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normal human primary prostate epithelial cells hprec  (ATCC)


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    ATCC normal human primary prostate epithelial cells hprec
    Normal Human Primary Prostate Epithelial Cells Hprec, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 552 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hprec/Primary+Prostate+Epithelial+Cells%3B+Normal%2C+Human/pm42203130-74-0-11
    Average 99 stars, based on 552 article reviews
    normal human primary prostate epithelial cells hprec - by Bioz Stars, 2026-11
    99/100 stars

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    Cell Culture:

    Article Title: Long non-coding RNA SNHG17 enhances the aggressiveness of C4-2 human prostate cancer cells in association with β-catenin signaling
    Article Snippet: .. The human prostate cancer cell lines LNCaP [clone FGC; CRL-1740; American Type Culture Collection (ATCC)] and C4-2 (CRL-3314; ATCC), and the normal human prostate epithelial cell line, HPrEC (PCS-440-010; ATCC) were cultured in DMEM (Invitrogen; Thermo Fisher Scientific, Inc.) supplemented with 10% FCS (Invitrogen; Thermo Fisher Scientific, Inc.) at 37°C in a humidified incubator with 5% CO 2 . .. For SNHG17 knockdown, recombinant lentivirus-mediated SNHG17-short hairpin (sh)RNA vectors (Lv-SNHG17-shRNA; Sangon Biotech, Co., Ltd.) were prepared.

    Article Title: Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers
    Article Snippet: C4-2B (ATCC, CRL-3314, RRID:CVCL_4784), 22Rv1 cells (ATCC, CRL-2505, RRID:CVCL_1045), VCaP (ATCC, CRL2876, RRID:CVCL_2235), LNCaP (ATCC, CRL-1740, RRID:CVCL_0395), LNCaP95 (gift from Stephen Plymate, University of Washington (Seattle, WA), RRID:CVCL_ZC87), LAPC4 (gift from Robert Reiter, UCLA, RRID:CVCL_4744), PC3 (ATCC, CRL-1435, RRID:CVCL_0035), and DU145 (ATCC, HTB-81, RRID:CVCL_0105) cell lines were maintained in RPMI1640 Media or DMEM (Gibco, Life Technologies) with 10% FBS (Atlanta Biologicals) or 10% charcoal-stripped FBS (Thermo Fisher Scientific). .. RWPE-1 (ATCC, CRL-11609, RRID:CVCL_3791) and HPrEC (ATCC, PCS-440-010) were cultured in Keratinocyte Serum Free Medium (Thermo Fisher Scientific) supplemented with 0.05 mg/mL bovine pituitary extract and 5 ng/mL human epidermal growth factor. .. NCI-H660 (ATCC, CRL-5813, RRID:CVCL_1576), MSKCC EF1 (gift from Yu Chen, Memorial Sloan Kettering Cancer Center), and LASCPC-01 (ATCC, CL-3356, RRID:CVCL_UE17) cell lines were maintained in HITES media (ATCC) with 5% FBS (Atlanta Biologicals).

    Article Title: Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase
    Article Snippet: .. HPrEC (ATCC PCS-440-010), immortalized hPrEC T-ΔN2A clones, and EP156T cells (ATCC CRL-3289) were cultured in prostate epithelial medium supplemented with growth factors (ATCC PCS-440-040). .. All other cell lines were obtained from ATCC and tested for mycoplasma regularly.

    Article Title: Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers
    Article Snippet: C4-2B (ATCC, CRL-3314, RRID:CVCL_4784), 22Rv1 cells (ATCC, CRL-2505, RRID:CVCL_1045), VCaP (ATCC, CRL-2876, RRID:CVCL_2235), LNCaP (ATCC, CRL-1740, RRID:CVCL_0395), LNCaP95 (gift from Stephen Plymate, University of Washington (Seattle, WA), RRID:CVCL_ZC87), LAPC4 (gift from Robert Reiter, UCLA, RRID:CVCL_4744), PC3 (ATCC, CRL-1435, RRID:CVCL_0035), and DU145 (ATCC, HTB-81, RRID:CVCL_0105) cell lines were maintained in RPMI1640 Media or DMEM (Gibco, Life Technologies) with 10% FBS (Atlanta Biologicals) or 10% charcoal-stripped FBS (Thermo Fisher Scientific). .. RWPE-1 (ATCC, CRL-11609, RRID:CVCL_3791) and HPrEC (ATCC, PCS-440-010) were cultured in Keratinocyte Serum Free Medium (Thermo Fisher Scientific) supplemented with 0.05 mg/mL bovine pituitary extract and 5 ng/mL human epidermal growth factor. .. NCI-H660 (ATCC, CRL-5813, RRID:CVCL_1576), MSKCC EF1 (gift from Yu Chen, Memorial Sloan Kettering Cancer Center), and LASCPC-01 (ATCC, CL-3356, RRID:CVCL_UE17) cell lines were maintained in HITES media (ATCC) with 5% FBS (Atlanta Biologicals).

