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cordycepin  (TargetMol)


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    TargetMol cordycepin
    Cordycepin, supplied by TargetMol, used in various techniques. Bioz Stars score: 96/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cordycepin/product/TargetMol
    Average 96 stars, based on 7 article reviews
    cordycepin - by Bioz Stars, 2026-03
    96/100 stars

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    CLS combination synergistically reduces RSV infection and enhances macrophage survival compared to cordycepin monotherapy in RSV-infected cells. (A) Immunofluorescence staining of RSV-F (red, with blue DAPI nuclei) in alveolar macrophages (AMs) across experimental groups: ​AM controls, ​RSV-infected, ​RSV+CLS, and ​RSV+Cordycepin (CD)​. Scale bar: 20 µm. (B) RSV mRNA expression levels. (C) Dual immunofluorescence for M1 marker iNOS (red) and M2 marker CD206 (green) with DAPI nuclei (blue). Scale bar: 20 µm. (D) Levels of LDH in culture supernatants indicate cytotoxicity. (E) CCK-8 analysis of macrophage proliferation. (F) EdU staining of macrophages. Scale bar: 200 µm. Data are presented as mean ± SD; n=6 per group. * P <0.05, ** P <0.01, *** P <0.001, ns P >0.05 (one-way ANOVA with Tukey’s post hoc ).

    Journal: Frontiers in Immunology

    Article Title: Cordycepin, lactoferrin, and Sargassum fusiforme polysaccharides protects against RSV via M2-like macrophage polarization

    doi: 10.3389/fimmu.2025.1576069

    Figure Lengend Snippet: CLS combination synergistically reduces RSV infection and enhances macrophage survival compared to cordycepin monotherapy in RSV-infected cells. (A) Immunofluorescence staining of RSV-F (red, with blue DAPI nuclei) in alveolar macrophages (AMs) across experimental groups: ​AM controls, ​RSV-infected, ​RSV+CLS, and ​RSV+Cordycepin (CD)​. Scale bar: 20 µm. (B) RSV mRNA expression levels. (C) Dual immunofluorescence for M1 marker iNOS (red) and M2 marker CD206 (green) with DAPI nuclei (blue). Scale bar: 20 µm. (D) Levels of LDH in culture supernatants indicate cytotoxicity. (E) CCK-8 analysis of macrophage proliferation. (F) EdU staining of macrophages. Scale bar: 200 µm. Data are presented as mean ± SD; n=6 per group. * P <0.05, ** P <0.01, *** P <0.001, ns P >0.05 (one-way ANOVA with Tukey’s post hoc ).

    Article Snippet: Reagents used were as follows: CLS (Cordycepin, Lactoferrin, Sargassum fusiforme polysaccharides, REGENERON, USA), ribavirin (R9644, Sigma-Aldrich, USA), Clodronate liposomes (40337ES08, Yeasen, China), human RSV strain A2 (Wuhan University Virus Institute, China).

    Techniques: Infection, Immunofluorescence, Staining, Expressing, Marker, CCK-8 Assay

    CLS synergy amplifies M2-like polarization in RSV-infected alveolar macrophages beyond cordycepin alone. (A) Flow cytometry analysis of F4/80 + iNOS + M1 cells and F4/80 + CD206 + M2 cells. (B) RT-qPCR results of M1 marker mRNA (iNOS, IL-1β, IL-6, and TNF-α) and M2 marker mRNA (Arg-1, CD206, IL-10, and TGF-β) expression. Data are shown as mean ± SD; n=6 per group. * P <0.05, ** P <0.01, *** P <0.001, ns P >0.05 (one-way ANOVA with Tukey’s post hoc ).

    Journal: Frontiers in Immunology

    Article Title: Cordycepin, lactoferrin, and Sargassum fusiforme polysaccharides protects against RSV via M2-like macrophage polarization

    doi: 10.3389/fimmu.2025.1576069

    Figure Lengend Snippet: CLS synergy amplifies M2-like polarization in RSV-infected alveolar macrophages beyond cordycepin alone. (A) Flow cytometry analysis of F4/80 + iNOS + M1 cells and F4/80 + CD206 + M2 cells. (B) RT-qPCR results of M1 marker mRNA (iNOS, IL-1β, IL-6, and TNF-α) and M2 marker mRNA (Arg-1, CD206, IL-10, and TGF-β) expression. Data are shown as mean ± SD; n=6 per group. * P <0.05, ** P <0.01, *** P <0.001, ns P >0.05 (one-way ANOVA with Tukey’s post hoc ).

    Article Snippet: Reagents used were as follows: CLS (Cordycepin, Lactoferrin, Sargassum fusiforme polysaccharides, REGENERON, USA), ribavirin (R9644, Sigma-Aldrich, USA), Clodronate liposomes (40337ES08, Yeasen, China), human RSV strain A2 (Wuhan University Virus Institute, China).

    Techniques: Infection, Flow Cytometry, Quantitative RT-PCR, Marker, Expressing