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Proteintech cyp7b1
Cyp7b1, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 48 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cyp7b1/CYP7B1+Antibody/10__1016_slash_j__jff__2026__107194-73-33-34
Average 95 stars, based on 48 article reviews

cyp7b1 - by Bioz Stars, 2026-10

95/100 stars

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Article Title: 20(S/R)-ginsenoside Rh1 improves type 2 diabetes via gut microbiota-modulated bile acid signaling and FXR/TGR5-dependent GLP-1 enhancement.
Article Snippet: The membranes were blocked with 5 % BSA at room temperature for 1 h. Ileal protein samples were incubated at 4 °C overnight with the following antibodies: β-actin, TGR5, FXR, CREB, phospho-JNK, c-FLIP, GCG, PCSK1 (Proteintech, Wuhan, China) and JNK (Abcam, Cambridge, UK). .. Liver protein samples were incubated with antibodies: β-actin, CYP7A1, CYP27A1, and CYP7B1 (Proteintech, Wuhan, China). ..

Article Title: Ablation of ACSS2 drives alteration to cardiac and hepatic proteomic landscapes in a tissue- and sex-specific manner.
Article Snippet: ACSS2 catalyzes the conversion of acetate into acetyl-CoA, linking nutrient availability to cellular processes such as lipid biosynthesis, energy production, and epigenetic regulation.. Although ACSS2 has been studied under metabolically stressful conditions, its basal sexand tissue-specific functions remain poorly defined.. Here, we employed comprehensive proteomic characterization of the impact of global ACSS2 ablation in the liver and heart of adult male and female mice.

Staining:

Blocking Assay:

Western Blot:

Article Title: L. acidophilus prevents cholesterol gallstones in mice by regulating gut microbiota-mediated BAs metabolism and cholesterol homeostasis
Article Snippet: The phospholipid level assay kit was provided by Wako Pure Chemical Industries, Ltd., Osaka, Japan. .. Western blot analysis The purchased antibodies and their catalog numbers are as follows: FXR (Cell Signaling, 12295, 1:1000), FGF15 (Abcam, ab229630, 1:1000), FGFR4 (Proteintech, 11098–1-AP), CYP7A1 (Abcam, ab65596, 1:1000), CYP8B1 (Proteintech, 55217–1-AP, 1:1000), CYP7B1 (Proteintech, 24889–1-AP, 1:1000), CYP27A1 (Proteintech, 14739–1-AP, 1:1000), ZO-1(Abmart, TA5145S, 1:1000), Claudin (Abmart, TA0127S, 1:1000), Occludin (T55997S, 1:1000), HMGCR (Proteintech, 13533–1-AP, 1:1000), SREBP2 (Abmart, TD7601S, 1:1000), ABCG5 (Proteintech, 27722-1-AP, 1:1000), ABCG8 (Proteintech, 24453-1-AP, 1:1000). ..

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CH25H and CYP7B1 expression was downregulated by dexamethasone in primary chondrocytes from wild-type (WT) mice, and the effect was attenuated in chondrocytes from MKP-1 deficient (knockout, KO) mice. Murine chondrocytes were stimulated with IL-1β (100 pg/mL), either alone or in combination with dexamethasone (1 μM), for 24 h. CH25H ( A ) and CYP7B1 ( B ) mRNA was measured by RT-PCR and normalized to GAPDH. For each genotype, IL-1β-treated samples were set as 100%, and the other values are presented in relation to those values. Data are shown as mean + SEM (n = 8). Statistical analysis was carried out with two-way ANOVA followed by Bonferroni post-test; ** p < 0.01, *** p < 0.0001

Journal: Inflammation Research

Article Title: Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1

doi: 10.1007/s00011-025-02121-5

Figure Lengend Snippet: CH25H and CYP7B1 expression was downregulated by dexamethasone in primary chondrocytes from wild-type (WT) mice, and the effect was attenuated in chondrocytes from MKP-1 deficient (knockout, KO) mice. Murine chondrocytes were stimulated with IL-1β (100 pg/mL), either alone or in combination with dexamethasone (1 μM), for 24 h. CH25H ( A ) and CYP7B1 ( B ) mRNA was measured by RT-PCR and normalized to GAPDH. For each genotype, IL-1β-treated samples were set as 100%, and the other values are presented in relation to those values. Data are shown as mean + SEM (n = 8). Statistical analysis was carried out with two-way ANOVA followed by Bonferroni post-test; ** p < 0.01, *** p < 0.0001

