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FUJIFILM las-4000 luminescent image analyzer
Las 4000 Luminescent Image Analyzer, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/las-4000/las+3000/pmc10086475__jmg___2022___108690supp005-54-5-9
Average 90 stars, based on 1 article reviews
las-4000 luminescent image analyzer - by Bioz Stars, 2026-10
90/100 stars

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Related Articles

Western Blot:

Article Title: Mitochondrial fumarate inhibits Parkin-mediated mitophagy.
Article Snippet: Article Mitochondrial fumarate inhibits Parkin-mediated mitophagy Graphical abstract Highlights • Fumarate succinates Parkin at cysteine residues 323 and 451 • Parkin succination inhibits its E3 ligase activity and mitochondrial translocation • Parkin succination suppresses PINK1-Parkin-mediated mitophagy • Parkin succination links aging, impaired mitophagy, and neurodegeneration Authors Su Jin Ham, Sunhoe Bang, Daihn Woo, ..., Daehyun Baek, Jong-Seo Kim, Jongkyeong Chung Correspondence jongseokim@snu.ac.kr (J.-S.K.), jkc@snu.ac.kr (J.C.) In brief Ham et al. identify fumarate as an endogenous inhibitor of PINK1-Parkin- mediated mitophagy through succination of specific cysteine residues in Parkin.. This metabolite-induced modification disrupts Parkin’s function and induces Parkinson’s-disease-related phenotypes in fruit flies, highlighting a mechanistic connection between aging, metabolism, and neurodegeneration.. Ham et al., 2025, Molecular Cell 85, 1–16 June 19, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.molcel.2025.05.021 ll

Article Title: Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia.
Article Snippet: The next day, the membranes were incubated with horseradish peroxidase-conjugated secondary rabbit or mouse antibody (Bio-RAD, Cat#170–6515, Cat#170-6516) at RT for 1 h. After adding ECL substrates (Bio-RAD, Cat#170– 5061), the blots were then visualized on LAS-4000 (FUJIFILM) or Vilber Chemiluminescence system (Vilber).

Article Title: Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury.
Article Snippet: Title page; 1 Characterization of FAM114A1: A Novel Podocyte Cytoskeleton-Associated Protein Upregulated in 2 Glomerular Injury 3 4 Authors 5 Norifumi Hayashi 1, , 6 Sudhir Kumar , 7 Claire Trivin-Avillach , 8 Xueping Fan , 9 Shana V Stoddard , 10 Ryoko Akai , 11 Keiji Fujimoto , 12 Takao Iwawaki , 13 Hitoshi Yokoyama , 14 Kengo Furuichi , 15 Laurence H. Beck, Jr . 16 17 1.. Department of Medicine, Boston Medical Center and Department of Medicine, Boston University.. 18 Chobanian & Avedisian School of Medicine.

Article Title: Reciprocal rescue of Wolfram syndrome by two causative genes.
Article Snippet: LAS-4000 (Fujifilm) was used to develop and observe the dot blots.

Article Title: A refined method for high-purity isolation of uterine glandular epithelial cells in mouse.
Article Snippet: The uterine endometrium consists of luminal epithelium, glandular epithelium, and stromal cells, with uterine glands playing a pivotal role in pregnancy success among mammals.. Uterine glands secrete essential factors that regulate embryo development and implantation; however, their cellular biology remains poorly understood.. This study presents a refined method for isolating three distinct endometrial cell types with high purity, with a specific emphasis on glandular epithelial cells.

Article Title: Nicotine increases hepatocyte transthyretin turnover: A possible mechanism for the protective effect of smoking on preeclampsia?
Article Snippet: Transthyretin is a thyroid hormone binding protein with a major role in the distribution of thyroid hormones to peripheral tissues.. In preeclampsia, the failing placenta releases soluble endoglin into the maternal circulation causing systemic vascular dysfunction.. Our group has previously shown that transthyretin binds to soluble endoglin and is taken up as a complex into hepatocytes.

Article Title: A chimeric antigen receptor tailored to integrate complementary activation signals potentiates the antitumor activity of NK cells.
Article Snippet: Blots were developed using SuperSignal West Pico (Thermo) and detected using LAS-4000 (Fujifilm).

