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daucosterol  (MedChemExpress)


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    Structured Review

    MedChemExpress daucosterol
    Virtual verification of Huaier targets by molecular docking. (a) Maestro 2D interactions between EGFR and gefitinib, adenosine, <t>daucosterol,</t> ergosterol, ergosta-7,22-dien-3β-ol and 3β-hydroxystigmast-5,22-dien-7-one. Residues in green spheres are hydrophobic, blue spheres are polar, red spheres are negatively charged, purple spheres are charged and light yellow spheres are glycine. The purple arrows and their directions represent hydrogen bonds between the ligand and the protein. The green line represents the π-π stacking arrangement seen between the aromatic core. (b) We conducted kinase activity assays to validate Huaier ’s inhibition on EGFR kinase activity. Staurosporine, an effective PKC inhibitor, was chosen as positive control. (c) Cells were conducted by CETSAs, and the protein expression of EGFR was detected by western blot analysis. The line chart showed the relative expression level of EGFR.
    Daucosterol, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/daucosterol/product/MedChemExpress
    Average 90 stars, based on 8 article reviews
    daucosterol - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "An extraction from Trametes robiniophila Murr. ( Huaier ) inhibits non-small cell lung cancer proliferation via targeting to epidermal growth factor receptor"

    Article Title: An extraction from Trametes robiniophila Murr. ( Huaier ) inhibits non-small cell lung cancer proliferation via targeting to epidermal growth factor receptor

    Journal: Bioengineered

    doi: 10.1080/21655979.2022.2066757

    Virtual verification of Huaier targets by molecular docking. (a) Maestro 2D interactions between EGFR and gefitinib, adenosine, daucosterol, ergosterol, ergosta-7,22-dien-3β-ol and 3β-hydroxystigmast-5,22-dien-7-one. Residues in green spheres are hydrophobic, blue spheres are polar, red spheres are negatively charged, purple spheres are charged and light yellow spheres are glycine. The purple arrows and their directions represent hydrogen bonds between the ligand and the protein. The green line represents the π-π stacking arrangement seen between the aromatic core. (b) We conducted kinase activity assays to validate Huaier ’s inhibition on EGFR kinase activity. Staurosporine, an effective PKC inhibitor, was chosen as positive control. (c) Cells were conducted by CETSAs, and the protein expression of EGFR was detected by western blot analysis. The line chart showed the relative expression level of EGFR.
    Figure Legend Snippet: Virtual verification of Huaier targets by molecular docking. (a) Maestro 2D interactions between EGFR and gefitinib, adenosine, daucosterol, ergosterol, ergosta-7,22-dien-3β-ol and 3β-hydroxystigmast-5,22-dien-7-one. Residues in green spheres are hydrophobic, blue spheres are polar, red spheres are negatively charged, purple spheres are charged and light yellow spheres are glycine. The purple arrows and their directions represent hydrogen bonds between the ligand and the protein. The green line represents the π-π stacking arrangement seen between the aromatic core. (b) We conducted kinase activity assays to validate Huaier ’s inhibition on EGFR kinase activity. Staurosporine, an effective PKC inhibitor, was chosen as positive control. (c) Cells were conducted by CETSAs, and the protein expression of EGFR was detected by western blot analysis. The line chart showed the relative expression level of EGFR.

    Techniques Used: Activity Assay, Inhibition, Positive Control, Expressing, Western Blot



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    Image Search Results


    Virtual verification of Huaier targets by molecular docking. (a) Maestro 2D interactions between EGFR and gefitinib, adenosine, daucosterol, ergosterol, ergosta-7,22-dien-3β-ol and 3β-hydroxystigmast-5,22-dien-7-one. Residues in green spheres are hydrophobic, blue spheres are polar, red spheres are negatively charged, purple spheres are charged and light yellow spheres are glycine. The purple arrows and their directions represent hydrogen bonds between the ligand and the protein. The green line represents the π-π stacking arrangement seen between the aromatic core. (b) We conducted kinase activity assays to validate Huaier ’s inhibition on EGFR kinase activity. Staurosporine, an effective PKC inhibitor, was chosen as positive control. (c) Cells were conducted by CETSAs, and the protein expression of EGFR was detected by western blot analysis. The line chart showed the relative expression level of EGFR.

