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fingolimod  (Novartis)

 
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    Novartis fingolimod
    Fingolimod, supplied by Novartis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gilenya/us12655186-1300-41-43?v=Novartis
    Average 86 stars, based on 1 article reviews
    fingolimod - by Bioz Stars, 2026-08
    86/100 stars

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    Inhibitory effect of fingolimod on biofilm formation by A. baumannii KBN12P01964. Biofilms were stained with 0.5% crystal violet, and absorbance was measured at 595 nm. Absorbance values were normalized to the DMSO-treated control and expressed as percentages. The maximum concentration of fingolimod tested in this experiment was set at its MIC (8 μg/mL). Data are presented as individual values (●), with error bars representing the mean ± standard deviation (SD) of six independent experiments ( N = 6). Statistical significance was determined by one-way analysis of variance (ANOVA), and differences from the control were considered significant at *** p < 0.001.

    Journal: ACS Omega

    Article Title: Repurposing Fingolimod as an Antibacterial and Antibiofilm Agent against Carbapenem-Resistant Acinetobacter baumannii

    doi: 10.1021/acsomega.5c12513

    Figure Lengend Snippet: Inhibitory effect of fingolimod on biofilm formation by A. baumannii KBN12P01964. Biofilms were stained with 0.5% crystal violet, and absorbance was measured at 595 nm. Absorbance values were normalized to the DMSO-treated control and expressed as percentages. The maximum concentration of fingolimod tested in this experiment was set at its MIC (8 μg/mL). Data are presented as individual values (●), with error bars representing the mean ± standard deviation (SD) of six independent experiments ( N = 6). Statistical significance was determined by one-way analysis of variance (ANOVA), and differences from the control were considered significant at *** p < 0.001.

    Article Snippet: Fingolimod was purchased from TCI Ltd. (Tokyo, Japan).

    Techniques: Staining, Control, Concentration Assay, Standard Deviation

    Eradication effect of fingolimod on mature biofilms of A. baumannii KBN12P01964. Biofilms were established prior to fingolimod treatment, and residual biomass was quantified by 0.5% crystal violet staining. Absorbance was measured at 595 nm was assessed and expressed as a percentage relative the DMSO-treated control. The highest concentration of fingolimod tested in this experiment was set at its MIC (8 μg/mL). Data are presented as individual values (●), with error bars representing the mean ± SD of six independent experiments ( N = 6). Statistical significance was determined by one-way ANOVA; with *** p < 0.001 indicates a significant difference compared with the control.

    Journal: ACS Omega

    Article Title: Repurposing Fingolimod as an Antibacterial and Antibiofilm Agent against Carbapenem-Resistant Acinetobacter baumannii

    doi: 10.1021/acsomega.5c12513

    Figure Lengend Snippet: Eradication effect of fingolimod on mature biofilms of A. baumannii KBN12P01964. Biofilms were established prior to fingolimod treatment, and residual biomass was quantified by 0.5% crystal violet staining. Absorbance was measured at 595 nm was assessed and expressed as a percentage relative the DMSO-treated control. The highest concentration of fingolimod tested in this experiment was set at its MIC (8 μg/mL). Data are presented as individual values (●), with error bars representing the mean ± SD of six independent experiments ( N = 6). Statistical significance was determined by one-way ANOVA; with *** p < 0.001 indicates a significant difference compared with the control.

    Article Snippet: Fingolimod was purchased from TCI Ltd. (Tokyo, Japan).

    Techniques: Staining, Control, Concentration Assay

    Changes in the metabolic activity of A. baumannii KBN12P01964 within biofilms following fingolimod treatment. Metabolic activity gradually decreased in a concentration-dependent manner. Values were calculated using the formula: A 475 nm (test) – A 475 nm (blank) – A 660 nm (test), and expressed as percentages relative to the control. Data are presented as individual values (●), with error bars indicating the mean ± SD of six independent experiments ( N = 6). Statistical significance was determined by one-way ANOVA, with *** p < 0.001 versus the control.