Article Snippet: Mouse CH25H (Mm00515486_s1), mouse CYP7B1 (Mm00484157_m1), human CH25H (Hs02379634_s1) and human CYP7B1 (Hs01046431_m1) were detected using TaqMan® Gene Expression assays obtained from Thermo Fisher Scientific.

Techniques: Expressing, Knock-Out, Reverse Transcription Polymerase Chain Reaction

CH25H and CYP7B1 expressions were suppressed by dexamethasone in primary human OA chondrocytes. Chondrocytes were treated with interleukin-1β (IL-1β, 100 pg/mL), either alone or in combination with dexamethasone (1 μM), for 24 h. CH25H ( A ) and CYP7B1 ( B ) mRNA was measured by RT-PCR and normalized to GAPDH. Expression in the IL-1β-treated samples was set as 100%, and the other values are presented in relation to that value. Data are shown as mean + SEM (n = 5). Statistical analysis was carried out with repeated measures ANOVA followed by Bonferroni post-test; **** p < 0.0001

Journal: Inflammation Research

Article Title: Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1

doi: 10.1007/s00011-025-02121-5

Figure Lengend Snippet: CH25H and CYP7B1 expressions were suppressed by dexamethasone in primary human OA chondrocytes. Chondrocytes were treated with interleukin-1β (IL-1β, 100 pg/mL), either alone or in combination with dexamethasone (1 μM), for 24 h. CH25H ( A ) and CYP7B1 ( B ) mRNA was measured by RT-PCR and normalized to GAPDH. Expression in the IL-1β-treated samples was set as 100%, and the other values are presented in relation to that value. Data are shown as mean + SEM (n = 5). Statistical analysis was carried out with repeated measures ANOVA followed by Bonferroni post-test; **** p < 0.0001

Techniques: Reverse Transcription Polymerase Chain Reaction, Expressing

CH25H and CYP7B1 expressions were differently regulated by MAP kinase inhibitors. The primary human OA chondrocytes were treated with IL-1β (100 pg/mL) alone or in combination with the p38 MAP kinase inhibitor BIRB796 (100 nM) or with the JNK MAP kinase inhibitor SP600125 (10 μM) for 24 h. CH25H and CYP7B1 mRNA was measured by RT-PCR and normalized to GAPDH. CH25H ( A ) and CYP7B1 ( B ) expression levels in IL-1β -treated samples were set as 100%, and the other values are given in relation to those values. Data are shown as mean + SEM, n = 6. Statistical analysis was carried out with repeated measures ANOVA followed by Bonferroni post-test; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

Journal: Inflammation Research

Article Title: Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1

doi: 10.1007/s00011-025-02121-5

Figure Lengend Snippet: CH25H and CYP7B1 expressions were differently regulated by MAP kinase inhibitors. The primary human OA chondrocytes were treated with IL-1β (100 pg/mL) alone or in combination with the p38 MAP kinase inhibitor BIRB796 (100 nM) or with the JNK MAP kinase inhibitor SP600125 (10 μM) for 24 h. CH25H and CYP7B1 mRNA was measured by RT-PCR and normalized to GAPDH. CH25H ( A ) and CYP7B1 ( B ) expression levels in IL-1β -treated samples were set as 100%, and the other values are given in relation to those values. Data are shown as mean + SEM, n = 6. Statistical analysis was carried out with repeated measures ANOVA followed by Bonferroni post-test; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