    Clone Assay:

    Article Title: Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase
    Article Snippet: .. HPrEC (ATCC PCS-440-010), immortalized hPrEC T-ΔN2A clones, and EP156T cells (ATCC CRL-3289) were cultured in prostate epithelial medium supplemented with growth factors (ATCC PCS-440-040). .. All other cell lines were obtained from ATCC and tested for mycoplasma regularly.



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    normal human primary prostate epithelial cells hprec  (ATCC)
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    ATCC normal human primary prostate epithelial cells hprec
    Normal Human Primary Prostate Epithelial Cells Hprec, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    normal human prostate epithelial cells hprec  (ATCC)
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    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and <t>HPrEC</t> following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate <t>epithelial</t> cells; GEN: genistein; BTN: butein; Conc.: concentration.
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    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and <t>HPrEC</t> following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate <t>epithelial</t> cells; GEN: genistein; BTN: butein; Conc.: concentration.
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    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and <t>HPrEC</t> following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate <t>epithelial</t> cells; GEN: genistein; BTN: butein; Conc.: concentration.
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    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and <t>HPrEC</t> following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate <t>epithelial</t> cells; GEN: genistein; BTN: butein; Conc.: concentration.
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    preparation hprec  (ATCC)
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    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and <t>HPrEC</t> following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate <t>epithelial</t> cells; GEN: genistein; BTN: butein; Conc.: concentration.
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    ATCC hprec
    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and <t>HPrEC</t> following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate <t>epithelial</t> cells; GEN: genistein; BTN: butein; Conc.: concentration.
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    Image Search Results


    Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and HPrEC following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein; Conc.: concentration.

    Journal: Current Issues in Molecular Biology

    Article Title: Genistein–Butein Co-Treatment Suppresses Glycolytic Metabolism and Induces Apoptotic Signaling in PC-3 Prostate Cancer Cells

    doi: 10.3390/cimb48030258

    Figure Lengend Snippet: Genistein and butein reduce cell viability in prostate cancer cells. ( A ) Chemical structures of GEN and BTN. ( B ) Viability of PC-3 prostate cancer cells and HPrEC following exposure to increasing concentrations of GEN or BTN for 24 or 48 h, evaluated using the MTT assay. ( C ) Cell viability measured by means of trypan blue exclusion under identical treatment conditions. Results are normalized to untreated controls, and IC 50 values were calculated from 48 h treatment data where indicated. Values represent the mean ± SD of at least three independent experiments; * p < 0.05 versus control. HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein; Conc.: concentration.

    Article Snippet: Human prostate cancer PC-3 cells and normal human prostate epithelial cells (HPrEC) were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA).

    Techniques: MTT Assay, Control, Concentration Assay

    Combined genistein and butein treatment impairs glycolytic metabolism in PC-3 cells. HPrEC and PC-3 cells were treated with GEN, BTN, or GEN/BTN for 48 h. ( A , B ) Extracellular lactate production and glucose consumption were quantified and normalized to control levels. Enzymatic activities of hexokinase (HK) and pyruvate dehydrogenase (PDH) were assessed following treatment. GEN/BTN co-treatment produced a pronounced suppression of glycolytic activity in PC-3 cells, whereas metabolic parameters in HPrEC cells remained largely unchanged. Data are shown as the mean ± SD (n = 3). Statistical significance is indicated by asterisks (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001). HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein.

    Journal: Current Issues in Molecular Biology

    Article Title: Genistein–Butein Co-Treatment Suppresses Glycolytic Metabolism and Induces Apoptotic Signaling in PC-3 Prostate Cancer Cells

    doi: 10.3390/cimb48030258

    Figure Lengend Snippet: Combined genistein and butein treatment impairs glycolytic metabolism in PC-3 cells. HPrEC and PC-3 cells were treated with GEN, BTN, or GEN/BTN for 48 h. ( A , B ) Extracellular lactate production and glucose consumption were quantified and normalized to control levels. Enzymatic activities of hexokinase (HK) and pyruvate dehydrogenase (PDH) were assessed following treatment. GEN/BTN co-treatment produced a pronounced suppression of glycolytic activity in PC-3 cells, whereas metabolic parameters in HPrEC cells remained largely unchanged. Data are shown as the mean ± SD (n = 3). Statistical significance is indicated by asterisks (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001). HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein.

