Journal: bioRxiv
Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages
doi: 10.64898/2026.01.21.700899
Figure Lengend Snippet: Donors from were combined with an independent archival cohort to assess correlations between dopamine receptor expression and epigenetic enzyme expression by qPCR. DRD1 expression was significantly correlated with ( A ) HDAC2 (n=28, **p<0.01), ( B ) HDAC6 (n=25, **p<0.01), ( C ) KAT2A (n=28, **p<0.01), and ( D ) KDM6B expression (n=28, ***p<0.001). DRD5 expression was significantly correlated with ( E ) HDAC2 (n=28, *p<0.01), ( F ) HDAC6 (n=25, *p<0.01), and ( H ) KDM6B (n=28, *p<0.05), but not with ( G ) KAT2A expression (n=28, p=0.0733).
Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.
Techniques: Expressing