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columbamine  (TargetMol)


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    TargetMol columbamine
    Phytochemical components of Sinomenium acutum via UHPLC-MS/MS.
    Columbamine, supplied by TargetMol, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/columbamine/product/TargetMol
    Average 92 stars, based on 1 article reviews
    columbamine - by Bioz Stars, 2026-02
    92/100 stars

    Images

    1) Product Images from "Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice"

    Article Title: Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice

    Journal: Pharmaceuticals

    doi: 10.3390/ph17010006

    Phytochemical components of Sinomenium acutum via UHPLC-MS/MS.
    Figure Legend Snippet: Phytochemical components of Sinomenium acutum via UHPLC-MS/MS.

    Techniques Used:

    Ultra-high-performance liquid chromatography–tandem mass spectrometry examination of Sinomenium acutum . ( A ) Base peak chromatogram of Sinomenium acutum in positive and negative ion mode. ( B ) Elicit ion chromatogram of Sinomenium acutum . 1, higenamine; 2, acutumidine; 3, acutumine; 4, sinomenine; 5, gelsemine; 6, magnoflorine; 7, scopoletin; 8, columbamine or jatrorrhizine; 9, palmatine; 10, syringin; 11, eleutheroside E.
    Figure Legend Snippet: Ultra-high-performance liquid chromatography–tandem mass spectrometry examination of Sinomenium acutum . ( A ) Base peak chromatogram of Sinomenium acutum in positive and negative ion mode. ( B ) Elicit ion chromatogram of Sinomenium acutum . 1, higenamine; 2, acutumidine; 3, acutumine; 4, sinomenine; 5, gelsemine; 6, magnoflorine; 7, scopoletin; 8, columbamine or jatrorrhizine; 9, palmatine; 10, syringin; 11, eleutheroside E.

    Techniques Used: High Performance Liquid Chromatography, Mass Spectrometry



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    The representative MRM chromatograms of mixed reference solution and samples of Coptis rhizome. (A) mixed reference solution, (B) test solution of Coptis chinensis rhizome, (C) test solution of Coptis deltoidea rhizome, (D) test solution of Coptis teeta rhizome, and (E) test solution of Coptis japonica rhizome. 1. magnoflorine, 2. tetrahydricheilanthifolinium, 3. coptisine, 4. epiberberine, 5. <t>columbamine,</t> 6. jatrorrhizine, 7. berberrubine, 8. berberine, 9. palmatine, 10. berlambine.
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    Berberine and berberine-derived metabolites in plasma (top), ileum (middle) or caecum (bottom) from chickens fed a berberine-supplemented diet (0.1, 0.5 or 1 g/kg feed) for 21 days post-hatch (n = 12). (A) Log 10 concentration profiles of berberine, phase I and cumulated phase II berberine metabolites. (B) Concentration profiles of phase II glucuronide and sulfate berberine metabolites. The shade area represents the 95% confidence interval. Total glucuronides and sulfates represent cumulated phase II berberine metabolites and include berberrubine-glucuronide/-sulfate, <t>columbamine-glucuronide/-sulfate,</t> jatrorrhizine-glucuronide/-sulfate, demethyleneberberine-glucuronide/-sulfate01/02/03/04/05/06, thalifendine-glucuronide/-sulfate. Oxyberberine, columbamine, demethyleneberberine_sulfate01/02/05/06 were not detected in the plasma. Colu-gluc/-sulf: columbamine-glucuronide/-sulfate; Jatr-gluc/-sulf: jatrorrhizine-glucuronide/-sulfate; Deme-gluc/-sulf: demethyleneberberine-glucuronide/-sulfate; Thal-gluc: thalifendine-glucuronide; Berb-gluc/-sulf: berberrubine-glucuronide/-sulfate.
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    Image Search Results


    The representative MRM chromatograms of mixed reference solution and samples of Coptis rhizome. (A) mixed reference solution, (B) test solution of Coptis chinensis rhizome, (C) test solution of Coptis deltoidea rhizome, (D) test solution of Coptis teeta rhizome, and (E) test solution of Coptis japonica rhizome. 1. magnoflorine, 2. tetrahydricheilanthifolinium, 3. coptisine, 4. epiberberine, 5. columbamine, 6. jatrorrhizine, 7. berberrubine, 8. berberine, 9. palmatine, 10. berlambine.