Techniques: Reverse Transcription Polymerase Chain Reaction, Expressing

Tgr5 mRNA (A) expression in liver of myeloid-specific Fmr1 deficient (Fmr1 fl -LysM cre ) compared to control (Fmr1 fl ), N = 5 each. Representative Western blot (B) of Tgr5 from liver extract of Fmr1 fl -LysM cre and Fmr1 fl mice with quantification below, N = 4-5 each. IL-1β (C) and IL-6 (D) mRNA expression in livers (N = 4-5 each). (A-D) *P < 0.05 ANOVA with multiple comparison test. BMDM Tgr5 mRNA expression in male; N = 4-5 each (E) and Western blot with quantification below (F) in both female (N = 2 each) and male (N = 2-3) Fmr1 fl compared to Fmr1 fl -LysM cre ; **P < 0.01 T test. Gating scheme (G) for Tgr5 staining and FACS analysis of peritoneal macrophage double positive for F4/80 and CD11b. Percentage of Tgr5 + peritoneal macrophage (H) of Fmr1 fl (N = 8; 4 each sex) compared to Fmr1 fl -LysM cre (N = 6; 3 each sex) mice. *P < 0.05 T test.

Journal: PLOS One

Article Title: Myeloid Fmr1 deficiency in mice results in reduced serum cholesterol and altered bile pathway gene expression

doi: 10.1371/journal.pone.0340222

Figure Lengend Snippet: Tgr5 mRNA (A) expression in liver of myeloid-specific Fmr1 deficient (Fmr1 fl -LysM cre ) compared to control (Fmr1 fl ), N = 5 each. Representative Western blot (B) of Tgr5 from liver extract of Fmr1 fl -LysM cre and Fmr1 fl mice with quantification below, N = 4-5 each. IL-1β (C) and IL-6 (D) mRNA expression in livers (N = 4-5 each). (A-D) *P < 0.05 ANOVA with multiple comparison test. BMDM Tgr5 mRNA expression in male; N = 4-5 each (E) and Western blot with quantification below (F) in both female (N = 2 each) and male (N = 2-3) Fmr1 fl compared to Fmr1 fl -LysM cre ; **P < 0.01 T test. Gating scheme (G) for Tgr5 staining and FACS analysis of peritoneal macrophage double positive for F4/80 and CD11b. Percentage of Tgr5 + peritoneal macrophage (H) of Fmr1 fl (N = 8; 4 each sex) compared to Fmr1 fl -LysM cre (N = 6; 3 each sex) mice. *P < 0.05 T test.

Article Snippet: Primary antibodies used were: LDLR (Invitrogen), Cyp7b1 (Proteintech), Cyp27a1 (Abcam) and Tgr5 (Proteintech).

Techniques: Expressing, Control, Western Blot, Comparison, Staining

Triglyceride secretion rate and analyses of secreted lipoproteins following tyloxapol administration in rats . ( A ) Rate of plasma triglyceride concentration measured after a 16 h fast followed by intraperitoneal injection of tyloxapol (700 mg per kg body weight) in male wild-type and homozygous Cyp7b1 -deficient rats (n = 11 per group). * p < 0.05 according to Mann–Whitney’s U-test. FPLC separation of plasma lipoproteins from both groups of rats four hours after tyloxapol injection and their APOB contents are reflected in panel ( C ). Their triglyceride and cholesterol contents are depicted in ( B , D ), respectively. Open squares correspond to wild-type and black triangles to Cyp7b1 -deficient rats.

Journal: International Journal of Molecular Sciences

Article Title: The Disruption of Cyp7b1 Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites

doi: 10.3390/ijms262411994

Figure Lengend Snippet: Triglyceride secretion rate and analyses of secreted lipoproteins following tyloxapol administration in rats . ( A ) Rate of plasma triglyceride concentration measured after a 16 h fast followed by intraperitoneal injection of tyloxapol (700 mg per kg body weight) in male wild-type and homozygous Cyp7b1 -deficient rats (n = 11 per group). * p < 0.05 according to Mann–Whitney’s U-test. FPLC separation of plasma lipoproteins from both groups of rats four hours after tyloxapol injection and their APOB contents are reflected in panel ( C ). Their triglyceride and cholesterol contents are depicted in ( B , D ), respectively. Open squares correspond to wild-type and black triangles to Cyp7b1 -deficient rats.