    Article Snippet: Human prostate cancer PC-3 cells and normal human prostate epithelial cells (HPrEC) were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA).

    Techniques: Control, Produced, Activity Assay

    Genistein–butein co-treatment decreases ATP levels and clonogenic survival in PC-3 cells. ( A ) Intracellular ATP content was determined after 48 h exposure to GEN, BTN, or GEN/BTN, and expressed relative to control cells (n = 3 independent experiments). ( B ) Crystal violet staining images illustrating treatment-dependent changes in cell survival. ( C ) Quantitative analysis of crystal violet staining measured at 590 nm. Each dot represents an individual replicate, and data are presented as mean ± SD (total n = 8 pooled from at least three independent experiments). Following GEN/BTN co-treatment in PC-3 cells, a significant reduction in ATP production and cell survival was observed, while normal HPrEC cells showed minimal changes. Results represent the mean ± SD from three independent experiments. Statistical significance is indicated by asterisks (* p < 0.05; ** p < 0.01; **** p < 0.0001). HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein.

    Journal: Current Issues in Molecular Biology

    Article Title: Genistein–Butein Co-Treatment Suppresses Glycolytic Metabolism and Induces Apoptotic Signaling in PC-3 Prostate Cancer Cells

    doi: 10.3390/cimb48030258

    Figure Lengend Snippet: Genistein–butein co-treatment decreases ATP levels and clonogenic survival in PC-3 cells. ( A ) Intracellular ATP content was determined after 48 h exposure to GEN, BTN, or GEN/BTN, and expressed relative to control cells (n = 3 independent experiments). ( B ) Crystal violet staining images illustrating treatment-dependent changes in cell survival. ( C ) Quantitative analysis of crystal violet staining measured at 590 nm. Each dot represents an individual replicate, and data are presented as mean ± SD (total n = 8 pooled from at least three independent experiments). Following GEN/BTN co-treatment in PC-3 cells, a significant reduction in ATP production and cell survival was observed, while normal HPrEC cells showed minimal changes. Results represent the mean ± SD from three independent experiments. Statistical significance is indicated by asterisks (* p < 0.05; ** p < 0.01; **** p < 0.0001). HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein.

    Article Snippet: Human prostate cancer PC-3 cells and normal human prostate epithelial cells (HPrEC) were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA).

    Techniques: Control, Staining

    Genistein–butein co-treatment promotes apoptosis and suppresses AKT/ERK signaling in PC-3 cells. ( A ) Apoptotic cell populations were evaluated using Annexin V and viability staining after 48 h treatment. Representative dot plots are shown for HPrEC and PC-3 cells. ( B ) Expression levels of hexokinase II and PDH were analyzed by means of Western blotting, with β-actin serving as a loading control. Corresponding densitometric analyses are presented. ( C ) Phosphorylation status of AKT and ERK, along with levels of cleaved caspase-3 and cleaved PARP, was examined by Western blot analysis. GEN/BTN co-treatment selectively inhibited survival signaling and enhanced apoptotic marker cleavage in PC-3 cells. Data are presented as the mean ± SD. Statistical significance is indicated. Statistical significance is indicated by asterisks (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001). HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein; PDH: pyruvate dehydrogenase.

    Journal: Current Issues in Molecular Biology

    Article Title: Genistein–Butein Co-Treatment Suppresses Glycolytic Metabolism and Induces Apoptotic Signaling in PC-3 Prostate Cancer Cells

    doi: 10.3390/cimb48030258

    Figure Lengend Snippet: Genistein–butein co-treatment promotes apoptosis and suppresses AKT/ERK signaling in PC-3 cells. ( A ) Apoptotic cell populations were evaluated using Annexin V and viability staining after 48 h treatment. Representative dot plots are shown for HPrEC and PC-3 cells. ( B ) Expression levels of hexokinase II and PDH were analyzed by means of Western blotting, with β-actin serving as a loading control. Corresponding densitometric analyses are presented. ( C ) Phosphorylation status of AKT and ERK, along with levels of cleaved caspase-3 and cleaved PARP, was examined by Western blot analysis. GEN/BTN co-treatment selectively inhibited survival signaling and enhanced apoptotic marker cleavage in PC-3 cells. Data are presented as the mean ± SD. Statistical significance is indicated. Statistical significance is indicated by asterisks (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001). HPrEC: normal human prostate epithelial cells; GEN: genistein; BTN: butein; PDH: pyruvate dehydrogenase.

    Article Snippet: Human prostate cancer PC-3 cells and normal human prostate epithelial cells (HPrEC) were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA).

    Techniques: Staining, Expressing, Western Blot, Control, Phospho-proteomics, Marker