Article Title: Digoxin promotes anoikis of circulating cancer cells by targeting Na + /K + -ATPase α3-isoform.
Article Snippet: Signals were visualized using LAS-4000 (FujiFilm).

Incubation:

Article Title: Mitochondrial fumarate inhibits Parkin-mediated mitophagy.
Article Snippet: Article Mitochondrial fumarate inhibits Parkin-mediated mitophagy Graphical abstract Highlights • Fumarate succinates Parkin at cysteine residues 323 and 451 • Parkin succination inhibits its E3 ligase activity and mitochondrial translocation • Parkin succination suppresses PINK1-Parkin-mediated mitophagy • Parkin succination links aging, impaired mitophagy, and neurodegeneration Authors Su Jin Ham, Sunhoe Bang, Daihn Woo, ..., Daehyun Baek, Jong-Seo Kim, Jongkyeong Chung Correspondence jongseokim@snu.ac.kr (J.-S.K.), jkc@snu.ac.kr (J.C.) In brief Ham et al. identify fumarate as an endogenous inhibitor of PINK1-Parkin- mediated mitophagy through succination of specific cysteine residues in Parkin.. This metabolite-induced modification disrupts Parkin’s function and induces Parkinson’s-disease-related phenotypes in fruit flies, highlighting a mechanistic connection between aging, metabolism, and neurodegeneration.. Ham et al., 2025, Molecular Cell 85, 1–16 June 19, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.molcel.2025.05.021 ll

Article Title: Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia.
Article Snippet: The next day, the membranes were incubated with horseradish peroxidase-conjugated secondary rabbit or mouse antibody (Bio-RAD, Cat#170–6515, Cat#170-6516) at RT for 1 h. After adding ECL substrates (Bio-RAD, Cat#170– 5061), the blots were then visualized on LAS-4000 (FUJIFILM) or Vilber Chemiluminescence system (Vilber).

Article Title: Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury.
Article Snippet: Title page; 1 Characterization of FAM114A1: A Novel Podocyte Cytoskeleton-Associated Protein Upregulated in 2 Glomerular Injury 3 4 Authors 5 Norifumi Hayashi 1, , 6 Sudhir Kumar , 7 Claire Trivin-Avillach , 8 Xueping Fan , 9 Shana V Stoddard , 10 Ryoko Akai , 11 Keiji Fujimoto , 12 Takao Iwawaki , 13 Hitoshi Yokoyama , 14 Kengo Furuichi , 15 Laurence H. Beck, Jr . 16 17 1.. Department of Medicine, Boston Medical Center and Department of Medicine, Boston University.. 18 Chobanian & Avedisian School of Medicine.

Article Title: Reciprocal rescue of Wolfram syndrome by two causative genes.
Article Snippet: LAS-4000 (Fujifilm) was used to develop and observe the dot blots.

Article Title: A refined method for high-purity isolation of uterine glandular epithelial cells in mouse.
Article Snippet: The uterine endometrium consists of luminal epithelium, glandular epithelium, and stromal cells, with uterine glands playing a pivotal role in pregnancy success among mammals.. Uterine glands secrete essential factors that regulate embryo development and implantation; however, their cellular biology remains poorly understood.. This study presents a refined method for isolating three distinct endometrial cell types with high purity, with a specific emphasis on glandular epithelial cells.

Article Title: Nicotine increases hepatocyte transthyretin turnover: A possible mechanism for the protective effect of smoking on preeclampsia?
Article Snippet: Transthyretin is a thyroid hormone binding protein with a major role in the distribution of thyroid hormones to peripheral tissues.. In preeclampsia, the failing placenta releases soluble endoglin into the maternal circulation causing systemic vascular dysfunction.. Our group has previously shown that transthyretin binds to soluble endoglin and is taken up as a complex into hepatocytes.

Article Title: A chimeric antigen receptor tailored to integrate complementary activation signals potentiates the antitumor activity of NK cells.
Article Snippet: Blots were developed using SuperSignal West Pico (Thermo) and detected using LAS-4000 (Fujifilm).