Article Snippet: Then, the medium was withdrawn, and the cells were washed twice with PBS before being transfected with CYP7B1 HDR and CYP7B1 CRISPR/Cas9 KO plasmids (Santa Cruz Biotechnology) using lipofectamine 2000 (Thermo Fisher Scientific).

Techniques: Clinical Proteomics, Concentration Assay, Injection

Hepatic analyses of rats after 16 h of fasting. ( A ) Representative Western blot analysis of plasma membrane proteins related to lipoprotein metabolism. Hepatic plasma membrane contents of ( B ) low-density lipoprotein receptor (LDLR); ( C ) ATP-binding cassette subfamily A member 1 (ABCA1); ( D ) low-density lipoprotein receptor-related protein 1 (LRP1); and ( E ) syndecan 1 (SDC1). Results of Western blot analyses were normalized to the data of flotillin 2 (FLOT2) as loading control. ( F ) Ldlr mRNA and ( G ) Pcsk9 mRNA expressions. Values are reported as relative arbitrary unit (AU) levels obtained by RT-qPCR and normalized to Rn18s. ( H ) Hepatic levels of 25-hydroxycholesterol. ( I ) Morphometric changes in lipid droplet area expressed as a percentage of the total liver section. Data are shown as means ± SD with their individual values of 4 WT and 6 homozygous Cyp7b1 -deficient (KO) rats. Statistical analysis was performed using the Mann–Whitney U-test. * p < 0.05, ** p < 0.02, *** p < 0.01, and **** p < 0.001 vs. control.

Journal: International Journal of Molecular Sciences

Article Title: The Disruption of Cyp7b1 Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites

doi: 10.3390/ijms262411994

Figure Lengend Snippet: Hepatic analyses of rats after 16 h of fasting. ( A ) Representative Western blot analysis of plasma membrane proteins related to lipoprotein metabolism. Hepatic plasma membrane contents of ( B ) low-density lipoprotein receptor (LDLR); ( C ) ATP-binding cassette subfamily A member 1 (ABCA1); ( D ) low-density lipoprotein receptor-related protein 1 (LRP1); and ( E ) syndecan 1 (SDC1). Results of Western blot analyses were normalized to the data of flotillin 2 (FLOT2) as loading control. ( F ) Ldlr mRNA and ( G ) Pcsk9 mRNA expressions. Values are reported as relative arbitrary unit (AU) levels obtained by RT-qPCR and normalized to Rn18s. ( H ) Hepatic levels of 25-hydroxycholesterol. ( I ) Morphometric changes in lipid droplet area expressed as a percentage of the total liver section. Data are shown as means ± SD with their individual values of 4 WT and 6 homozygous Cyp7b1 -deficient (KO) rats. Statistical analysis was performed using the Mann–Whitney U-test. * p < 0.05, ** p < 0.02, *** p < 0.01, and **** p < 0.001 vs. control.

Techniques: Western Blot, Clinical Proteomics, Membrane, Binding Assay, Control, Quantitative RT-PCR, MANN-WHITNEY

Postprandial analyses of male rats eight hours after receiving a fat bolus . ( A ) 16 h fasted male rats received an intragastrical administration of 5 mL of virgin olive oil (16 mL kg −1 ). Differential values of plasma TG eight hours after the oral gavage minus those from basal values are shown as individual, mean, and standard deviation values for wild-type (WT, n = 8) and homozygous KO (n = 17). Statistical analysis was performed using the Mann–Whitney U test. * p < 0.05 and *** p < 0.001 vs. control. Plasma lipoproteins were separated by FPLC and their APOA4 contents are reflected in panel ( B ). Their cholesterol and phosphatidylcholine (PC) contents are depicted in ( C , D ), respectively. Open squares correspond to wild-type and black triangles to homozygous Cyp7b1 -deficient rats. ( E ) Hepatic levels of 25-hydroxycholesterol of rats sacrificed eight hours after the oral gavage. ( F ) Morphometric changes in the lipid droplet area expressed as a percentage of the total liver section. ( G ) Association between hepatic Abca1 expression and levels of 25-hydroxycholesterol. Spearman’s ρ coefficient and significance are shown.

