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disopyramide  (MedChemExpress)


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    Structured Review

    MedChemExpress disopyramide
    Disopyramide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/disopyramide/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    disopyramide - by Bioz Stars, 2026-02
    94/100 stars

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    List of drugs and their concentrations used in the drug testing experiments.
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    Chemical structures and characterizations of drugs used in this study.
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    Millipore disopyramide phosphate
    Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, <t>disopyramide,</t> ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .
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    Millipore disopyramide
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    FUJIFILM disopyramide
    Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, <t>disopyramide,</t> ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .
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    Image Search Results


    List of drugs and their concentrations used in the drug testing experiments.

    Journal: Frontiers in Physiology

    Article Title: CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses

    doi: 10.3389/fphys.2024.1472126

    Figure Lengend Snippet: List of drugs and their concentrations used in the drug testing experiments.

    Article Snippet: Dimethyl sulfoxide (DMSO, Cat. D4540), quinidine (Cat. 22600), nifedipine (N7634), flecainide (Cat. F0120000), amiodarone (Cat. A8423), sotalol (Cat. S0278), and disopyramide (Cat. D2920000) were purchased from Merck KGaA (Darmstadt, Germany).

    Techniques: Concentration Assay

    Chemical structures and characterizations of drugs used in this study.

    Journal: Pharmaceutics

    Article Title: The Development and Characterization of Novel Ionic Liquids Based on Mono- and Dicarboxylates with Meglumine for Drug Solubilizers and Skin Permeation Enhancers

    doi: 10.3390/pharmaceutics16030322

    Figure Lengend Snippet: Chemical structures and characterizations of drugs used in this study.

    Article Snippet: TA, Captopril (CPP), and Disopyramide (DPA) were obtained from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan).

    Techniques:

    Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, disopyramide, ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .

    Journal: Cardiovascular Research

    Article Title: Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs

    doi: 10.1093/cvr/cvad141

    Figure Lengend Snippet: Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, disopyramide, ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .

    Article Snippet: Drugs from the CiPA list were added at five different concentration steps into 3–4 mL from the following stocks: bepridil hydrochloride (Tocris Bioscience, UK) 10 mM dissolved in DMSO; ibutilide hemifumarate (Sigma-Aldrich, USA) 10 μM dissolved in H 2 O; disopyramide phosphate (Sigma-Aldrich, USA) 10 mM dissolved in H 2 O; cisapride monohydrate 100 μM dissolved in DMSO; risperidone (Sigma-Aldrich, USA) 1 mM dissolved in DMSO; and acetylsalicylic acid (Sigma-Aldrich, USA) 100 μM dissolved in H 2 O.

    Techniques: Comparison, Solvent