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gsk2983559  (TargetMol)


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    TargetMol gsk2983559
    Fig. 2 <t>GSK2983559</t> improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells (D–F) and primary cultured astrocytes (H–J) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells (G) and primary cultured astrocytes subjected to OGD/R (K). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group
    Gsk2983559, supplied by TargetMol, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gsk2983559/GSK2983559+active+metabolite/pm38012669-63-0-1
    Average 91 stars, based on 1 article reviews
    gsk2983559 - by Bioz Stars, 2026-09
    91/100 stars

    Images

    1) Product Images from "OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2."

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.

    Journal: Journal of neuroinflammation

    doi: 10.1186/s12974-023-02968-7

    Fig. 2 GSK2983559 improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells (D–F) and primary cultured astrocytes (H–J) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells (G) and primary cultured astrocytes subjected to OGD/R (K). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group
    Figure Legend Snippet: Fig. 2 GSK2983559 improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells (D–F) and primary cultured astrocytes (H–J) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells (G) and primary cultured astrocytes subjected to OGD/R (K). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group

    Techniques Used: Staining, Western Blot, Cell Culture, Enzyme-linked Immunosorbent Assay

    Related Articles

    Staining:

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Western Blot:

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Cell Culture:

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Enzyme-linked Immunosorbent Assay:

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly-d-lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.. Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.Poly- d -lysine hydrobromide (Sigma, Cat. P0899) and 2, 3, 5-Triphenyltetrazolium chloride (TTC) (Sigma, Cat. T8877) were obtained from Sigma.



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    Fig. 2 <t>GSK2983559</t> improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells (D–F) and primary cultured astrocytes (H–J) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells (G) and primary cultured astrocytes subjected to OGD/R (K). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group
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    Fig. 2 GSK2983559 improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells (D–F) and primary cultured astrocytes (H–J) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells (G) and primary cultured astrocytes subjected to OGD/R (K). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group

    Journal: Journal of neuroinflammation

    Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.

    doi: 10.1186/s12974-023-02968-7

    Figure Lengend Snippet: Fig. 2 GSK2983559 improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells (D–F) and primary cultured astrocytes (H–J) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells (G) and primary cultured astrocytes subjected to OGD/R (K). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05 compared with indicated group

    Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.

    Techniques: Staining, Western Blot, Cell Culture, Enzyme-linked Immunosorbent Assay