Journal: International Journal of Molecular Sciences

Article Title: The Disruption of Cyp7b1 Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites

doi: 10.3390/ijms262411994

Figure Lengend Snippet: Postprandial analyses of male rats eight hours after receiving a fat bolus . ( A ) 16 h fasted male rats received an intragastrical administration of 5 mL of virgin olive oil (16 mL kg −1 ). Differential values of plasma TG eight hours after the oral gavage minus those from basal values are shown as individual, mean, and standard deviation values for wild-type (WT, n = 8) and homozygous KO (n = 17). Statistical analysis was performed using the Mann–Whitney U test. * p < 0.05 and *** p < 0.001 vs. control. Plasma lipoproteins were separated by FPLC and their APOA4 contents are reflected in panel ( B ). Their cholesterol and phosphatidylcholine (PC) contents are depicted in ( C , D ), respectively. Open squares correspond to wild-type and black triangles to homozygous Cyp7b1 -deficient rats. ( E ) Hepatic levels of 25-hydroxycholesterol of rats sacrificed eight hours after the oral gavage. ( F ) Morphometric changes in the lipid droplet area expressed as a percentage of the total liver section. ( G ) Association between hepatic Abca1 expression and levels of 25-hydroxycholesterol. Spearman’s ρ coefficient and significance are shown.

Techniques: Clinical Proteomics, Standard Deviation, MANN-WHITNEY, Control, Expressing

Differentially expressed genes according to Cyp7b1 deficiency in rats. ( A ) Hepatic Cyp7b1 mRNA expression in WT (n = 8), homozygous Cyp7b1 -deficient (KO, n = 10), and homozygous Cyp7b1 -deficient (n = 4) rats rescued by hydrodynamic expression of pLIVE- Cyp7b1 (rescued KO) using RT-qPCR. ( B ) Venn diagram analysis showing the significant transcripts (false discovery rate < 0.01) among the different groups using RNAseq from the livers. ( C ) Hepatic expression of Fasn , Igfbp2 , and Pcsk9 normalized to Rn18s using RT-qPCR. ( D ) Significant association among gene expressions. Spearman’s ρ correlation coefficients are shown. ( E ) Western blot analysis of hepatic protein expressions of the non-glycosylated IGFBP2 isoform of 36 kDa normalized to ACTIN ( left ) and of the glycosylated IGFBP2 isoform of 50 kDa normalized to ACTIN ( right ). ( F ) Plasma protein content of PSK9 (74 kDa) normalized to total protein loaded into the gel. Data are shown as individual, means ± SD. Statistical analysis was performed using the Mann–Whitney U-test. ** p < 0.02 and *** p < 0.01 vs. control. ( G ) Ldlr and ( H ) Mylip expressions normalized to Rn18s using RT-qPCR. Data are means ± SD of arbitrary units. Statistical analysis was performed using one-way ANOVA and Tukey’s post hoc test. * p < 0.05, ** p < 0.02, *** p < 0.001, and **** p < 0.0001.

Journal: International Journal of Molecular Sciences

Article Title: The Disruption of Cyp7b1 Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites

doi: 10.3390/ijms262411994

Figure Lengend Snippet: Differentially expressed genes according to Cyp7b1 deficiency in rats. ( A ) Hepatic Cyp7b1 mRNA expression in WT (n = 8), homozygous Cyp7b1 -deficient (KO, n = 10), and homozygous Cyp7b1 -deficient (n = 4) rats rescued by hydrodynamic expression of pLIVE- Cyp7b1 (rescued KO) using RT-qPCR. ( B ) Venn diagram analysis showing the significant transcripts (false discovery rate < 0.01) among the different groups using RNAseq from the livers. ( C ) Hepatic expression of Fasn , Igfbp2 , and Pcsk9 normalized to Rn18s using RT-qPCR. ( D ) Significant association among gene expressions. Spearman’s ρ correlation coefficients are shown. ( E ) Western blot analysis of hepatic protein expressions of the non-glycosylated IGFBP2 isoform of 36 kDa normalized to ACTIN ( left ) and of the glycosylated IGFBP2 isoform of 50 kDa normalized to ACTIN ( right ). ( F ) Plasma protein content of PSK9 (74 kDa) normalized to total protein loaded into the gel. Data are shown as individual, means ± SD. Statistical analysis was performed using the Mann–Whitney U-test. ** p < 0.02 and *** p < 0.01 vs. control. ( G ) Ldlr and ( H ) Mylip expressions normalized to Rn18s using RT-qPCR. Data are means ± SD of arbitrary units. Statistical analysis was performed using one-way ANOVA and Tukey’s post hoc test. * p < 0.05, ** p < 0.02, *** p < 0.001, and **** p < 0.0001.

