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Figure 1: Depletion of TMEM135 decreases lipid accumulation in the liver of HFD mice and FFA-treated primary hepatocytes and AML12 cells. (AeC) WT and TMEM135KO mice were fed either NCD or HFD for 22 weeks (n ¼ 6 per group). (A) Oil Red O staining of liver tissue section (Original magnification x100). (B) Immunoblots and densitometry for PLIN2, <t>FSP27,</t> and b-actin from the liver tissue of mice. Data represent mean SD, **p < 0.01, *p < 0.05, Two-way ANOVA. (C) Hepatic TG levels. Data represent mean SD, **p < 0.01, Two-way ANOVA. (DeF) Primary hepatocytes were isolated from the livers of WT and TMEM135KO mice and treated with FFA for 12 h. (D) Oil Red O staining and quantification of LD area (Original magnification x40, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (E) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, ***p < 0.001, Two- way ANOVA. (F) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (GeI) sh-Scramble and sh-TMEM135 cells were treated with FFA for 12 h. (G) Oil Red O staining and quantification of LD area (Original magnification x100, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (H) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (I) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Figure 1: Depletion of TMEM135 decreases lipid accumulation in the liver of HFD mice and FFA-treated primary hepatocytes and AML12 cells. (AeC) WT and TMEM135KO mice were fed either NCD or HFD for 22 weeks (n ¼ 6 per group). (A) Oil Red O staining of liver tissue section (Original magnification x100). (B) Immunoblots and densitometry for PLIN2, <t>FSP27,</t> and b-actin from the liver tissue of mice. Data represent mean SD, **p < 0.01, *p < 0.05, Two-way ANOVA. (C) Hepatic TG levels. Data represent mean SD, **p < 0.01, Two-way ANOVA. (DeF) Primary hepatocytes were isolated from the livers of WT and TMEM135KO mice and treated with FFA for 12 h. (D) Oil Red O staining and quantification of LD area (Original magnification x40, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (E) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, ***p < 0.001, Two- way ANOVA. (F) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (GeI) sh-Scramble and sh-TMEM135 cells were treated with FFA for 12 h. (G) Oil Red O staining and quantification of LD area (Original magnification x100, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (H) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (I) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Figure 1: Depletion of TMEM135 decreases lipid accumulation in the liver of HFD mice and FFA-treated primary hepatocytes and AML12 cells. (AeC) WT and TMEM135KO mice were fed either NCD or HFD for 22 weeks (n ¼ 6 per group). (A) Oil Red O staining of liver tissue section (Original magnification x100). (B) Immunoblots and densitometry for PLIN2, <t>FSP27,</t> and b-actin from the liver tissue of mice. Data represent mean SD, **p < 0.01, *p < 0.05, Two-way ANOVA. (C) Hepatic TG levels. Data represent mean SD, **p < 0.01, Two-way ANOVA. (DeF) Primary hepatocytes were isolated from the livers of WT and TMEM135KO mice and treated with FFA for 12 h. (D) Oil Red O staining and quantification of LD area (Original magnification x40, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (E) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, ***p < 0.001, Two- way ANOVA. (F) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (GeI) sh-Scramble and sh-TMEM135 cells were treated with FFA for 12 h. (G) Oil Red O staining and quantification of LD area (Original magnification x100, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (H) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (I) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Figure 1: Depletion of TMEM135 decreases lipid accumulation in the liver of HFD mice and FFA-treated primary hepatocytes and AML12 cells. (AeC) WT and TMEM135KO mice were fed either NCD or HFD for 22 weeks (n ¼ 6 per group). (A) Oil Red O staining of liver tissue section (Original magnification x100). (B) Immunoblots and densitometry for PLIN2, <t>FSP27,</t> and b-actin from the liver tissue of mice. Data represent mean SD, **p < 0.01, *p < 0.05, Two-way ANOVA. (C) Hepatic TG levels. Data represent mean SD, **p < 0.01, Two-way ANOVA. (DeF) Primary hepatocytes were isolated from the livers of WT and TMEM135KO mice and treated with FFA for 12 h. (D) Oil Red O staining and quantification of LD area (Original magnification x40, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (E) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, ***p < 0.001, Two- way ANOVA. (F) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (GeI) sh-Scramble and sh-TMEM135 cells were treated with FFA for 12 h. (G) Oil Red O staining and quantification of LD area (Original magnification x100, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (H) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (I) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Figure 1: Depletion of TMEM135 decreases lipid accumulation in the liver of HFD mice and FFA-treated primary hepatocytes and AML12 cells. (AeC) WT and TMEM135KO mice were fed either NCD or HFD for 22 weeks (n ¼ 6 per group). (A) Oil Red O staining of liver tissue section (Original magnification x100). (B) Immunoblots and densitometry for PLIN2, FSP27, and b-actin from the liver tissue of mice. Data represent mean SD, **p < 0.01, *p < 0.05, Two-way ANOVA. (C) Hepatic TG levels. Data represent mean SD, **p < 0.01, Two-way ANOVA. (DeF) Primary hepatocytes were isolated from the livers of WT and TMEM135KO mice and treated with FFA for 12 h. (D) Oil Red O staining and quantification of LD area (Original magnification x40, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (E) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, ***p < 0.001, Two- way ANOVA. (F) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (GeI) sh-Scramble and sh-TMEM135 cells were treated with FFA for 12 h. (G) Oil Red O staining and quantification of LD area (Original magnification x100, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (H) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (I) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Journal: Molecular metabolism

Article Title: TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner.

doi: 10.1016/j.molmet.2024.102080

Figure Lengend Snippet: Figure 1: Depletion of TMEM135 decreases lipid accumulation in the liver of HFD mice and FFA-treated primary hepatocytes and AML12 cells. (AeC) WT and TMEM135KO mice were fed either NCD or HFD for 22 weeks (n ¼ 6 per group). (A) Oil Red O staining of liver tissue section (Original magnification x100). (B) Immunoblots and densitometry for PLIN2, FSP27, and b-actin from the liver tissue of mice. Data represent mean SD, **p < 0.01, *p < 0.05, Two-way ANOVA. (C) Hepatic TG levels. Data represent mean SD, **p < 0.01, Two-way ANOVA. (DeF) Primary hepatocytes were isolated from the livers of WT and TMEM135KO mice and treated with FFA for 12 h. (D) Oil Red O staining and quantification of LD area (Original magnification x40, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (E) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, ***p < 0.001, Two- way ANOVA. (F) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (GeI) sh-Scramble and sh-TMEM135 cells were treated with FFA for 12 h. (G) Oil Red O staining and quantification of LD area (Original magnification x100, scale bar 20 mm). More than 100 cells per group in each experiment were measured. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (H) Immunoblots and densitometry for PLIN2 and b-actin. Data represent mean SD, ****p < 0.0001, Two-way ANOVA. (I) Quantification of TG levels. Data represent mean SD, ****p < 0.0001, **p < 0.01, Two-way ANOVA. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: CD36 antibody (#NB400-144) and FSP27 (#NB100-430) were bought from Novus Biological (Minneapolis, MN, USA).

Techniques: Staining, Western Blot, Isolation