Review



kg501  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 95
      Buy from Supplier

    Structured Review

    MedChemExpress kg501
    Kg501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kg501/KG-501/pm41690429-87-29-30
    Average 95 stars, based on 32 article reviews
    kg501 - by Bioz Stars, 2026-09
    95/100 stars

    Images

    Related Articles

    Incubation:

    Article Title: Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats
    Article Snippet: The cells were placed in Dulbecco’s modified Eagle’s medium containing 10% fetal bovine serum, 100 μ/mL penicillin and 100 ng/mL streptomycin (HY-B0472, MCE) and maintained at 37°C under 5% CO 2. .. The cells were seeded in 6-well plates and incubated with different drugs treatment: 100 μM perampanel [ ], 100 μM SQ22536 (HY-100396, MedChemExpress), a adenylate cyclase (AC) inhibitor; 10 μM forskolin (HY-15371, MedChemExpress), a AC agonist; 10 μM H-89 (HY-15979, MedChemExpress), a protein kinase A (PKA) inhibitor; 0.1 mM 8-bromo-cAMP sodium salt (HY-12306, MedChemExpress), a PKA agonist and 25 μM KG501 (HY-103299, MedChemExpress), and a cAMP-responsive-element-binding protein (CREB) inhibitor for 24 hours. ..

    Article Title: Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats.
    Article Snippet: The cells were placed in Dulbecco’s modified Eagle’s medium containing 10% fetal bovine serum, 100 μ/mL penicillin and 100 ng/mL streptomycin (HY-B0472, MCE) and maintained at 37°C under 5% CO2. .. The cells were seeded in 6-well plates and incubated with different drugs treatment: 100 μM perampanel [21], 100 μM SQ22536 (HY100396, MedChemExpress), a adenylate cyclase (AC) inhibitor; 10 μM forskolin (HY-15371, MedChemExpress), a AC agonist; 10 μM H-89 (HY-15979, MedChemExpress), a protein kinase A (PKA) inhibitor; 0.1 mM 8-bromo-cAMP sodium salt (HY-12306, MedChemExpress), a PKA agonist and 25 μM KG501 (HY-103299, MedChemExpress), and a cAMP-responsive-element-binding protein (CREB) inhibitor for 24 hours. ..

    Modification:

    Article Title: Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
    Article Snippet: Icariin (ICA), extracted from Epimedium, is a flavonoid used in traditional Chinese medicine.. Di(2-ethylhexyl) phthalate (DEHP) is a phthalate used in commercial products as a plasticizer that can influence the human endocrine and reproduction system.. We previously found that ICA reversed DEHP-induced damage through the prevention of reactive oxygen species accumulation and promotion of testosterone secretion.

    CMC:

    Article Title: Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
    Article Snippet: Icariin (ICA), extracted from Epimedium, is a flavonoid used in traditional Chinese medicine.. Di(2-ethylhexyl) phthalate (DEHP) is a phthalate used in commercial products as a plasticizer that can influence the human endocrine and reproduction system.. We previously found that ICA reversed DEHP-induced damage through the prevention of reactive oxygen species accumulation and promotion of testosterone secretion.

    CCK-8 Assay:

    Article Title: Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
    Article Snippet: Icariin (ICA), extracted from Epimedium, is a flavonoid used in traditional Chinese medicine.. Di(2-ethylhexyl) phthalate (DEHP) is a phthalate used in commercial products as a plasticizer that can influence the human endocrine and reproduction system.. We previously found that ICA reversed DEHP-induced damage through the prevention of reactive oxygen species accumulation and promotion of testosterone secretion.



