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hydroxychloroquine hcq  (MedChemExpress)


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    MedChemExpress hydroxychloroquine hcq
    Hydroxychloroquine Hcq, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hydroxychloroquine hcq/product/MedChemExpress
    Average 94 stars, based on 28 article reviews
    hydroxychloroquine hcq - by Bioz Stars, 2026-05
    94/100 stars

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    Identification and enrichment analysis of therapeutic targets for <t>hydroxychloroquine–sulfasalazine</t> in reversing paclitaxel–platinum chemoresistance. (A) Heatmap showing expression patterns of the top 10 most significant DEGs. (B) Venn diagram identifying core therapeutic targets for the <t>hydroxychloroquine–sulfasalazine</t> combination in reversing paclitaxel–platinum chemoresistance. (C) GO enrichment analysis of overlapping targets. (D) KEGG pathway enrichment of overlapping targets. DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.
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    Image Search Results


    Identification and enrichment analysis of therapeutic targets for hydroxychloroquine–sulfasalazine in reversing paclitaxel–platinum chemoresistance. (A) Heatmap showing expression patterns of the top 10 most significant DEGs. (B) Venn diagram identifying core therapeutic targets for the hydroxychloroquine–sulfasalazine combination in reversing paclitaxel–platinum chemoresistance. (C) GO enrichment analysis of overlapping targets. (D) KEGG pathway enrichment of overlapping targets. DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.

    Journal: Frontiers in Immunology

    Article Title: Reversing chemoresistance in ovarian cancer: network pharmacology reveals how hydroxychloroquine/sulfasalazine duotherapy remodels tumor inflammatory–immune microenvironment

    doi: 10.3389/fimmu.2026.1790210

    Figure Lengend Snippet: Identification and enrichment analysis of therapeutic targets for hydroxychloroquine–sulfasalazine in reversing paclitaxel–platinum chemoresistance. (A) Heatmap showing expression patterns of the top 10 most significant DEGs. (B) Venn diagram identifying core therapeutic targets for the hydroxychloroquine–sulfasalazine combination in reversing paclitaxel–platinum chemoresistance. (C) GO enrichment analysis of overlapping targets. (D) KEGG pathway enrichment of overlapping targets. DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.

    Article Snippet: The compounds were sourced as follows: SSZ (HY-14655), HCQ (HY-W031727), NIC (HY-B0497), and CDDP (HY-17394) from MedChemExpress (Monmouth Junction, NJ, USA); and ATO from Harbin Medical University Pharmaceutical Co., Ltd. (Heilongjiang, China).

    Techniques: Biomarker Discovery, Expressing

    Molecular docking of sulfasalazine and hydroxychloroquine with target proteins. (A) Two-dimensional structural representation of sulfasalazine. (B) Docking pose of sulfasalazine with CCL2, with (C) the binding site magnified. (D) Docking pose of sulfasalazine with CCND1, with (E) the binding site magnified. (F) Docking pose of sulfasalazine with IL1B, with (G) the binding site magnified. (H) Docking pose of sulfasalazine with IL6R, with (I) the binding site magnified. (J) Docking pose of sulfasalazine with TNF, with (K) the binding site magnified. (L) Two-dimensional structural representation of hydroxychloroquine. (M) Docking pose of hydroxychloroquine with CCL2, with (N) the binding site magnified. (O) Docking pose of hydroxychloroquine with CCND1, with (P) the binding site magnified. (Q) Docking pose of hydroxychloroquine with IL1B, with (R) the binding site magnified. (S) Docking pose of hydroxychloroquine with IL6R, with (T) the binding site magnified. (U) Docking pose of hydroxychloroquine with TNF, with (V) the binding site magnified.