Article Title: Digoxin promotes anoikis of circulating cancer cells by targeting Na + /K + -ATPase α3-isoform.
Article Snippet: Signals were visualized using LAS-4000 (FujiFilm).

Immunoprecipitation:

Article Title: Mitochondrial fumarate inhibits Parkin-mediated mitophagy.
Article Snippet: Article Mitochondrial fumarate inhibits Parkin-mediated mitophagy Graphical abstract Highlights • Fumarate succinates Parkin at cysteine residues 323 and 451 • Parkin succination inhibits its E3 ligase activity and mitochondrial translocation • Parkin succination suppresses PINK1-Parkin-mediated mitophagy • Parkin succination links aging, impaired mitophagy, and neurodegeneration Authors Su Jin Ham, Sunhoe Bang, Daihn Woo, ..., Daehyun Baek, Jong-Seo Kim, Jongkyeong Chung Correspondence jongseokim@snu.ac.kr (J.-S.K.), jkc@snu.ac.kr (J.C.) In brief Ham et al. identify fumarate as an endogenous inhibitor of PINK1-Parkin- mediated mitophagy through succination of specific cysteine residues in Parkin.. This metabolite-induced modification disrupts Parkin’s function and induces Parkinson’s-disease-related phenotypes in fruit flies, highlighting a mechanistic connection between aging, metabolism, and neurodegeneration.. Ham et al., 2025, Molecular Cell 85, 1–16 June 19, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.molcel.2025.05.021 ll

Article Title: Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia.
Article Snippet: The next day, the membranes were incubated with horseradish peroxidase-conjugated secondary rabbit or mouse antibody (Bio-RAD, Cat#170–6515, Cat#170-6516) at RT for 1 h. After adding ECL substrates (Bio-RAD, Cat#170– 5061), the blots were then visualized on LAS-4000 (FUJIFILM) or Vilber Chemiluminescence system (Vilber).

Article Title: Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury.
Article Snippet: Title page; 1 Characterization of FAM114A1: A Novel Podocyte Cytoskeleton-Associated Protein Upregulated in 2 Glomerular Injury 3 4 Authors 5 Norifumi Hayashi 1, , 6 Sudhir Kumar , 7 Claire Trivin-Avillach , 8 Xueping Fan , 9 Shana V Stoddard , 10 Ryoko Akai , 11 Keiji Fujimoto , 12 Takao Iwawaki , 13 Hitoshi Yokoyama , 14 Kengo Furuichi , 15 Laurence H. Beck, Jr . 16 17 1.. Department of Medicine, Boston Medical Center and Department of Medicine, Boston University.. 18 Chobanian & Avedisian School of Medicine.

Article Title: Reciprocal rescue of Wolfram syndrome by two causative genes.
Article Snippet: LAS-4000 (Fujifilm) was used to develop and observe the dot blots.

Article Title: A refined method for high-purity isolation of uterine glandular epithelial cells in mouse.
Article Snippet: The uterine endometrium consists of luminal epithelium, glandular epithelium, and stromal cells, with uterine glands playing a pivotal role in pregnancy success among mammals.. Uterine glands secrete essential factors that regulate embryo development and implantation; however, their cellular biology remains poorly understood.. This study presents a refined method for isolating three distinct endometrial cell types with high purity, with a specific emphasis on glandular epithelial cells.

Article Title: Nicotine increases hepatocyte transthyretin turnover: A possible mechanism for the protective effect of smoking on preeclampsia?
Article Snippet: Transthyretin is a thyroid hormone binding protein with a major role in the distribution of thyroid hormones to peripheral tissues.. In preeclampsia, the failing placenta releases soluble endoglin into the maternal circulation causing systemic vascular dysfunction.. Our group has previously shown that transthyretin binds to soluble endoglin and is taken up as a complex into hepatocytes.

Article Title: A chimeric antigen receptor tailored to integrate complementary activation signals potentiates the antitumor activity of NK cells.
Article Snippet: Blots were developed using SuperSignal West Pico (Thermo) and detected using LAS-4000 (Fujifilm).

Article Title: Digoxin promotes anoikis of circulating cancer cells by targeting Na + /K + -ATPase α3-isoform.
Article Snippet: Signals were visualized using LAS-4000 (FujiFilm).



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