Review



cmpd43  (Tocris)


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    Structured Review

    Tocris cmpd43
    The effects of the test compounds and FPR peptide agonists on the LPS-induced NF-κB activity in human THP1-Blue cells, cytotoxicity, and Ca 2+ mobilization in FPR1/FPR2-transfected HL-60 cells.
    Cmpd43, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cmpd43/product/Tocris
    Average 92 stars, based on 2 article reviews
    cmpd43 - by Bioz Stars, 2026-04
    92/100 stars

    Images

    1) Product Images from "Pyridazinones and Structurally Related Derivatives with Anti-Inflammatory Activity"

    Article Title: Pyridazinones and Structurally Related Derivatives with Anti-Inflammatory Activity

    Journal: Molecules

    doi: 10.3390/molecules27123749

    The effects of the test compounds and FPR peptide agonists on the LPS-induced NF-κB activity in human THP1-Blue cells, cytotoxicity, and Ca 2+ mobilization in FPR1/FPR2-transfected HL-60 cells.
    Figure Legend Snippet: The effects of the test compounds and FPR peptide agonists on the LPS-induced NF-κB activity in human THP1-Blue cells, cytotoxicity, and Ca 2+ mobilization in FPR1/FPR2-transfected HL-60 cells.

    Techniques Used: Activity Assay, Inhibition



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    Image Search Results


    Current and former human FPR family receptor nomenclature and their agonists

    Journal: British Journal of Pharmacology

    Article Title: Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35

    doi: 10.1111/bph.15919

    Figure Lengend Snippet: Current and former human FPR family receptor nomenclature and their agonists

    Article Snippet: Coronary artery occlusion with reperfusion (male Sprague Dawley rats) , Cmpd43 oral gavage , ↑ viable LV myocardium, ↓ LV dilatation, preserved LV function.

    Techniques:

    Selected diseases identified as amenable to FPR2‐targeted intervention in vivo to date

    Journal: British Journal of Pharmacology

    Article Title: Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35

    doi: 10.1111/bph.15919

    Figure Lengend Snippet: Selected diseases identified as amenable to FPR2‐targeted intervention in vivo to date

    Article Snippet: Coronary artery occlusion with reperfusion (male Sprague Dawley rats) , Cmpd43 oral gavage , ↑ viable LV myocardium, ↓ LV dilatation, preserved LV function.

    Techniques: In Vivo, Adjuvant, Activation Assay, Gene Expression, Expressing, Clinical Proteomics, Control

    The effects of the test compounds and FPR peptide agonists on the LPS-induced NF-κB activity in human THP1-Blue cells, cytotoxicity, and Ca 2+ mobilization in FPR1/FPR2-transfected HL-60 cells.

    Journal: Molecules

    Article Title: Pyridazinones and Structurally Related Derivatives with Anti-Inflammatory Activity

    doi: 10.3390/molecules27123749

    Figure Lengend Snippet: The effects of the test compounds and FPR peptide agonists on the LPS-induced NF-κB activity in human THP1-Blue cells, cytotoxicity, and Ca 2+ mobilization in FPR1/FPR2-transfected HL-60 cells.

    Article Snippet: Cmpd43 (TC-FPR 43) and Boc-MLF were purchased from Tocris Biosciences (Bristol, UK).

    Techniques: Activity Assay, Inhibition

    Journal: eLife

    Article Title: Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

    doi: 10.7554/eLife.74101

    Figure Lengend Snippet:

    Article Snippet: Chemical compound, drug , Cmpd43 , Provided by Bristol-Myers Squibb , N/A , .

    Techniques: Functional Assay, Transfection, Construct, Plasmid Preparation, Software, Inverted Microscopy