    Journal: Frontiers in Plant Science

    Article Title: Study on the correlation between alkaloids and tastes of Coptis Rhizome from four species based on UHPLC-QQQ-MS/MS combined with electronic tongue technique

    doi: 10.3389/fpls.2024.1496789

    Figure Lengend Snippet: The representative MRM chromatograms of mixed reference solution and samples of Coptis rhizome. (A) mixed reference solution, (B) test solution of Coptis chinensis rhizome, (C) test solution of Coptis deltoidea rhizome, (D) test solution of Coptis teeta rhizome, and (E) test solution of Coptis japonica rhizome. 1. magnoflorine, 2. tetrahydricheilanthifolinium, 3. coptisine, 4. epiberberine, 5. columbamine, 6. jatrorrhizine, 7. berberrubine, 8. berberine, 9. palmatine, 10. berlambine.

    Article Snippet: Chemical reference substances (CRS), such as magnoflorine, tetrahydricheilanthifolinium, coptisine, epiberberine, columbamine, jatrorrhizine, berberrubine, berberine, palmatine, berlambine (purity ≥98%, HPLC grade), were purchased from Shanghai Yuanye Bio-Technology Co., Ltd. (Shanghai, China).

    Techniques:

    The contents of ten alkaloids from four species of Coptis rhizome.

    Journal: Frontiers in Plant Science

    Article Title: Study on the correlation between alkaloids and tastes of Coptis Rhizome from four species based on UHPLC-QQQ-MS/MS combined with electronic tongue technique

    doi: 10.3389/fpls.2024.1496789

    Figure Lengend Snippet: The contents of ten alkaloids from four species of Coptis rhizome.

    Article Snippet: Chemical reference substances (CRS), such as magnoflorine, tetrahydricheilanthifolinium, coptisine, epiberberine, columbamine, jatrorrhizine, berberrubine, berberine, palmatine, berlambine (purity ≥98%, HPLC grade), were purchased from Shanghai Yuanye Bio-Technology Co., Ltd. (Shanghai, China).

    Techniques:

    The correlation analysis of tastes and alkaloids for Coptis rhizome.

    Journal: Frontiers in Plant Science

    Article Title: Study on the correlation between alkaloids and tastes of Coptis Rhizome from four species based on UHPLC-QQQ-MS/MS combined with electronic tongue technique

    doi: 10.3389/fpls.2024.1496789

    Figure Lengend Snippet: The correlation analysis of tastes and alkaloids for Coptis rhizome.

    Article Snippet: Chemical reference substances (CRS), such as magnoflorine, tetrahydricheilanthifolinium, coptisine, epiberberine, columbamine, jatrorrhizine, berberrubine, berberine, palmatine, berlambine (purity ≥98%, HPLC grade), were purchased from Shanghai Yuanye Bio-Technology Co., Ltd. (Shanghai, China).

    Techniques:

    Phytochemical components of Sinomenium acutum via UHPLC-MS/MS.

    Journal: Pharmaceuticals

    Article Title: Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice

    doi: 10.3390/ph17010006

    Figure Lengend Snippet: Phytochemical components of Sinomenium acutum via UHPLC-MS/MS.

    Article Snippet: The latter included higenamine, gelsemine, magnoflorine, scopoletin, columbamine, jatrorrhizine, palmatine, syringin, and eleutheroside E, which were purchased from TargetMol (Wellesley Hills, MA, USA).

    Techniques:

    Ultra-high-performance liquid chromatography–tandem mass spectrometry examination of Sinomenium acutum . ( A ) Base peak chromatogram of Sinomenium acutum in positive and negative ion mode. ( B ) Elicit ion chromatogram of Sinomenium acutum . 1, higenamine; 2, acutumidine; 3, acutumine; 4, sinomenine; 5, gelsemine; 6, magnoflorine; 7, scopoletin; 8, columbamine or jatrorrhizine; 9, palmatine; 10, syringin; 11, eleutheroside E.

    Journal: Pharmaceuticals

    Article Title: Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice

    doi: 10.3390/ph17010006

    Figure Lengend Snippet: Ultra-high-performance liquid chromatography–tandem mass spectrometry examination of Sinomenium acutum . ( A ) Base peak chromatogram of Sinomenium acutum in positive and negative ion mode. ( B ) Elicit ion chromatogram of Sinomenium acutum . 1, higenamine; 2, acutumidine; 3, acutumine; 4, sinomenine; 5, gelsemine; 6, magnoflorine; 7, scopoletin; 8, columbamine or jatrorrhizine; 9, palmatine; 10, syringin; 11, eleutheroside E.

    Article Snippet: The latter included higenamine, gelsemine, magnoflorine, scopoletin, columbamine, jatrorrhizine, palmatine, syringin, and eleutheroside E, which were purchased from TargetMol (Wellesley Hills, MA, USA).