    Journal: Frontiers in Immunology

    Article Title: Reversing chemoresistance in ovarian cancer: network pharmacology reveals how hydroxychloroquine/sulfasalazine duotherapy remodels tumor inflammatory–immune microenvironment

    doi: 10.3389/fimmu.2026.1790210

    Figure Lengend Snippet: Molecular docking of sulfasalazine and hydroxychloroquine with target proteins. (A) Two-dimensional structural representation of sulfasalazine. (B) Docking pose of sulfasalazine with CCL2, with (C) the binding site magnified. (D) Docking pose of sulfasalazine with CCND1, with (E) the binding site magnified. (F) Docking pose of sulfasalazine with IL1B, with (G) the binding site magnified. (H) Docking pose of sulfasalazine with IL6R, with (I) the binding site magnified. (J) Docking pose of sulfasalazine with TNF, with (K) the binding site magnified. (L) Two-dimensional structural representation of hydroxychloroquine. (M) Docking pose of hydroxychloroquine with CCL2, with (N) the binding site magnified. (O) Docking pose of hydroxychloroquine with CCND1, with (P) the binding site magnified. (Q) Docking pose of hydroxychloroquine with IL1B, with (R) the binding site magnified. (S) Docking pose of hydroxychloroquine with IL6R, with (T) the binding site magnified. (U) Docking pose of hydroxychloroquine with TNF, with (V) the binding site magnified.

    Article Snippet: The compounds were sourced as follows: SSZ (HY-14655), HCQ (HY-W031727), NIC (HY-B0497), and CDDP (HY-17394) from MedChemExpress (Monmouth Junction, NJ, USA); and ATO from Harbin Medical University Pharmaceutical Co., Ltd. (Heilongjiang, China).

    Techniques: Binding Assay

    Integrated pharmacologic and cytokine profiling in ovarian cancer. (A–E) Dose–response curves for (A) arsenic trioxide (ATO; PML-RARα degrader), (B) hydroxychloroquine (HCQ; autophagy inhibitor), (C) cisplatin (CDDP; DNA crosslinker), (D) niclosamide (NIC; Signal transducer and activator of transcription 3 (STAT3)/Wnt signaling inhibitor), and (E) sulfasalazine (SSZ; NF-κB/glutathione inhibitor); all agents reduced cell viability in a dose-dependent manner. IC 50 values are log-transformed (μM). (F–H) Retrospective serum cytokine profiling revealed higher IL-6, IL-8, and IL-10 levels in HGSOC patients with autoimmune disease than in those without, shown for (F) IL-6, (G) IL-8, and (H) IL-10. (I–K) In patients without autoimmune disease, ascites cytokine concentrations were higher than matched serum levels, shown for (I) IL-6, (J) IL-8, and (K) IL-10.All boxplots show medians, interquartile ranges, and individual data points. Welch’s t-tests were used for between-group comparisons.

    Journal: Frontiers in Immunology

    Article Title: Reversing chemoresistance in ovarian cancer: network pharmacology reveals how hydroxychloroquine/sulfasalazine duotherapy remodels tumor inflammatory–immune microenvironment

    doi: 10.3389/fimmu.2026.1790210

    Figure Lengend Snippet: Integrated pharmacologic and cytokine profiling in ovarian cancer. (A–E) Dose–response curves for (A) arsenic trioxide (ATO; PML-RARα degrader), (B) hydroxychloroquine (HCQ; autophagy inhibitor), (C) cisplatin (CDDP; DNA crosslinker), (D) niclosamide (NIC; Signal transducer and activator of transcription 3 (STAT3)/Wnt signaling inhibitor), and (E) sulfasalazine (SSZ; NF-κB/glutathione inhibitor); all agents reduced cell viability in a dose-dependent manner. IC 50 values are log-transformed (μM). (F–H) Retrospective serum cytokine profiling revealed higher IL-6, IL-8, and IL-10 levels in HGSOC patients with autoimmune disease than in those without, shown for (F) IL-6, (G) IL-8, and (H) IL-10. (I–K) In patients without autoimmune disease, ascites cytokine concentrations were higher than matched serum levels, shown for (I) IL-6, (J) IL-8, and (K) IL-10.All boxplots show medians, interquartile ranges, and individual data points. Welch’s t-tests were used for between-group comparisons.

    Article Snippet: The compounds were sourced as follows: SSZ (HY-14655), HCQ (HY-W031727), NIC (HY-B0497), and CDDP (HY-17394) from MedChemExpress (Monmouth Junction, NJ, USA); and ATO from Harbin Medical University Pharmaceutical Co., Ltd. (Heilongjiang, China).

    Techniques: Transformation Assay