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dasatinib  (MedChemExpress)


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    MedChemExpress dasatinib
    YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, <t>Dasatinib,</t> and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
    Dasatinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 17 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dasatinib/pmc13123377-73-11-14?v=MedChemExpress
    Average 94 stars, based on 17 article reviews
    dasatinib - by Bioz Stars, 2026-07
    94/100 stars

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    1) Product Images from "Mechanical cues regulate in vitro implantation of mouse embryos"

    Article Title: Mechanical cues regulate in vitro implantation of mouse embryos

    Journal: Materials Today Bio

    doi: 10.1016/j.mtbio.2026.103105

    YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, Dasatinib, and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
    Figure Legend Snippet: YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, Dasatinib, and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Techniques Used: In Vitro, Cell Culture, Control, Expressing, Marker, RNA Sequencing, Gene Expression, Two Tailed Test



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    YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, <t>Dasatinib,</t> and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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    YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, <t>Dasatinib,</t> and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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    Image Search Results


    YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, Dasatinib, and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Journal: Materials Today Bio

    Article Title: Mechanical cues regulate in vitro implantation of mouse embryos

    doi: 10.1016/j.mtbio.2026.103105

    Figure Lengend Snippet: YAP dysregulation impacts preimplantation embryogenesis in vitro . (a ) Representative images showing YAP subcellular localization in embryos cultured on substrates with different stiffness levels on IVC day 2. The DMSO treated group served as the control, while the experimental groups included treatment with Leptomycin B, Dasatinib, and Verteporfin. (b) Quantification of the nuclear/cytosolic YAP ratio. n = 25, 22, 22, and 22 for 1 kPa, 4 kPa, 10 kPa, and 50 kPa, respectively. (c) Percentage of cavitated embryos following treatment with YAP-related inhibitors on IVC day 3 (n = 45). (d – e) Scaled expression heatmap of YAP signaling and embryonic implantation marker genes, based on hierarchical clustering of RNA-seq data. The x-axis represents sample names. The y-axis represents the FPKM-normalized values of differentially expressed genes. Red intensity indicates higher expression levels, while blue intensity indicates lower expression levels. (f) GO enrichment analysis of Leptomycin B-treated embryos versus controls (DMSO). Bubble chart displays the significant GO terms selected from the enrichment results. The x-axis represents the gene ratio, and the y-axis represents GO terms. GO terms with padj <0.05 were considered significantly enriched. (g) GO enrichment analysis of Verteporfin-treated embryos versus controls (DMSO). (h) Volcano plot displaying differential gene expression following Leptomycin B treatment versus control embryos. Data points are plotted according to log 2 FoldChange on the x-axis and -log 10 (padj) on the y-axis. Gray dashed lines indicate significance thresholds; red points represent upregulated genes and blue points represent downregulated genes. (i) Volcano plot displaying differential gene expression following Verteporfin treatment versus control embryos. Statistical analysis was performed using a two-tailed Student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Article Snippet: YAP inhibitors—Leptomycin B (100 ng/mL, Selleck), Verteporfin (1 μM, Sigma), and Dasatinib (10 μM, MedChemExpress)—were added at 36 h of embryonic culture and maintained for 12 h before proceeding to the next experimental step.

    Techniques: In Vitro, Cell Culture, Control, Expressing, Marker, RNA Sequencing, Gene Expression, Two Tailed Test