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kt182  (MedChemExpress)


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    Structured Review

    MedChemExpress kt182
    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, <t>KT182,</t> and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.
    Kt182, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kt182/product/MedChemExpress
    Average 92 stars, based on 3 article reviews
    kt182 - by Bioz Stars, 2026-02
    92/100 stars

    Images

    1) Product Images from "Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling"

    Article Title: Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2022.941522

    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, KT182, and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.
    Figure Legend Snippet: Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, KT182, and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.

    Techniques Used: Western Blot, Expressing, Labeling, Concentration Assay



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    kt182  (MedChemExpress)
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    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, <t>KT182,</t> and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.
    Kt182, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    kt182, an inhibitor of abhd6  (Cayman Chemical)
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    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, <t>KT182,</t> and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.
    Kt182, An Inhibitor Of Abhd6, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    kt182  (Millipore)
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    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, <t>KT182,</t> and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.
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    Millipore abhd6 inhibitor 4-[39-(hydroxymethyl)(1,19-biphenyl)-4-yl]-[1h]-1,2,3-triazol1-yl(2-phenyl-1-piperidinyl)-methanone (kt182)
    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, <t>KT182,</t> and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.
    Abhd6 Inhibitor 4 [39 (Hydroxymethyl)(1,19 Biphenyl) 4 Yl] [1h] 1,2,3 Triazol1 Yl(2 Phenyl 1 Piperidinyl) Methanone (Kt182), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, KT182, and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.

    Journal: Frontiers in Pharmacology

    Article Title: Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling

    doi: 10.3389/fphar.2022.941522

    Figure Lengend Snippet: Screening several cancers cells lines to identify the potential target(s) of compounds with antiproliferative activities using competitive ABPP. (A) Western blot analysis of the expression of endogenous MAGL, ABHD6, and ABHD12 in the cancer cell lines. (B) Comparative ABPP analysis of the potential targets labeled by serine hydrolase probe FP-TAMRA. (C–J) Competitive ABPP gel results of compounds 1 , 9 , 17 , 23 , 24 , 64 , 82 , 93 , 95 , 98 , 101 , 102 , 104 , 127, and 154 show the selectivity profile across serine hydrolases labeled by FP-TAMRA (500 nM). Note that the concentration of KML29, KT182, and DO264 was 10 μM, respectively. (K) Heatmap overview of the number of potential targets (identified by the quantification of protein bands in ABPP) for compounds with antiproliferative activities in various cancer cells.

    Article Snippet: DO264 and KT182 were from MedChemExpress with ≥98% purity.

    Techniques: Western Blot, Expressing, Labeling, Concentration Assay