Journal: Journal of Sport and Health Science
Article Title: Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice
doi: 10.1016/j.jshs.2025.101100
Figure Lengend Snippet: Endurance and resistance exercise training differentially impact endurance exercise capacity and fat accumulation in response to HFD feeding. (A) Male C57BL/6J mice (8–10 weeks) were separated into 4 groups differentiated by diet (normal chow vs . HFD) and exercise (sedentary vs . weightlifting (R EX ) or voluntary wheel running (E EX )) with endpoint measures made after 8 weeks of treatment. Body weight was measured weekly, and body composition was determined at the end of the study. (B) Weightlifting model and cage for R EX . (C) R EX began with 100% body weight load and increased by 20% daily until achieving 240% body weight load (8 days) where it remained for the entirety of the study. (D) Average daily lifts (repetitions) for R EX and (E) average daily kilometers for E EX . (F) Body weight gain over study period. Colored * indicates significant difference from NC-SED. (G) Body weight at endpoint. (H and I) Body composition measurements by EchoMRI for fat mass (% BW) and lean mass (g/mm tibia length). (J–L) Weight of epididymal fat, inguinal fat, and brown fat (mg) normalized by tibia length (mm). Data presented as mean ± standard error of the mean. Statistical analysis performed by analysis of variance among groups: * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. NC-SED n : 8–16 (white); HFD-SED n : 8–18 (red); HFD-R EX n : 10–16 (blue); HFD-E EX n : 8–15 (green). BW = body weight; E EX = endurance exercise; ETT = exercise tolerance test; GTT = glucose tolerance test; HFD = high-fat diet; HOMA-IR = homeostatic model assessment for insulin resistance; ITT = insulin tolerance test; NC = normal chow; R EX = resistance exercise; SED = sedentary; VWR = voluntary weightlifting.
Article Snippet: Male C57BL/6J mice (8–10 weeks) were purchased from the Jackson Lab (Bar Harbor, ME, USA) and housed in the animal care facility under 12-h light and dark cycle standard conditions.
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