    Journal: Bioengineered

    Article Title: An extraction from Trametes robiniophila Murr. ( Huaier ) inhibits non-small cell lung cancer proliferation via targeting to epidermal growth factor receptor

    doi: 10.1080/21655979.2022.2066757

    Figure Lengend Snippet: Virtual verification of Huaier targets by molecular docking. (a) Maestro 2D interactions between EGFR and gefitinib, adenosine, daucosterol, ergosterol, ergosta-7,22-dien-3β-ol and 3β-hydroxystigmast-5,22-dien-7-one. Residues in green spheres are hydrophobic, blue spheres are polar, red spheres are negatively charged, purple spheres are charged and light yellow spheres are glycine. The purple arrows and their directions represent hydrogen bonds between the ligand and the protein. The green line represents the π-π stacking arrangement seen between the aromatic core. (b) We conducted kinase activity assays to validate Huaier ’s inhibition on EGFR kinase activity. Staurosporine, an effective PKC inhibitor, was chosen as positive control. (c) Cells were conducted by CETSAs, and the protein expression of EGFR was detected by western blot analysis. The line chart showed the relative expression level of EGFR.

    Article Snippet: Gefitinib and Daucosterol were both purchased from MCE (HY-50895; HY-N0410).

    Techniques: Activity Assay, Inhibition, Positive Control, Expressing, Western Blot

    Structural details of tested glycosides Substitution pattern is derived from <xref ref-type= Fig. 1C . Maximum response was defined at 1 mM ATP. To calculate the EC 50 ratio, the average EC 50 value for ATP + vehicle was used from each set of experiments. Average EC 50 value is shown with 95% confidence intervals in parentheses." width="100%" height="100%">

    Journal: Molecular Pharmacology

    Article Title: Insights into the Structure-Activity Relationship of Glycosides as Positive Allosteric Modulators Acting on P2X7 Receptors

    doi: 10.1124/molpharm.120.000129

    Figure Lengend Snippet: Structural details of tested glycosides Substitution pattern is derived from Fig. 1C . Maximum response was defined at 1 mM ATP. To calculate the EC 50 ratio, the average EC 50 value for ATP + vehicle was used from each set of experiments. Average EC 50 value is shown with 95% confidence intervals in parentheses.

    Article Snippet: Ginsenoside-CK (CAS 39262-14-1), ginsenoside-Rb1 (CAS 41753-43-9), ginsenoside-Rd (CAS 52705-93-8), 20( S )-ginsenoside-Rg3 (CAS 14197-60-5), 20( R )-ginsenoside-Rh2 (CAS 112246-15-8), protopanaxadiol (PPD) (CAS 30636-90-9), glycyrrhizic acid (CAS 1405-86-3), stevioside (CAS 57817-89-7), daucosterol (CAS 474-58-8), esculentoside A (CAS 65497-07-6), mogroside V (CAS 88901-36-4), saikosaponin A (CAS 20736-09-8), and stevenleaf (CAS 80321-63-7) were from Shanghai Richem International Ltd., China (supplier code CDCMANSETE).

    Techniques: Derivative Assay

    Screening glycosides containing monosaccharide moieties at P2X7. Dose-response curves to ATP in the presence of vehicle (DMSO), ginsenoside-CK, and the following: daucosterol (10 µM) (A), stevioside (SV; 10 µM) (B), ginsenoside-F1 (F1; 10 µM) (C), ginsenoside-F2 (F2; 10 µM) (D), ouabain (10 µM) (E), or scilliroside (10 µM) (F). Ginsenoside-CK is demonstrated throughout as the reference compound (same data shown in each plot). Data are collated from three independent experiments each performed in triplicate. Error bars represent S.D.

