Review



gaba a antagonist gabazine  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 96
      Buy from Supplier

    Structured Review

    Tocris gaba a antagonist gabazine
    Gaba A Antagonist Gabazine, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 990 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gaba a antagonist gabazine/product/Tocris
    Average 96 stars, based on 990 article reviews
    gaba a antagonist gabazine - by Bioz Stars, 2026-06
    96/100 stars

    Images



    Similar Products

    ohda medchem express cat  (MedChemExpress)
    94
    MedChemExpress ohda medchem express cat
    Ohda Medchem Express Cat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ohda medchem express cat/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    ohda medchem express cat - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    gaba a antagonist gabazine  (Tocris)
    96
    Tocris gaba a antagonist gabazine
    Gaba A Antagonist Gabazine, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gaba a antagonist gabazine/product/Tocris
    Average 96 stars, based on 1 article reviews
    gaba a antagonist gabazine - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    gabazine hydrobromide  (Tocris)
    96
    Tocris gabazine hydrobromide
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Gabazine Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gabazine hydrobromide/product/Tocris
    Average 96 stars, based on 1 article reviews
    gabazine hydrobromide - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    gabaa receptor antagonist sr 95531  (MedChemExpress)
    94
    MedChemExpress gabaa receptor antagonist sr 95531
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Gabaa Receptor Antagonist Sr 95531, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gabaa receptor antagonist sr 95531/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    gabaa receptor antagonist sr 95531 - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    huvecs  (MedChemExpress)
    94
    MedChemExpress huvecs
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Huvecs, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/huvecs/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    huvecs - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    gabaa receptor antagonist sr95531  (MedChemExpress)
    94
    MedChemExpress gabaa receptor antagonist sr95531
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Gabaa Receptor Antagonist Sr95531, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gabaa receptor antagonist sr95531/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    gabaa receptor antagonist sr95531 - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    sr95531  (Tocris)
    96
    Tocris sr95531
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Sr95531, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sr95531/product/Tocris
    Average 96 stars, based on 1 article reviews
    sr95531 - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    95531 hydrobromide  (Tocris)
    96
    Tocris 95531 hydrobromide
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    95531 Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/95531 hydrobromide/product/Tocris
    Average 96 stars, based on 1 article reviews
    95531 hydrobromide - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    gabazine  (MedChemExpress)
    94
    MedChemExpress gabazine
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Gabazine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gabazine/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    gabazine - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    gabazine  (Tocris)
    96
    Tocris gabazine
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Gabazine, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gabazine/product/Tocris
    Average 96 stars, based on 1 article reviews
    gabazine - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of gabazine (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.

    Journal: bioRxiv

    Article Title: P2X7 receptor-mediated astrocytic atrophy in the hippocampus of mice after status epilepticus

    doi: 10.64898/2026.04.16.718853

    Figure Lengend Snippet: Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of gabazine (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.

    Article Snippet: The drugs used were the following: JNJ-47965567, gabazine hydrobromide (Tocris Biosciences, Bristol, UK); kainic acid hydrate (MedChem Express, Monmouth Junction, NJ, USA); diazepam (Shanghai Xudong Haipu Pharmaceutical Co., Shanghai, China).

    Techniques: