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limki3  (Tocris)


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    Tocris limki3
    Effects of <t>LIMKi3</t> (1 μM) on agonist‐ and EFS‐induced contractions of renal, interlobar arteries. Contractions were induced by noradrenaline (a), phenylephrine (b) or EFS (c), 30 min after addition of solvent (DMSO) to controls or LIMKi3 (1 μM). Data are obtained from n = 5 independent experiments per panel, performed with arteries from n = 5 animals, with each single experiment including a control and LIMKi3 group with tissues from the same animal, resulting in paired samples. Shown are means ± SD from all experiments in concentration and frequency response curves together with p values from two‐way ANOVA for whole groups, and all single E max , EC 50 , and EF 50 values from all experiments (calculated by curve fitting). p values ≥ 0.05 are not shown. E max and EC 50 values marked in gray represent the maximum tension in the concentration response curves, or the highest applied endothelin‐1 concentration, as curve fitting was not possible in this experiment.
    Limki3, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/limki3/product/Tocris
    Average 92 stars, based on 29 article reviews
    limki3 - by Bioz Stars, 2026-06
    92/100 stars

    Images

    1) Product Images from "Vasoactivity of Rac GTPase , Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction"

    Article Title: Vasoactivity of Rac GTPase , Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

    Journal: Pharmacology Research & Perspectives

    doi: 10.1002/prp2.70190

    Effects of LIMKi3 (1 μM) on agonist‐ and EFS‐induced contractions of renal, interlobar arteries. Contractions were induced by noradrenaline (a), phenylephrine (b) or EFS (c), 30 min after addition of solvent (DMSO) to controls or LIMKi3 (1 μM). Data are obtained from n = 5 independent experiments per panel, performed with arteries from n = 5 animals, with each single experiment including a control and LIMKi3 group with tissues from the same animal, resulting in paired samples. Shown are means ± SD from all experiments in concentration and frequency response curves together with p values from two‐way ANOVA for whole groups, and all single E max , EC 50 , and EF 50 values from all experiments (calculated by curve fitting). p values ≥ 0.05 are not shown. E max and EC 50 values marked in gray represent the maximum tension in the concentration response curves, or the highest applied endothelin‐1 concentration, as curve fitting was not possible in this experiment.
    Figure Legend Snippet: Effects of LIMKi3 (1 μM) on agonist‐ and EFS‐induced contractions of renal, interlobar arteries. Contractions were induced by noradrenaline (a), phenylephrine (b) or EFS (c), 30 min after addition of solvent (DMSO) to controls or LIMKi3 (1 μM). Data are obtained from n = 5 independent experiments per panel, performed with arteries from n = 5 animals, with each single experiment including a control and LIMKi3 group with tissues from the same animal, resulting in paired samples. Shown are means ± SD from all experiments in concentration and frequency response curves together with p values from two‐way ANOVA for whole groups, and all single E max , EC 50 , and EF 50 values from all experiments (calculated by curve fitting). p values ≥ 0.05 are not shown. E max and EC 50 values marked in gray represent the maximum tension in the concentration response curves, or the highest applied endothelin‐1 concentration, as curve fitting was not possible in this experiment.

    Techniques Used: Solvent, Control, Concentration Assay



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    Image Search Results


    Effects of LIMKi3 (1 μM) on agonist‐ and EFS‐induced contractions of renal, interlobar arteries. Contractions were induced by noradrenaline (a), phenylephrine (b) or EFS (c), 30 min after addition of solvent (DMSO) to controls or LIMKi3 (1 μM). Data are obtained from n = 5 independent experiments per panel, performed with arteries from n = 5 animals, with each single experiment including a control and LIMKi3 group with tissues from the same animal, resulting in paired samples. Shown are means ± SD from all experiments in concentration and frequency response curves together with p values from two‐way ANOVA for whole groups, and all single E max , EC 50 , and EF 50 values from all experiments (calculated by curve fitting). p values ≥ 0.05 are not shown. E max and EC 50 values marked in gray represent the maximum tension in the concentration response curves, or the highest applied endothelin‐1 concentration, as curve fitting was not possible in this experiment.

    Journal: Pharmacology Research & Perspectives

    Article Title: Vasoactivity of Rac GTPase , Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

    doi: 10.1002/prp2.70190

    Figure Lengend Snippet: Effects of LIMKi3 (1 μM) on agonist‐ and EFS‐induced contractions of renal, interlobar arteries. Contractions were induced by noradrenaline (a), phenylephrine (b) or EFS (c), 30 min after addition of solvent (DMSO) to controls or LIMKi3 (1 μM). Data are obtained from n = 5 independent experiments per panel, performed with arteries from n = 5 animals, with each single experiment including a control and LIMKi3 group with tissues from the same animal, resulting in paired samples. Shown are means ± SD from all experiments in concentration and frequency response curves together with p values from two‐way ANOVA for whole groups, and all single E max , EC 50 , and EF 50 values from all experiments (calculated by curve fitting). p values ≥ 0.05 are not shown. E max and EC 50 values marked in gray represent the maximum tension in the concentration response curves, or the highest applied endothelin‐1 concentration, as curve fitting was not possible in this experiment.

    Article Snippet: EHT1864, NSC23766, SR7826, LIMKi3, CMPD101, FRAX486, and SecinH3 were obtained from Tocris (Bristol, UK).

    Techniques: Solvent, Control, Concentration Assay