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ldn193189 inhibitor  (MedChemExpress)


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    MedChemExpress ldn193189 inhibitor
    Ldn193189 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 81 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ldn193189 inhibitor/product/MedChemExpress
    Average 95 stars, based on 81 article reviews
    ldn193189 inhibitor - by Bioz Stars, 2026-02
    95/100 stars

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    ( A ) Western blot analysis of phosphorylated Smad1/5/9 and total Smad1 in Th17 cells. ( C , D ) qRT-PCR quantification of Il17a and Rorc mRNA. ( E , F ) Flow cytometry analysis was conducted to assess the expression of IL-17a in CD4 + T cells. ( G ) ELISA measurement of IL-17 A in culture supernatants. (H) Western blot detection of phosphorylated Stat3 and total Stat3 in Th17 cells. ( I ) Cross-linking of Smad1 and Stat3 in Th17 was detected by co-immunoprecipitation experiment (IgG immunoprecipitation as negative control). ( J ) Nuclear Stat3 protein levels were assessed by Western blotting. Quantitative analysis of Stat3/H3 ratio. Data are normalized to the group without BMP6 and <t>LDN193189</t> (set as 1.0). Statistical significance was determined by one-way ANOVA followed by a Bonferroni post hoc test. Data are reported as means ± SD ( n = 3). * P ≤ 0.05; ** P ≤ 0.01; *** P ≤ 0.001, ns = not significant. IL-17, interleukin-17; BMP, bone morphogenetic protein.
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    ( A ) Western blot analysis of phosphorylated Smad1/5/9 and total Smad1 in Th17 cells. ( C , D ) qRT-PCR quantification of Il17a and Rorc mRNA. ( E , F ) Flow cytometry analysis was conducted to assess the expression of IL-17a in CD4 + T cells. ( G ) ELISA measurement of IL-17 A in culture supernatants. (H) Western blot detection of phosphorylated Stat3 and total Stat3 in Th17 cells. ( I ) Cross-linking of Smad1 and Stat3 in Th17 was detected by co-immunoprecipitation experiment (IgG immunoprecipitation as negative control). ( J ) Nuclear Stat3 protein levels were assessed by Western blotting. Quantitative analysis of Stat3/H3 ratio. Data are normalized to the group without BMP6 and <t>LDN193189</t> (set as 1.0). Statistical significance was determined by one-way ANOVA followed by a Bonferroni post hoc test. Data are reported as means ± SD ( n = 3). * P ≤ 0.05; ** P ≤ 0.01; *** P ≤ 0.001, ns = not significant. IL-17, interleukin-17; BMP, bone morphogenetic protein.
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    ( A ) Western blot analysis of phosphorylated Smad1/5/9 and total Smad1 in Th17 cells. ( C , D ) qRT-PCR quantification of Il17a and Rorc mRNA. ( E , F ) Flow cytometry analysis was conducted to assess the expression of IL-17a in CD4 + T cells. ( G ) ELISA measurement of IL-17 A in culture supernatants. (H) Western blot detection of phosphorylated Stat3 and total Stat3 in Th17 cells. ( I ) Cross-linking of Smad1 and Stat3 in Th17 was detected by co-immunoprecipitation experiment (IgG immunoprecipitation as negative control). ( J ) Nuclear Stat3 protein levels were assessed by Western blotting. Quantitative analysis of Stat3/H3 ratio. Data are normalized to the group without BMP6 and LDN193189 (set as 1.0). Statistical significance was determined by one-way ANOVA followed by a Bonferroni post hoc test. Data are reported as means ± SD ( n = 3). * P ≤ 0.05; ** P ≤ 0.01; *** P ≤ 0.001, ns = not significant. IL-17, interleukin-17; BMP, bone morphogenetic protein.

    Journal: Inflammation

    Article Title: Bone Morphogenetic Protein 6 Attenuates Psoriasis Pathogenesis by Suppressing Th17 Cell Differentiation

    doi: 10.1007/s10753-025-02412-3

    Figure Lengend Snippet: ( A ) Western blot analysis of phosphorylated Smad1/5/9 and total Smad1 in Th17 cells. ( C , D ) qRT-PCR quantification of Il17a and Rorc mRNA. ( E , F ) Flow cytometry analysis was conducted to assess the expression of IL-17a in CD4 + T cells. ( G ) ELISA measurement of IL-17 A in culture supernatants. (H) Western blot detection of phosphorylated Stat3 and total Stat3 in Th17 cells. ( I ) Cross-linking of Smad1 and Stat3 in Th17 was detected by co-immunoprecipitation experiment (IgG immunoprecipitation as negative control). ( J ) Nuclear Stat3 protein levels were assessed by Western blotting. Quantitative analysis of Stat3/H3 ratio. Data are normalized to the group without BMP6 and LDN193189 (set as 1.0). Statistical significance was determined by one-way ANOVA followed by a Bonferroni post hoc test. Data are reported as means ± SD ( n = 3). * P ≤ 0.05; ** P ≤ 0.01; *** P ≤ 0.001, ns = not significant. IL-17, interleukin-17; BMP, bone morphogenetic protein.

    Article Snippet: LDN193189 (HY-12071) was sourced from MedChemExpress (Shanghai, China).

    Techniques: Western Blot, Quantitative RT-PCR, Flow Cytometry, Expressing, Enzyme-linked Immunosorbent Assay, Immunoprecipitation, Negative Control