    Journal: Molecular Pharmacology

    Article Title: Insights into the Structure-Activity Relationship of Glycosides as Positive Allosteric Modulators Acting on P2X7 Receptors

    doi: 10.1124/molpharm.120.000129

    Figure Lengend Snippet: Screening glycosides containing monosaccharide moieties at P2X7. Dose-response curves to ATP in the presence of vehicle (DMSO), ginsenoside-CK, and the following: daucosterol (10 µM) (A), stevioside (SV; 10 µM) (B), ginsenoside-F1 (F1; 10 µM) (C), ginsenoside-F2 (F2; 10 µM) (D), ouabain (10 µM) (E), or scilliroside (10 µM) (F). Ginsenoside-CK is demonstrated throughout as the reference compound (same data shown in each plot). Data are collated from three independent experiments each performed in triplicate. Error bars represent S.D.

    Article Snippet: Ginsenoside-CK (CAS 39262-14-1), ginsenoside-Rb1 (CAS 41753-43-9), ginsenoside-Rd (CAS 52705-93-8), 20( S )-ginsenoside-Rg3 (CAS 14197-60-5), 20( R )-ginsenoside-Rh2 (CAS 112246-15-8), protopanaxadiol (PPD) (CAS 30636-90-9), glycyrrhizic acid (CAS 1405-86-3), stevioside (CAS 57817-89-7), daucosterol (CAS 474-58-8), esculentoside A (CAS 65497-07-6), mogroside V (CAS 88901-36-4), saikosaponin A (CAS 20736-09-8), and stevenleaf (CAS 80321-63-7) were from Shanghai Richem International Ltd., China (supplier code CDCMANSETE).

    Techniques:

    Top 10 molecular docking terms identified by AutoDock Vina.

    Journal: BioMed Research International

    Article Title: Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach

    doi: 10.1155/2020/8887982

    Figure Lengend Snippet: Top 10 molecular docking terms identified by AutoDock Vina.

    Article Snippet: Berberine (CAS: 2086-83-1), quercetin (CAS: 117-39-5), and daucosterol (CAS: 474-58-8) were purchased from Solarbio (Beijing, China), and ginkgetin (CAS: 481-46-9) and isoginkgetin (CAS: 548-19-6) were purchased from MedChemExpress (Shanghai, China).

    Techniques: Protein Binding

    Affinity test between component and tumor target using surface plasmon resonance (SPR) assay.

    Journal: BioMed Research International

    Article Title: Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach

    doi: 10.1155/2020/8887982

    Figure Lengend Snippet: Affinity test between component and tumor target using surface plasmon resonance (SPR) assay.

    Article Snippet: Berberine (CAS: 2086-83-1), quercetin (CAS: 117-39-5), and daucosterol (CAS: 474-58-8) were purchased from Solarbio (Beijing, China), and ginkgetin (CAS: 481-46-9) and isoginkgetin (CAS: 548-19-6) were purchased from MedChemExpress (Shanghai, China).

    Techniques: SPR Assay, Concentration Assay

    Relative response value of affinity test between (a) AKT1 and berberine, (b) TP53 and berberine, (c) EGFR and quercetin, (d) VEGF165 and ginkgetin, (e) VEGF165 and isoginkgetin, (f) VEGF165 and daucosterol, and (g) VEGF165 and quercetin by surface plasmon resonance assay.

    Journal: BioMed Research International

    Article Title: Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach

    doi: 10.1155/2020/8887982

    Figure Lengend Snippet: Relative response value of affinity test between (a) AKT1 and berberine, (b) TP53 and berberine, (c) EGFR and quercetin, (d) VEGF165 and ginkgetin, (e) VEGF165 and isoginkgetin, (f) VEGF165 and daucosterol, and (g) VEGF165 and quercetin by surface plasmon resonance assay.

    Article Snippet: Berberine (CAS: 2086-83-1), quercetin (CAS: 117-39-5), and daucosterol (CAS: 474-58-8) were purchased from Solarbio (Beijing, China), and ginkgetin (CAS: 481-46-9) and isoginkgetin (CAS: 548-19-6) were purchased from MedChemExpress (Shanghai, China).

    Techniques: SPR Assay