Journal: Pharmaceutics
Article Title: Abiraterone and Galeterone, Powerful Tools Against Prostate Cancer: Present and Perspective
doi: 10.3390/pharmaceutics16111401
Figure Lengend Snippet: Synthesis of galeterone ( 3 ) from dehydroepiandrosterone acetate ( 4 ). Reagents and conditions: (a) POCl 3 -DMF, CH 3 Cl, Ar, reflux; (b) benzimidazole, K 2 CO 3 , DMF, Ar, 80 °C; (c) 10% Pd on activated charcoal, PhCN, reflux; (d) 10% methanolic KOH, Ar, rt.
Article Snippet: These data enabled galeterone to be licensed to Tokai Pharmaceuticals Inc., Cambridge, MA, for further preclinical and clinical studies and granted it a new code name, TOK-001 [ ].
Techniques: Reflux