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non targeted dub loaded liposomes (MedChemExpress)

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MedChemExpress non targeted dub loaded liposomes
$Establishment <t>of</t> <t>DUB-loaded</t> bone-targeted liposomal delivery system. ( A ) Representative images and quantitative analysis of mineralized nodule formation via Alizarin Red S (ARS) staining in primary BMSCs for the effect of DUB@Lip on osteogenesis differentiation under conditions of 10 μM Dex. ( B ) RT-qPCR for the expression of osteogenesis-related genes in primary BMSCs of different groups. ( C-D ) In vitro cellular uptake assay of IR-780-labeled DUB@Lip liposomes in primary BMSCs by confocal microscopy and flow cytometry. ( E-F ) Evaluation of bone-targeting capacity and pharmacokinetic analysis of DUB@Lip and DUB@TLip via ex vivo fluorescence imaging. ( G-H ) Representative reconstructed images and quantification for Tb.BV/TV, Tb.N, Tb.Th, Tb.Sp, and Ct.Th in femora in mice of different groups by Micro-CT. ( I ) H&E staining and quantification for trabecular bone area in distal femora in mice of different groups. ( J ) Masson staining and quantification for collagen deposition fraction (collagen area/trabecular bone area) in distal femora in mice of different groups. n = 4 independent repeats by using different biological samples in each group for in vitro experiments, or 8 mice per group for in vivo assays. Data were means ± s.e.m. ns p > 0.05, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001 by one-way ANOVA. Scale bars: 200 μm (A-B), 2 mm (G left & right bottom), 1 mm (G right top), and 100 μm (I-J).$
Non Targeted Dub Loaded Liposomes, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 40 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/liposomes/pmc13085024-163-2-15?v=MedChemExpress
Average 95 stars, based on 40 article reviews

non targeted dub loaded liposomes - by Bioz Stars, 2026-07

95/100 stars

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1) Product Images from "Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis"

Article Title: Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis

Journal: Bioactive Materials

doi: 10.1016/j.bioactmat.2026.03.062

$Establishment of DUB-loaded bone-targeted liposomal delivery system. ( A ) Representative images and quantitative analysis of mineralized nodule formation via Alizarin Red S (ARS) staining in primary BMSCs for the effect of DUB@Lip on osteogenesis differentiation under conditions of 10 μM Dex. ( B ) RT-qPCR for the expression of osteogenesis-related genes in primary BMSCs of different groups. ( C-D ) In vitro cellular uptake assay of IR-780-labeled DUB@Lip liposomes in primary BMSCs by confocal microscopy and flow cytometry. ( E-F ) Evaluation of bone-targeting capacity and pharmacokinetic analysis of DUB@Lip and DUB@TLip via ex vivo fluorescence imaging. ( G-H ) Representative reconstructed images and quantification for Tb.BV/TV, Tb.N, Tb.Th, Tb.Sp, and Ct.Th in femora in mice of different groups by Micro-CT. ( I ) H&E staining and quantification for trabecular bone area in distal femora in mice of different groups. ( J ) Masson staining and quantification for collagen deposition fraction (collagen area/trabecular bone area) in distal femora in mice of different groups. n = 4 independent repeats by using different biological samples in each group for in vitro experiments, or 8 mice per group for in vivo assays. Data were means ± s.e.m. ns p > 0.05, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001 by one-way ANOVA. Scale bars: 200 μm (A-B), 2 mm (G left & right bottom), 1 mm (G right top), and 100 μm (I-J).$
Figure Legend Snippet: Establishment of DUB-loaded bone-targeted liposomal delivery system. ( A ) Representative images and quantitative analysis of mineralized nodule formation via Alizarin Red S (ARS) staining in primary BMSCs for the effect of DUB@Lip on osteogenesis differentiation under conditions of 10 μM Dex. ( B ) RT-qPCR for the expression of osteogenesis-related genes in primary BMSCs of different groups. ( C-D ) In vitro cellular uptake assay of IR-780-labeled DUB@Lip liposomes in primary BMSCs by confocal microscopy and flow cytometry. ( E-F ) Evaluation of bone-targeting capacity and pharmacokinetic analysis of DUB@Lip and DUB@TLip via ex vivo fluorescence imaging. ( G-H ) Representative reconstructed images and quantification for Tb.BV/TV, Tb.N, Tb.Th, Tb.Sp, and Ct.Th in femora in mice of different groups by Micro-CT. ( I ) H&E staining and quantification for trabecular bone area in distal femora in mice of different groups. ( J ) Masson staining and quantification for collagen deposition fraction (collagen area/trabecular bone area) in distal femora in mice of different groups. n = 4 independent repeats by using different biological samples in each group for in vitro experiments, or 8 mice per group for in vivo assays. Data were means ± s.e.m. ns p > 0.05, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001 by one-way ANOVA. Scale bars: 200 μm (A-B), 2 mm (G left & right bottom), 1 mm (G right top), and 100 μm (I-J).

Techniques Used: Staining, Quantitative RT-PCR, Expressing, In Vitro, Labeling, Liposomes, Confocal Microscopy, Flow Cytometry, Ex Vivo, Fluorescence, Imaging, Micro-CT, In Vivo

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Journal: Bioactive Materials

doi: 10.1016/j.bioactmat.2026.03.062

Figure Lengend Snippet: Establishment of DUB-loaded bone-targeted liposomal delivery system. ( A ) Representative images and quantitative analysis of mineralized nodule formation via Alizarin Red S (ARS) staining in primary BMSCs for the effect of DUB@Lip on osteogenesis differentiation under conditions of 10 μM Dex. ( B ) RT-qPCR for the expression of osteogenesis-related genes in primary BMSCs of different groups. ( C-D ) In vitro cellular uptake assay of IR-780-labeled DUB@Lip liposomes in primary BMSCs by confocal microscopy and flow cytometry. ( E-F ) Evaluation of bone-targeting capacity and pharmacokinetic analysis of DUB@Lip and DUB@TLip via ex vivo fluorescence imaging. ( G-H ) Representative reconstructed images and quantification for Tb.BV/TV, Tb.N, Tb.Th, Tb.Sp, and Ct.Th in femora in mice of different groups by Micro-CT. ( I ) H&E staining and quantification for trabecular bone area in distal femora in mice of different groups. ( J ) Masson staining and quantification for collagen deposition fraction (collagen area/trabecular bone area) in distal femora in mice of different groups. n = 4 independent repeats by using different biological samples in each group for in vitro experiments, or 8 mice per group for in vivo assays. Data were means ± s.e.m. ns p > 0.05, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001 by one-way ANOVA. Scale bars: 200 μm (A-B), 2 mm (G left & right bottom), 1 mm (G right top), and 100 μm (I-J).

Article Snippet: To prepare non-targeted DUB-loaded liposomes, DSPE-PEG2000-ALN was substituted with an equimolar amount of DSPE-mPEG2000 (HY-142978, MedChemExpress, Shanghai, China) using the same preparation procedure.

Techniques: Staining, Quantitative RT-PCR, Expressing, In Vitro, Labeling, Liposomes, Confocal Microscopy, Flow Cytometry, Ex Vivo, Fluorescence, Imaging, Micro-CT, In Vivo