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fmoc-tic-oh amino acid  (Synthetech Inc)

 
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    Synthetech Inc fmoc-tic-oh amino acid
    Fmoc Tic Oh Amino Acid, supplied by Synthetech Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fmoc-tic/fmoc+d+4+trifluoromethylphenylalanine/pmc09366794-76-10-16
    Average 90 stars, based on 1 article reviews
    fmoc-tic-oh amino acid - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).
    Article Snippet: The EMH single tetrapeptide synthesis was performed using standard 9-fluorenylmethoxycarbonyl (Fmoc) methodology in a CEM Discover SPS microwave peptide synthesizer.64,65 The amino acids Fmoc-His(trt), Fmoc-DPhe, Fmoc-Arg(Pbf), Fmoc-Trp(Boc), FmocTyr(tBu), Fmoc-DArg(Pbf), Fmoc-Tic (Synthetech), Fmoc-DTic (Synthetech), Fmoc-(pCl)DPhe, Fmoc-(pI)DPhe (Synthetech), Fmoc-(3I)-Tyr(tBu) (Anaspec), Fmoc-Lys(Boc), Fmoc-(pCl)Phe, Fmoc-(pNO2)DPhe, and Fmoc-Nal(1′) were purchased from Peptides International (Louisville, KY, USA) unless specified.

    Article Title: Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
    Article Snippet: The EMH single tetrapeptide synthesis was performed using standard 9-fluorenylmethoxycarbonyl (Fmoc) methodology in a CEM Discover SPS microwave peptide synthesizer., The amino acids Fmoc-His(trt), Fmoc-DPhe, Fmoc-Arg(Pbf), Fmoc-Trp(Boc), Fmoc-Tyr(tBu), Fmoc-DArg(Pbf), Fmoc-Tic (Synthetech), Fmoc-DTic (Synthetech), Fmoc-(pCl)DPhe, Fmoc-(pI)DPhe (Synthetech), Fmoc-(3I)-Tyr(tBu) (Anaspec), Fmoc-Lys(Boc), Fmoc-(pCl)Phe, Fmoc-(pNO 2 )DPhe, and Fmoc-Nal(1′) were purchased from Peptides International (Louisville, KY, USA) unless specified.

    Article Title: Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
    Article Snippet: The EMH single tetrapeptide synthesis was performed using standard 9-fluorenylmethoxycarbonyl (Fmoc) methodology in a CEM Discover SPS microwave peptide synthesizer.64,65 The amino acids Fmoc-His(trt), Fmoc-DPhe, Fmoc-Arg(Pbf), Fmoc-Trp(Boc), FmocTyr(tBu), Fmoc-DArg(Pbf), Fmoc-Tic (Synthetech), Fmoc-DTic (Synthetech), Fmoc-(pCl)DPhe, Fmoc-(pI)DPhe (Synthetech), Fmoc-(3I)-Tyr(tBu) (Anaspec), Fmoc-Lys(Boc), Fmoc-(pCl)Phe, Fmoc-(pNO2)DPhe, and Fmoc-Nal(1′) were purchased from Peptides International (Louisville, KY, USA) unless specified.



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    The diagram of the mechanism of compound’1966 under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.

    Journal: bioRxiv

    Article Title: AlphaFold3 and RoseTTAFold All-Atom structures enable radiosensitizers discovery by targeting multiple DNA damage repair proteins

    doi: 10.1101/2025.03.26.645385

    Figure Lengend Snippet: The diagram of the mechanism of compound’1966 under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.

    Article Snippet: According to the vendor list on the ZINC20, the compound’1966, Fmoc-Tic-OH (ZINC ID:621966, purity≥ 97%, F117108) was purchased from Aladdin Scientific (Shanghai, China).

    Techniques: Irradiation, Control