gemcitabine (MedChemExpress)
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Gemcitabine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 227 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gemcitabine/Gemcitabine/bio_rxiv__64898__2026__07__21__736123-206-9-28
Average 97 stars, based on 227 article reviews
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1) Product Images from "Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia"
Article Title: Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia
Journal: bioRxiv
doi: 10.64898/2026.07.21.736123
Figure Legend Snippet: A-B . Clofarabine treatment effectively reversed AC220 (A) and gilteritinib (B) resistance in SPRY3 KO/ FLT3 ITD + MV4-11 AML cells. C-D. Clofarabine treatment effectively reversed AC220 (C) and gilteritinib (D) resistance in NRAS mut / FLT3 ITD + MV4-11 AML cells. E. Clofarabine alone exhibited minimal cytotoxicity in MV4-11 AML cells. F-H. Additional RNRis, including fludarabine, gemcitabine, and hydroxyurea, also effectively reversed gilteritinib resistance in NRAS mut / FLT3 ITD + MV4-11 AML cells. I . Cladribine, a clinically approved purine nucleoside analog and indirect RNR inhibitor, reversed FLT3i resistance in NRAS mut / FLT3 ITD + AML cells. J. Triapine, a potent RNRi, reversed FLT3i resistance in NRAS mut / FLT3 ITD + MV4-11 AML cells. K. Nelarabine, an RNR activator, induced FLT3i resistance in NRAS WT MV4-11 AML cells; this effect was reversed by clofarabine. Data represent the means ± SD of three replicates.
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