Techniques: Expressing, Quantitative RT-PCR, Western Blot, Clinical Proteomics, MANN-WHITNEY, Control

Characterization of a stable human CYP7B1 -knockout HepG2 cell line. ( A ) Levels of oxysterols: 4β-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol. ( B ) Gene expressions of FASN , IGFBP2 , and PCSK9 normalized to PPIB in wild-type (WT) and CYP7B1 -knockout (KO) HepG2 cells. ( C ) FASN , IGFBP2 , and PCSK9 gene expressions of wild-type HepG2 cells incubated with 250 nM 4β-hydroxycholesterol (4β-HC), 25-hydroxycholesterol (25-HC), or 27-hydroxycholesterol (27-HC) for 24 h. ( D ) Gene expressions of CYP7B1 -KO HepG2 cells incubated with 250 nM 4β-hydroxycholesterol (4β-HC), 25-hydroxycholesterol (25-HC), or 27-hydroxycholesterol (27-HC) for 24 h. Data are shown as individual, means ± SD of four replicates except for 4β-hydroxycholesterol (eight replicates). Statistical analysis was performed using one-way ANOVA and Tukey’s post hoc test or Mann–Whitney’s U test. * p < 0.05 and ** p < 0.02.

Journal: International Journal of Molecular Sciences

Article Title: The Disruption of Cyp7b1 Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites

doi: 10.3390/ijms262411994

Figure Lengend Snippet: Characterization of a stable human CYP7B1 -knockout HepG2 cell line. ( A ) Levels of oxysterols: 4β-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol. ( B ) Gene expressions of FASN , IGFBP2 , and PCSK9 normalized to PPIB in wild-type (WT) and CYP7B1 -knockout (KO) HepG2 cells. ( C ) FASN , IGFBP2 , and PCSK9 gene expressions of wild-type HepG2 cells incubated with 250 nM 4β-hydroxycholesterol (4β-HC), 25-hydroxycholesterol (25-HC), or 27-hydroxycholesterol (27-HC) for 24 h. ( D ) Gene expressions of CYP7B1 -KO HepG2 cells incubated with 250 nM 4β-hydroxycholesterol (4β-HC), 25-hydroxycholesterol (25-HC), or 27-hydroxycholesterol (27-HC) for 24 h. Data are shown as individual, means ± SD of four replicates except for 4β-hydroxycholesterol (eight replicates). Statistical analysis was performed using one-way ANOVA and Tukey’s post hoc test or Mann–Whitney’s U test. * p < 0.05 and ** p < 0.02.

Techniques: Knock-Out, Incubation

Summary of phenotype of Cyp7b1 deficiency in rats. The absence of this enzyme increases levels of 25-HC and through this, broad metabolic control is exerted on FASN, IGFBP2, PCSK9, LDLR, SCD1, ABCA1, and LRP1. Created in Biorender.com, Osada (2025), https://app.biorender.com/illustrations/67ddc3c130709ae66c1676b6 .

Journal: International Journal of Molecular Sciences

Article Title: The Disruption of Cyp7b1 Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites

doi: 10.3390/ijms262411994

Figure Lengend Snippet: Summary of phenotype of Cyp7b1 deficiency in rats. The absence of this enzyme increases levels of 25-HC and through this, broad metabolic control is exerted on FASN, IGFBP2, PCSK9, LDLR, SCD1, ABCA1, and LRP1. Created in Biorender.com, Osada (2025), https://app.biorender.com/illustrations/67ddc3c130709ae66c1676b6 .

Techniques: Control

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