    Techniques: High Performance Liquid Chromatography, Mass Spectrometry

    Berberine and berberine-derived metabolites in plasma (top), ileum (middle) or caecum (bottom) from chickens fed a berberine-supplemented diet (0.1, 0.5 or 1 g/kg feed) for 21 days post-hatch (n = 12). (A) Log 10 concentration profiles of berberine, phase I and cumulated phase II berberine metabolites. (B) Concentration profiles of phase II glucuronide and sulfate berberine metabolites. The shade area represents the 95% confidence interval. Total glucuronides and sulfates represent cumulated phase II berberine metabolites and include berberrubine-glucuronide/-sulfate, columbamine-glucuronide/-sulfate, jatrorrhizine-glucuronide/-sulfate, demethyleneberberine-glucuronide/-sulfate01/02/03/04/05/06, thalifendine-glucuronide/-sulfate. Oxyberberine, columbamine, demethyleneberberine_sulfate01/02/05/06 were not detected in the plasma. Colu-gluc/-sulf: columbamine-glucuronide/-sulfate; Jatr-gluc/-sulf: jatrorrhizine-glucuronide/-sulfate; Deme-gluc/-sulf: demethyleneberberine-glucuronide/-sulfate; Thal-gluc: thalifendine-glucuronide; Berb-gluc/-sulf: berberrubine-glucuronide/-sulfate.

    Journal: Frontiers in Pharmacology

    Article Title: Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites

    doi: 10.3389/fphar.2023.1281090

    Figure Lengend Snippet: Berberine and berberine-derived metabolites in plasma (top), ileum (middle) or caecum (bottom) from chickens fed a berberine-supplemented diet (0.1, 0.5 or 1 g/kg feed) for 21 days post-hatch (n = 12). (A) Log 10 concentration profiles of berberine, phase I and cumulated phase II berberine metabolites. (B) Concentration profiles of phase II glucuronide and sulfate berberine metabolites. The shade area represents the 95% confidence interval. Total glucuronides and sulfates represent cumulated phase II berberine metabolites and include berberrubine-glucuronide/-sulfate, columbamine-glucuronide/-sulfate, jatrorrhizine-glucuronide/-sulfate, demethyleneberberine-glucuronide/-sulfate01/02/03/04/05/06, thalifendine-glucuronide/-sulfate. Oxyberberine, columbamine, demethyleneberberine_sulfate01/02/05/06 were not detected in the plasma. Colu-gluc/-sulf: columbamine-glucuronide/-sulfate; Jatr-gluc/-sulf: jatrorrhizine-glucuronide/-sulfate; Deme-gluc/-sulf: demethyleneberberine-glucuronide/-sulfate; Thal-gluc: thalifendine-glucuronide; Berb-gluc/-sulf: berberrubine-glucuronide/-sulfate.

    Article Snippet: Demethyleneberberine (purity >98%), columbamine (purity >98%) and dihydroberberine (purity >95%), were purchased at AbMole BioScience (Brussels, Belgium).

    Techniques: Derivative Assay, Clinical Proteomics, Concentration Assay

    Comparison of log 10 concentration profiles of berberine and berberine-derived metabolites between ileum (yellow) and caecum (purple) from chickens fed a berberine-supplemented diet (0.1, 0.5 or 1 g/kg feed) for 21 days post-hatch (n = 12). Total glucuronides and sulfates represent cumulated phase II berberine metabolites and include berberrubine-glucuronide/-sulfate, columbamine-glucuronide/-sulfate, jatrorrhizine-glucuronide/-sulfate, demethyleneberberine-glucuronide/-sulfate_01/_02/_03/_04/_05/_05/_06, thalifendine-glucuronide/-sulfate. reports concentrations profiles in plasma.

    Journal: Frontiers in Pharmacology

    Article Title: Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites

    doi: 10.3389/fphar.2023.1281090

    Figure Lengend Snippet: Comparison of log 10 concentration profiles of berberine and berberine-derived metabolites between ileum (yellow) and caecum (purple) from chickens fed a berberine-supplemented diet (0.1, 0.5 or 1 g/kg feed) for 21 days post-hatch (n = 12). Total glucuronides and sulfates represent cumulated phase II berberine metabolites and include berberrubine-glucuronide/-sulfate, columbamine-glucuronide/-sulfate, jatrorrhizine-glucuronide/-sulfate, demethyleneberberine-glucuronide/-sulfate_01/_02/_03/_04/_05/_05/_06, thalifendine-glucuronide/-sulfate. reports concentrations profiles in plasma.

    Article Snippet: Demethyleneberberine (purity >98%), columbamine (purity >98%) and dihydroberberine (purity >95%), were purchased at AbMole BioScience (Brussels, Belgium).

    Techniques: Comparison, Concentration Assay, Derivative Assay, Clinical Proteomics