    Similar Products

    kg501  (MedChemExpress)
    95
    MedChemExpress kg501
    Kg501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kg501/KG-501/pm41690429-87-29-30
    Average 95 stars, based on 1 article reviews
    kg501 - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier
    creb inhibitor kg501  (MedChemExpress)
    95
    MedChemExpress creb inhibitor kg501
    Creb Inhibitor Kg501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kg501/KG-501/pm41276512-600-8-13
    Average 95 stars, based on 1 article reviews
    creb inhibitor kg501 - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier
    kg501  (Selleck Chemicals)
    93
    Selleck Chemicals kg501
    Kg501, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kg501/KG-501/pmc12130531__12276_2025_1447_MOESM1_ESM-111-9-10
    Average 93 stars, based on 1 article reviews
    kg501 - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier
    creb inhibitor 24 kg501  (MedChemExpress)
    95
    MedChemExpress creb inhibitor 24 kg501
    Creb Inhibitor 24 Kg501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kg501/KG-501/pmc11775255__41398_2025_3257_MOESM1_ESM-7-1-13
    Average 95 stars, based on 1 article reviews
    creb inhibitor 24 kg501 - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier
    kg501 ([3-[(4-chlorophenyl) carbamoyl]-naphthalen-2-yl] dihydrogen phosphate  (Millipore)
    90
    Millipore kg501 ([3-[(4-chlorophenyl) carbamoyl]-naphthalen-2-yl] dihydrogen phosphate
    The effect of <t>KG501</t> (a specific inhibitor p-CREB) on proliferation and apoptosis levels in OGD NSCs. (A) CART55-102(0.8 nM) treatment protects against loss of the structure of NSCs (Nestin, red) and enhances Nestin (Red) expression and KG501 inhibits the protection of structure in cultured oxygen and glucose deprived NSCs. Scale bar = 100 pm. (B) CART55-102(0.8 nM) treatment enhances Sox-2(Green) expression and KG501 inhibits the protection of neural stem cells in cultured oxygen and glucose deprived. Scale bar = 50 μm (C) CART55-102(0.8 nM) treatment increases the proliferation of oxygen and glucose deprived neural stem cells and KG-501 inhibits the proliferation of NSCs in cultured oxygen and glucose deprived. Scale bar = 100um. (D) Quantitative analysis of fluorescence results using ImageJ software. Data was presented as mean ± SEM, *** p < 0.001, ### p < 0.001. (E) The protein levels Bcl-2 and Bax were measured by Western blot in different groups. (F) Quantitative analysis of Bcl-2 expression. Blot images were cropped for comparison. All values are expressed as mean ± SEM of the band intensity of Bcl-2 normalized to Tubulin from 3 independent experiments. Compared with the OGD, after treatment CART55-102 (0.8 nM), the levels of Bcl-2 significantly increased. But the levels of Bcl-2 were significantly decreased after pre-treatment with KG501 in the CART treatment group. ** p < 0.001, *** p < 0.01, ## p < 0.01, ### p < 0.001. (G) Quantitative analysis of Bax expression. Blot images were cropped for comparison. All values are expressed as meant ± SEM of the band intensity of Bax normalized to Tubulin from 3 independent experiments. Compare with OGD, after treatment CART55-102(0.8 nM), the levels of Bax significantly decreased. But the levels of Bax were significantly increased after pre-treatment with KG501 in the CART treatment group. *** p < 0.001, ### p < 0.001. (H) The protein levels of p-CREB were measured by Western blot in different groups. (I) Quantitative analysis p-CREB expression. Blot images were cropped for comparation. All values are expressed as mean ± SEM of the band intensity of p-CREB normalized to 3 independent experiments. Compare with the OGD, after treatment CART55-102(0.8 nM), the levels of p-CREB significantly increased. But the levels of p-CREB were significantly decreased after pre-treatment with KG501 in the CART treatment group. *** p < 0.001, ## p < 0.01.
    Kg501 ([3 [(4 Chlorophenyl) Carbamoyl] Naphthalen 2 Yl] Dihydrogen Phosphate, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kg501/kg+501/pmc11368759-59-0-7
    Average 90 stars, based on 1 article reviews
    kg501 ([3-[(4-chlorophenyl) carbamoyl]-naphthalen-2-yl] dihydrogen phosphate - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    The effect of KG501 (a specific inhibitor p-CREB) on proliferation and apoptosis levels in OGD NSCs. (A) CART55-102(0.8 nM) treatment protects against loss of the structure of NSCs (Nestin, red) and enhances Nestin (Red) expression and KG501 inhibits the protection of structure in cultured oxygen and glucose deprived NSCs. Scale bar = 100 pm. (B) CART55-102(0.8 nM) treatment enhances Sox-2(Green) expression and KG501 inhibits the protection of neural stem cells in cultured oxygen and glucose deprived. Scale bar = 50 μm (C) CART55-102(0.8 nM) treatment increases the proliferation of oxygen and glucose deprived neural stem cells and KG-501 inhibits the proliferation of NSCs in cultured oxygen and glucose deprived. Scale bar = 100um. (D) Quantitative analysis of fluorescence results using ImageJ software. Data was presented as mean ± SEM, *** p < 0.001, ### p < 0.001. (E) The protein levels Bcl-2 and Bax were measured by Western blot in different groups. (F) Quantitative analysis of Bcl-2 expression. Blot images were cropped for comparison. All values are expressed as mean ± SEM of the band intensity of Bcl-2 normalized to Tubulin from 3 independent experiments. Compared with the OGD, after treatment CART55-102 (0.8 nM), the levels of Bcl-2 significantly increased. But the levels of Bcl-2 were significantly decreased after pre-treatment with KG501 in the CART treatment group. ** p < 0.001, *** p < 0.01, ## p < 0.01, ### p < 0.001. (G) Quantitative analysis of Bax expression. Blot images were cropped for comparison. All values are expressed as meant ± SEM of the band intensity of Bax normalized to Tubulin from 3 independent experiments. Compare with OGD, after treatment CART55-102(0.8 nM), the levels of Bax significantly decreased. But the levels of Bax were significantly increased after pre-treatment with KG501 in the CART treatment group. *** p < 0.001, ### p < 0.001. (H) The protein levels of p-CREB were measured by Western blot in different groups. (I) Quantitative analysis p-CREB expression. Blot images were cropped for comparation. All values are expressed as mean ± SEM of the band intensity of p-CREB normalized to 3 independent experiments. Compare with the OGD, after treatment CART55-102(0.8 nM), the levels of p-CREB significantly increased. But the levels of p-CREB were significantly decreased after pre-treatment with KG501 in the CART treatment group. *** p < 0.001, ## p < 0.01.

