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grl0617  (MedChemExpress)


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    MedChemExpress grl0617
    Grl0617, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/grl0617/pm41534899-274-3-7?v=MedChemExpress
    Average 94 stars, based on 7 article reviews
    grl0617 - by Bioz Stars, 2026-08
    94/100 stars

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    Image Search Results


    Structures of the first reported PL Pro inhibitor GRL-0617 and its analogues developed by University of Illinois 1 , Rutgers University 2 & 5 , , Pfizer 3 , and Oakridge National Laboratory 4 with their inhibitory and cellular activity reported. Structure of peptide based irreversible inhibitor VIR250 developed by the NIH.

    Journal: Journal of Medicinal Chemistry

    Article Title: Discovery of Spiro[chromane-2,4′-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV‑2 Papain-like Protease

    doi: 10.1021/acs.jmedchem.5c03704

    Figure Lengend Snippet: Structures of the first reported PL Pro inhibitor GRL-0617 and its analogues developed by University of Illinois 1 , Rutgers University 2 & 5 , , Pfizer 3 , and Oakridge National Laboratory 4 with their inhibitory and cellular activity reported. Structure of peptide based irreversible inhibitor VIR250 developed by the NIH.

    Article Snippet: GRL-0617 served as a PL Pro positive control inhibitor (Selleckchem).

    Techniques: Analogues, Activity Assay