Journal: Nephrology Dialysis Transplantation
Article Title: Plasmacytoid dendritic cells modulate the production of mucosal IgA in IgA nephropathy
doi: 10.1093/ndt/gfaf216
Figure Lengend Snippet: Frequency of tonsillar pDCs positively correlates with the expression of mRNAs encoding APRIL, BAFF and TLR9 in tonsillar MNCs from patients with IgAN. Correlation analysis was performed between the frequency of tonsillar pDCs and gene expression in tonsillar MNCs from patients with IgAN ( n = 10, red dots) and CT ( n = 9, black dots). ( A ) Correlation between the percentage of tonsillar pDCs and the expression of TLR9 in tonsillar MNCs from patients with IgAN and CT. ( B ) Correlation between the percentage of tonsillar pDCs and the expression of IL-6 in tonsillar MNCs from patients with IgAN and CT. ( C ) Correlation between the percentage of tonsillar pDCs and the expression of BAFF in tonsillar MNCs from patients with IgAN and CT. ( D ) Correlation between the percentage of tonsillar pDCs and the expression of APRIL in tonsillar MNCs from patients with IgAN and CT. Spearman’s correlation coefficients (r) and P -values are shown in each panel. * P ≤ .05.
Article Snippet: The TLR9 agonist class C CpG-ODN (ODN 2395, InvivoGen), which stimulates pDCs and B cells [ ], was intranasally administered to each group of mice every 2 days for 3 weeks.
Techniques: Expressing, Gene Expression