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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of <t>compound’1966</t> under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.
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The diagram of the mechanism of compound’1966 under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.

Journal: bioRxiv

Article Title: AlphaFold3 and RoseTTAFold All-Atom structures enable radiosensitizers discovery by targeting multiple DNA damage repair proteins

doi: 10.1101/2025.03.26.645385

Figure Lengend Snippet: The diagram of the mechanism of compound’1966 under irradiated and non-irradiated conditions. Interactions of these pathways were identified by EnrichmentMap plugin in Cytoscape. Five pathways were focused on DNA damage response, DNA damage repair, Cell cycle checkpoints, Cell apoptosis and cellular senescence. DEPs were categorized into these pathways and annotated based on log2FC values. On the left panel, DEPs between ZINC1966 and Control were annotated. On the right panel, DEPs between ZINC1966IR and IR were annotated.

Article Snippet: According to the vendor list on the ZINC20, the compound’1966, Fmoc-Tic-OH (ZINC ID:621966, purity≥ 97%, F117108) was purchased from Aladdin Scientific (Shanghai, China).

Techniques: Irradiation, Control