    Journal: Frontiers in Neuroscience

    Article Title: Cocaine amphetamine-regulated transcription peptide inhibits apoptosis in oxygen–glucose deprived neural stem cells

    doi: 10.3389/fnins.2024.1424719

    Figure Lengend Snippet: The effect of KG501 (a specific inhibitor p-CREB) on proliferation and apoptosis levels in OGD NSCs. (A) CART55-102(0.8 nM) treatment protects against loss of the structure of NSCs (Nestin, red) and enhances Nestin (Red) expression and KG501 inhibits the protection of structure in cultured oxygen and glucose deprived NSCs. Scale bar = 100 pm. (B) CART55-102(0.8 nM) treatment enhances Sox-2(Green) expression and KG501 inhibits the protection of neural stem cells in cultured oxygen and glucose deprived. Scale bar = 50 μm (C) CART55-102(0.8 nM) treatment increases the proliferation of oxygen and glucose deprived neural stem cells and KG-501 inhibits the proliferation of NSCs in cultured oxygen and glucose deprived. Scale bar = 100um. (D) Quantitative analysis of fluorescence results using ImageJ software. Data was presented as mean ± SEM, *** p < 0.001, ### p < 0.001. (E) The protein levels Bcl-2 and Bax were measured by Western blot in different groups. (F) Quantitative analysis of Bcl-2 expression. Blot images were cropped for comparison. All values are expressed as mean ± SEM of the band intensity of Bcl-2 normalized to Tubulin from 3 independent experiments. Compared with the OGD, after treatment CART55-102 (0.8 nM), the levels of Bcl-2 significantly increased. But the levels of Bcl-2 were significantly decreased after pre-treatment with KG501 in the CART treatment group. ** p < 0.001, *** p < 0.01, ## p < 0.01, ### p < 0.001. (G) Quantitative analysis of Bax expression. Blot images were cropped for comparison. All values are expressed as meant ± SEM of the band intensity of Bax normalized to Tubulin from 3 independent experiments. Compare with OGD, after treatment CART55-102(0.8 nM), the levels of Bax significantly decreased. But the levels of Bax were significantly increased after pre-treatment with KG501 in the CART treatment group. *** p < 0.001, ### p < 0.001. (H) The protein levels of p-CREB were measured by Western blot in different groups. (I) Quantitative analysis p-CREB expression. Blot images were cropped for comparation. All values are expressed as mean ± SEM of the band intensity of p-CREB normalized to 3 independent experiments. Compare with the OGD, after treatment CART55-102(0.8 nM), the levels of p-CREB significantly increased. But the levels of p-CREB were significantly decreased after pre-treatment with KG501 in the CART treatment group. *** p < 0.001, ## p < 0.01.

    Article Snippet: KG501 ([3-[(4-chlorophenyl) carbamoyl]-naphthalen-2-yl] dihydrogen phosphate) was from Sigma-Aldrich (St. Louis, MO, United States).

    Techniques: Expressing, Cell Culture, Fluorescence, Software, Western Blot, Comparison