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human interleukin 12 rhil 12  (Neumedicines Inc)

 
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    Neumedicines Inc human interleukin 12 rhil 12
    Human Interleukin 12 Rhil 12, supplied by Neumedicines Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/interleukin+12/12+12+human+interleukin+rhil/us12655159-798-5-11
    Average 86 stars, based on 1 article reviews
    human interleukin 12 rhil 12 - by Bioz Stars, 2026-11
    86/100 stars

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    Article Title: CBL-B modulators and uses thereof
    Article Snippet: In some embodiments, an IL-15 based immunotherapeutic is heterodimeric IL-15 (hetIL-15, Novartis/Admune), a fusion complex composed of a synthetic form of endogenous IL-15 complexed to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL15:sIL-15RA), which has been tested in Phase 1 clinical trials for melanoma, renal cell carcinoma, non-small cell lung cancer and head and neck squamous cell carcinoma (NCT02452268).

    Article Title: Deuterated IRAK degraders and uses thereof
    Article Snippet: In some embodiments, an immunostimulatory therapeutic is recombinant human interleukin 15 (rhIL-15).

    Article Title: GPR84 antagonists and uses thereof
    Article Snippet: In some embodiments, a recombinant human interleukin 12 (rhIL-12) is NM-ILL-12 (Neumedicines, Inc.), NCT02544724, or NCT02542124.

    Article Title: Antiproliferation compounds and uses thereof
    Article Snippet: Another immunostimulatory therapeutic that may be used in the present invention is recombinant human interleukin 15 (rhIL-15).

    Article Title: SMARCA degraders and uses thereof
    Article Snippet: In some embodiments, a recombinant human interleukin 12 (rhIL-12) is NM-IL-12 (Neumedicines, Inc.), NCT02544724, or NCT02542124.

    Article Title: Alkaline phosphate-based oncology treatments
    Article Snippet: In some embodiments, the additional agent is an interleukin, such as IL-12 (e.g., HEMAMAX (NEUMEDICINES, INC.)).

    Recombinant:

    Article Title: Antiproliferation compounds and uses thereof
    Article Snippet: Another suitable IL-15 based immunotherapeutic is heterodimeric IL-15 (hetIL-15, Novartis/Admune), a fusion complex composed of a synthetic form of endogenous IL-15 complexed to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL15:sIL-15RA), which has been tested in Phase 1 clinical trials for melanoma, renal cell carcinoma, non-small cell lung cancer and head and neck squamous cell carcinoma (NCT02452268). .. Recombinant human interleukin 12 (rhIL-12) has been tested in the clinic for many oncological indications, for example, as a therapy for lymphoma (NM-IL-12, Neumedicines, Inc.), (NCT02544724 and NCT02542124). .. Another suitable IL-15 based immunotherapeutic is heterodimeric IL-15 (hetIL-15, Novartis/Admune), a fusion complex composed of a synthetic form of endogenous IL-15 complexed to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL15:sIL-15RA), which has been tested in Phase 1 clinical trials for melanoma, renal cell carcinoma, non-small cell lung cancer and head and neck squamous cell carcinoma (NCT02452268).

    Article Title: IRAK degraders and uses thereof
    Article Snippet: In some embodiments, an IL-15 based immunotherapeutic is heterodimeric IL-15 (hetIL-15, Novartis/Admune), a fusion complex composed of a synthetic form of endogenous IL-15 complexed to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL15:sIL-15RA), which has been tested in Phase 1 clinical trials for melanoma, renal cell carcinoma, non-small cell lung cancer and head and neck squamous cell carcinoma (NCT02452268). .. In some embodiments, a recombinant human interleukin 12 (rhlL-12) is NM-IL-12 (Neumedicines, Inc.), NCT02544724, or NCT02542124. ..



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    Image Search Results


    ( A ) Western blot detection of PD-1 protein expression; ( B ) In vitro bactericidal activity of Kupffer cells against K. pneumoniae evaluated by enumerating viable bacteria; ( C–E ) IL-6 ( C ), IL-12 ( D ), and TNF-α ( E ) levels measured by ELISA; (F-H) Flow-cytometric detection of IL-6( F ), IL-12( G ), and TNF-α(H) proportions; ( I ) Flow-cytometric analysis of Kupffer-cell phagocytic capacity; ( J ) Western blot detection of SHP2, p-SHP2, STAT1, p-STAT1, NF-κB p65, and p-NF-κB p65. * P < 0.05.

    Journal: Journal of Microbiology and Biotechnology

    Article Title: Anti-PD-1 Therapy Alleviates Klebsiella pneumoniae -Induced Liver Abscess by Effectively Activating Kupffer Cells

    doi: 10.4014/jmb.2602.02040

    Figure Lengend Snippet: ( A ) Western blot detection of PD-1 protein expression; ( B ) In vitro bactericidal activity of Kupffer cells against K. pneumoniae evaluated by enumerating viable bacteria; ( C–E ) IL-6 ( C ), IL-12 ( D ), and TNF-α ( E ) levels measured by ELISA; (F-H) Flow-cytometric detection of IL-6( F ), IL-12( G ), and TNF-α(H) proportions; ( I ) Flow-cytometric analysis of Kupffer-cell phagocytic capacity; ( J ) Western blot detection of SHP2, p-SHP2, STAT1, p-STAT1, NF-κB p65, and p-NF-κB p65. * P < 0.05.

