIN4-siRNA transfected DMSO-treated cells and NECTIN4-siRNA transfected MLR-1023-treated cells. ( C,D ) Representative images of angiogenesis in ( C ) HAMON and ( D ) ISO-HAS-B cells. Scale bars = 0.5 mm. ( E,F ) Number of tubules per 1 cm 2 , tubule length per 1 cm 2 , and the number of junctions per 1 cm 2 of ( E ) HAMON and ( F ) ISO-HAS-B cells in the angiogenesis assay. Data are the mean ± SD of three independent experiments. ** P < 0.01, and *** P < 0.001.

    Journal: Scientific Reports

    Article Title: Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma

    doi: 10.1038/s41598-022-07727-x

    Figure Lengend Snippet: Reactivation of Src signaling in NECTIN4-inhibited angiosarcoma cells. Control or NECTIN4 siRNA-transfected HAMON and ISO-HAS-B cells were further treated with MLR-1023 and assessed for cell proliferation and angiogenesis. ( A,B ) Mean (± SD) number of viable cells in siRNA-transfected, DMSO (0.1%) or MLR-1023 (1 μM)-treated ( A ) HAMON and ( B ) ISO-HAS-B cells, as detected by the CCK-8 assay. Data show fold changes relative to Day 0. Experiments were repeated three times, with three wells used for each condition. Significance of differences was calculated between NECTIN4-siRNA transfected DMSO-treated cells and NECTIN4-siRNA transfected MLR-1023-treated cells. ( C,D ) Representative images of angiogenesis in ( C ) HAMON and ( D ) ISO-HAS-B cells. Scale bars = 0.5 mm. ( E,F ) Number of tubules per 1 cm 2 , tubule length per 1 cm 2 , and the number of junctions per 1 cm 2 of ( E ) HAMON and ( F ) ISO-HAS-B cells in the angiogenesis assay. Data are the mean ± SD of three independent experiments. ** P < 0.01, and *** P < 0.001.

    Article Snippet: MMAE (ChemScene, Deerpark, NJ; CS-0837), LY294002 (Abcam; ab120243), dasatinib (Abcam; ab142050), MLR-1023 (Sigma-Aldrich, St. Louis, MO; SML0361), and cabozantinib (Selleck Biotech, Tokyo, Japan; BMS-907351) were dissolved in DMSO (Sigma-Aldrich; 07-4860-5), which was also used as the vehicle control (final concentration 0.1% DMSO).

    Techniques: Transfection, CCK-8 Assay, Angiogenesis Assay