    Journal: ACS Omega

    Article Title: Repurposing Fingolimod as an Antibacterial and Antibiofilm Agent against Carbapenem-Resistant Acinetobacter baumannii

    doi: 10.1021/acsomega.5c12513

    Figure Lengend Snippet: Changes in the metabolic activity of A. baumannii KBN12P01964 within biofilms following fingolimod treatment. Metabolic activity gradually decreased in a concentration-dependent manner. Values were calculated using the formula: A 475 nm (test) – A 475 nm (blank) – A 660 nm (test), and expressed as percentages relative to the control. Data are presented as individual values (●), with error bars indicating the mean ± SD of six independent experiments ( N = 6). Statistical significance was determined by one-way ANOVA, with *** p < 0.001 versus the control.

    Article Snippet: Fingolimod was purchased from TCI Ltd. (Tokyo, Japan).

    Techniques: Activity Assay, Concentration Assay, Control

    Impact of fingolimod on cell viability and structural integrity and of mature A. baumannii biofilms. (A) CLSM images showing cell viability within mature A. baumannii KBN12P01964 biofilms stained with SYTO 9 (green) and PI (red) following fingolimod treatment. SYTO 9 stains metabolically viable cells, whereas PI stains nonviable cells. Images were acquired at ×63 magnification using a Zeiss LSM900 microscope equipped with Airyscan 2 and processed using ZEN software. (B) Biofilm structural parameters were quantified by COMSTAT 2 analysis. Data are presented as individual values (●), with error bars representing the mean ± SD of three independent experiments ( N = 3). Statistical significance was determined by one-way ANOVA, with * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to the control.

    Journal: ACS Omega

    Article Title: Repurposing Fingolimod as an Antibacterial and Antibiofilm Agent against Carbapenem-Resistant Acinetobacter baumannii

    doi: 10.1021/acsomega.5c12513

    Figure Lengend Snippet: Impact of fingolimod on cell viability and structural integrity and of mature A. baumannii biofilms. (A) CLSM images showing cell viability within mature A. baumannii KBN12P01964 biofilms stained with SYTO 9 (green) and PI (red) following fingolimod treatment. SYTO 9 stains metabolically viable cells, whereas PI stains nonviable cells. Images were acquired at ×63 magnification using a Zeiss LSM900 microscope equipped with Airyscan 2 and processed using ZEN software. (B) Biofilm structural parameters were quantified by COMSTAT 2 analysis. Data are presented as individual values (●), with error bars representing the mean ± SD of three independent experiments ( N = 3). Statistical significance was determined by one-way ANOVA, with * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to the control.

    Article Snippet: Fingolimod was purchased from TCI Ltd. (Tokyo, Japan).

    Techniques: Staining, Metabolic Labelling, Microscopy, Software, Control

    Inhibitory effect of fingolimod on the expression of biofilm-associated genes in A. baumannii KBN12P01964. (A) Expression of the chaperone-usher pili gene csuA / B . (B) Expression of the two-component regulatory system gene bfmR . (C) Expression of the biofilm-associated protein gene bap . (D) Expression of the outer membrane protein A gene ompA . Relative gene expression levels were normalized to 16S rRNA. Data are presented as individual values (●), with error bars indicating the mean ± SD of six independent experiments ( N = 6). Statistical significance was determined by one-way ANOVA, with ** p < 0.01 and *** p < 0.001 compared with the control.

    Journal: ACS Omega

    Article Title: Repurposing Fingolimod as an Antibacterial and Antibiofilm Agent against Carbapenem-Resistant Acinetobacter baumannii

    doi: 10.1021/acsomega.5c12513

    Figure Lengend Snippet: Inhibitory effect of fingolimod on the expression of biofilm-associated genes in A. baumannii KBN12P01964. (A) Expression of the chaperone-usher pili gene csuA / B . (B) Expression of the two-component regulatory system gene bfmR . (C) Expression of the biofilm-associated protein gene bap . (D) Expression of the outer membrane protein A gene ompA . Relative gene expression levels were normalized to 16S rRNA. Data are presented as individual values (●), with error bars indicating the mean ± SD of six independent experiments ( N = 6). Statistical significance was determined by one-way ANOVA, with ** p < 0.01 and *** p < 0.001 compared with the control.

    Article Snippet: Fingolimod was purchased from TCI Ltd. (Tokyo, Japan).

    Techniques: Expressing, Membrane, Gene Expression, Control