    Article Snippet: The concentrations of TNF-α (E-EL-M3063, Elabscience, China), IL-6 (E-EL-M0044, Elabscience, China), and IL-12 (E-EL-M3062, Elabscience, China) in the supernatant were determined with ELISA kits.

    Techniques: Western Blot, Expressing, In Vitro, Activity Assay, Bacteria, Enzyme-linked Immunosorbent Assay, Analysis

    ( A ) In vitro bactericidal activity of Kupffer cells against K. pneumoniae evaluated by enumerating viable bacteria; ( B–D ) IL-6 ( B ), IL-12 ( C ), and TNF-α ( D ) levels measured by ELISA; ( E-G ) Flow cytometry detection of IL-6 ( E ), IL-12 ( F ), and TNF-α ( G ) proportions; ( H ) Flow-cytometric analysis of Kupffer-cell phagocytic capacity; ( I ) Western blot detection of SHP2, p-SHP2, STAT1, p-STAT1, NF-κB p65, and p-NF-κB p65. * P < 0.05.

    Journal: Journal of Microbiology and Biotechnology

    Article Title: Anti-PD-1 Therapy Alleviates Klebsiella pneumoniae -Induced Liver Abscess by Effectively Activating Kupffer Cells

    doi: 10.4014/jmb.2602.02040

    Figure Lengend Snippet: ( A ) In vitro bactericidal activity of Kupffer cells against K. pneumoniae evaluated by enumerating viable bacteria; ( B–D ) IL-6 ( B ), IL-12 ( C ), and TNF-α ( D ) levels measured by ELISA; ( E-G ) Flow cytometry detection of IL-6 ( E ), IL-12 ( F ), and TNF-α ( G ) proportions; ( H ) Flow-cytometric analysis of Kupffer-cell phagocytic capacity; ( I ) Western blot detection of SHP2, p-SHP2, STAT1, p-STAT1, NF-κB p65, and p-NF-κB p65. * P < 0.05.

    Article Snippet: The concentrations of TNF-α (E-EL-M3063, Elabscience, China), IL-6 (E-EL-M0044, Elabscience, China), and IL-12 (E-EL-M3062, Elabscience, China) in the supernatant were determined with ELISA kits.

    Techniques: In Vitro, Activity Assay, Bacteria, Enzyme-linked Immunosorbent Assay, Flow Cytometry, Analysis, Western Blot

    ALOS ameliorates gut barrier function and promotes IL-22 production. A C-reactive protein (hs-CRP). B LPS. C Tumour necrosis factor-alpha (TNF-α). D Interleukin-6 (IL-6). E Interleukin 1β (IL-1β). F Interleukin 10 (IL-10). G Representative AB-PAS staining of ileum pathological sections (scale bar, 100 μm, n = 4). H Plasma IL-23. I Plasma IL-22. J Representative immunofluorescent staining of IL-22 in the ileum. n = 4 mice for each group. Scale bar, 20 μm. K Western blotting of the IL-22 and β-actin levels in the ileum tissue of ApoE −/− mice. *P < 0.05; **P < 0.01. One-way ANOVA (with Tukey's HSD) test in A–I. Unpaired t-test in J–K.

    Journal: Natural Products and Bioprospecting

    Article Title: Diversity of oligosaccharides in lipooligosaccharides of Akkermansia muciniphila and its anti-atherosclerotic activity

    doi: 10.1007/s13659-026-00612-4

    Figure Lengend Snippet: ALOS ameliorates gut barrier function and promotes IL-22 production. A C-reactive protein (hs-CRP). B LPS. C Tumour necrosis factor-alpha (TNF-α). D Interleukin-6 (IL-6). E Interleukin 1β (IL-1β). F Interleukin 10 (IL-10). G Representative AB-PAS staining of ileum pathological sections (scale bar, 100 μm, n = 4). H Plasma IL-23. I Plasma IL-22. J Representative immunofluorescent staining of IL-22 in the ileum. n = 4 mice for each group. Scale bar, 20 μm. K Western blotting of the IL-22 and β-actin levels in the ileum tissue of ApoE −/− mice. *P < 0.05; **P < 0.01. One-way ANOVA (with Tukey's HSD) test in A–I. Unpaired t-test in J–K.

    Article Snippet: The interleukin-6 (IL-6) (SEKM-0007; Solarbio), tumor necrosis factor-alpha (TNF-α) (RK00027; Abclonal), interleukin-1β (IL-1β) (MM-0040M1; MEIMIAN), interleukin-10 (IL-10) (1418033–25-6; Solarbio), interleukin-22 (IL-22) (E-MSEL-M0040; Elabscience BiotechnologyCo., Ltd.), interleukin-23 (IL-23) (RK00017; Abclonal), oxidized LDL (ox-LDL), very low density lipoprotein cholesterol (VLDL) (ml037709-2; Mlbio), and lipopolysaccharide (LPS) (WLCSJZF202535; AMOY LUNCHANGSHUO) levels in the plasma and ileum were determined in commercial ELISA kits.

    Techniques: Staining, Clinical Proteomics, Western Blot