Journal: The FASEB Journal
Article Title: An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells
doi: 10.1096/fj.201700663R
Figure Lengend Snippet: Positive hits and their corresponding primary targets
Article Snippet: Note that some hits are expected ( e.g. , nocodazole), whereas most hits are novel and unexpected, including simvastatin and mevastatin. table ft1 table-wrap mode="anchored" t5 TABLE 1. caption a7 Label Compound Primary target (compound activity) Known functions of primary target A (±)-Palmitoylcarinitine chloride PKC (inhibitor); membrane disruption Context-dependent cell signaling functions B Cantharidin PP1 and PP2A (inhibitor) Context-dependent cell signaling functions C CGP 52411 EGFR (inhibitor) Receptor tyrosine kinase regulating multiple signaling cascades D m -3M3FBS PLC (activator) Numerous cell signaling functions, including cytoskeletal dynamics E Nocodazole Microtubule depolymerizer (inhibitor) Cell division, movement, transport F D-64131 Microtubule depolymerizer (inhibitor) Cell division, movement, transport G KF 38789 P-selectin mediated adhesion (inhibitor) Cell adhesion molecule of endothelial cells and platelets H Diphenylene-iodonium chloride GPR3 (agonist) Orphan GPCR involved in aging, metabolism, and thermogenesis I LY 2183240 FAAH and anandamide uptake (inhibitor) Endocannabinoid signaling J Carvedilol β-Adrenergic receptor (antagonist) GPCR targeted by catecholamines K SB 225002 CXCR2 chemokine receptor (antagonist) GPCR targeted by IL-8 and CXCL1 L Ch 55 RAR (agonist) Regulation of gene expression M INCA-6 Calcineurin-NFAT interaction (inhibitor) Gene regulation in response to environmental signals N JK 184 Hedgehog signaling (inhibitor) Cell survival, differentiation, cancer O Ivermectin α7-Nicotinic receptor (activator) Ligand-gated calcium ion channel P PNU 74654 β-Catenin-TCF4 interaction (inhibitor) Transcriptional regulation of cell adhesion and epithelial-mesenchymal transition Q Simvastatin HMG-CoA reductase (inhibitor) Cholesterol and nonsterol isoprenoid biosynthesis R Mevastatin HMG-CoA reductase (inhibitor) Cholesterol and nonsterol isoprenoid biosynthesis Open in a separate window CXCL1, C-X-C motif chemokine 1; CXCR2, C-X-C chemokine receptor type 2; EGFR, epidermal growth factor receptor; FAAH, fatty acid amide hydrolase; GPR3, G-protein coupled receptor 3; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; NFAT, nuclear factor of activated T cells; RAR, retinoic acid receptor; TCF4, transcription factor 4.
Techniques: Activity Assay, Expressing
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