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eef1ε1  (Proteintech)


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    Structured Review

    Proteintech eef1ε1
    Existing studies frame rocaglates as pure eIF4A/translation inhibitors. This study conceptually redefines rocaglates as translation remodelers that reprogram both the translation machinery, e.g., increasing <t>eEF1ε1</t> translational activity, as well as the translatome, including the upregulation of numerous proteins, e.g., GEF-H1, that mediate rocaglate cytotoxicity in cancer cells. As a proof of concept, GEF-H1 activates RHOA, leading to increased JNK phosphorylation and apoptotic signaling resulting in reduced cell viability.
    Eef1ε1, supplied by Proteintech, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/eef1ε1/product/Proteintech
    Average 92 stars, based on 6 article reviews
    eef1ε1 - by Bioz Stars, 2026-06
    92/100 stars

    Images

    1) Product Images from "Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome"

    Article Title: Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

    Journal: Cell reports

    doi: 10.1016/j.celrep.2021.109806

    Existing studies frame rocaglates as pure eIF4A/translation inhibitors. This study conceptually redefines rocaglates as translation remodelers that reprogram both the translation machinery, e.g., increasing eEF1ε1 translational activity, as well as the translatome, including the upregulation of numerous proteins, e.g., GEF-H1, that mediate rocaglate cytotoxicity in cancer cells. As a proof of concept, GEF-H1 activates RHOA, leading to increased JNK phosphorylation and apoptotic signaling resulting in reduced cell viability.
    Figure Legend Snippet: Existing studies frame rocaglates as pure eIF4A/translation inhibitors. This study conceptually redefines rocaglates as translation remodelers that reprogram both the translation machinery, e.g., increasing eEF1ε1 translational activity, as well as the translatome, including the upregulation of numerous proteins, e.g., GEF-H1, that mediate rocaglate cytotoxicity in cancer cells. As a proof of concept, GEF-H1 activates RHOA, leading to increased JNK phosphorylation and apoptotic signaling resulting in reduced cell viability.

    Techniques Used: Activity Assay, Phospho-proteomics

    KEY RESOURCES TABLE
    Figure Legend Snippet: KEY RESOURCES TABLE

    Techniques Used: Plasmid Preparation, Derivative Assay, Recombinant, Protease Inhibitor, cDNA Synthesis, SYBR Green Assay, Mass Spectrometry, Construct, Software



    Similar Products

    eef1ε1  (Proteintech)
    92
    Proteintech eef1ε1
    Existing studies frame rocaglates as pure eIF4A/translation inhibitors. This study conceptually redefines rocaglates as translation remodelers that reprogram both the translation machinery, e.g., increasing <t>eEF1ε1</t> translational activity, as well as the translatome, including the upregulation of numerous proteins, e.g., GEF-H1, that mediate rocaglate cytotoxicity in cancer cells. As a proof of concept, GEF-H1 activates RHOA, leading to increased JNK phosphorylation and apoptotic signaling resulting in reduced cell viability.
    Eef1ε1, supplied by Proteintech, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/eef1ε1/product/Proteintech
    Average 92 stars, based on 1 article reviews
    eef1ε1 - by Bioz Stars, 2026-06
    92/100 stars
    		  Buy from Supplier

    Image Search Results


    Existing studies frame rocaglates as pure eIF4A/translation inhibitors. This study conceptually redefines rocaglates as translation remodelers that reprogram both the translation machinery, e.g., increasing eEF1ε1 translational activity, as well as the translatome, including the upregulation of numerous proteins, e.g., GEF-H1, that mediate rocaglate cytotoxicity in cancer cells. As a proof of concept, GEF-H1 activates RHOA, leading to increased JNK phosphorylation and apoptotic signaling resulting in reduced cell viability.

    Journal: Cell reports

    Article Title: Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

    doi: 10.1016/j.celrep.2021.109806

    Figure Lengend Snippet: Existing studies frame rocaglates as pure eIF4A/translation inhibitors. This study conceptually redefines rocaglates as translation remodelers that reprogram both the translation machinery, e.g., increasing eEF1ε1 translational activity, as well as the translatome, including the upregulation of numerous proteins, e.g., GEF-H1, that mediate rocaglate cytotoxicity in cancer cells. As a proof of concept, GEF-H1 activates RHOA, leading to increased JNK phosphorylation and apoptotic signaling resulting in reduced cell viability.

    Article Snippet: eEF1ε1 , Proteintech , Cat#10805-1-AP; RRID:AB_2097140.

    Techniques: Activity Assay, Phospho-proteomics

    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

    doi: 10.1016/j.celrep.2021.109806

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: eEF1ε1 , Proteintech , Cat#10805-1-AP; RRID:AB_2097140.

    Techniques: Plasmid Preparation, Derivative Assay, Recombinant, Protease Inhibitor, cDNA Synthesis, SYBR Green Assay, Mass Spectrometry, Construct, Software