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plxnc1  (Bioss)


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    Structured Review

    Bioss plxnc1
    MR analysis showed a causative relationship between the biomarkers and CCA. a The scatterplots represent the causal effects of GRN ( a1 ), <t>PLXNC1</t> ( a2 ), and ORMDL3 ( a3 ) on CCA. b The forest plots present the prominent overall effect of GRN ( b1 ), PLXNC1 ( b2 ) and ORMDL3 ( b3 ) on CCA. c The funnel plots showing the most valid IVs of three exposure factors (GRN [ c1 ], PLXNC1 [ c2 ], and ORMDL3 [ c3 ]) were distributed symmetrically. d The forest plots mean the leave-one-out sensitivity analysis results for three biomarkers (GRN [ d1 ], PLXNC1 [ d2 ], and ORMDL3 [ d3 ]).)
    Plxnc1, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/plxnc1/product/Bioss
    Average 93 stars, based on 1 article reviews
    plxnc1 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Identification of cancer-associated fibroblast signature genes for potential biomarkers in cholangiocarcinoma: a Mendelian randomization study"

    Article Title: Identification of cancer-associated fibroblast signature genes for potential biomarkers in cholangiocarcinoma: a Mendelian randomization study

    Journal: Discover Oncology

    doi: 10.1007/s12672-025-04286-1

    MR analysis showed a causative relationship between the biomarkers and CCA. a The scatterplots represent the causal effects of GRN ( a1 ), PLXNC1 ( a2 ), and ORMDL3 ( a3 ) on CCA. b The forest plots present the prominent overall effect of GRN ( b1 ), PLXNC1 ( b2 ) and ORMDL3 ( b3 ) on CCA. c The funnel plots showing the most valid IVs of three exposure factors (GRN [ c1 ], PLXNC1 [ c2 ], and ORMDL3 [ c3 ]) were distributed symmetrically. d The forest plots mean the leave-one-out sensitivity analysis results for three biomarkers (GRN [ d1 ], PLXNC1 [ d2 ], and ORMDL3 [ d3 ]).)
    Figure Legend Snippet: MR analysis showed a causative relationship between the biomarkers and CCA. a The scatterplots represent the causal effects of GRN ( a1 ), PLXNC1 ( a2 ), and ORMDL3 ( a3 ) on CCA. b The forest plots present the prominent overall effect of GRN ( b1 ), PLXNC1 ( b2 ) and ORMDL3 ( b3 ) on CCA. c The funnel plots showing the most valid IVs of three exposure factors (GRN [ c1 ], PLXNC1 [ c2 ], and ORMDL3 [ c3 ]) were distributed symmetrically. d The forest plots mean the leave-one-out sensitivity analysis results for three biomarkers (GRN [ d1 ], PLXNC1 [ d2 ], and ORMDL3 [ d3 ]).)

    Techniques Used:

    The analysis focused on the diagnostic performance and expression levels of the biomarkers. The ROC curves were analyzed for three biomarkers, namely GRN, PLXNC1, and ORMDL3, in GSE107943 ( a ), TCGA-CHOL ( b ), and E-MTAB-6389 ( c ). The box plot compares the expression levels of GRN, PLXNC1, and ORMDL3 in GSE107943 ( d ), TCGA-CHOL ( e ), and E-MTAB-6389 ( f )
    Figure Legend Snippet: The analysis focused on the diagnostic performance and expression levels of the biomarkers. The ROC curves were analyzed for three biomarkers, namely GRN, PLXNC1, and ORMDL3, in GSE107943 ( a ), TCGA-CHOL ( b ), and E-MTAB-6389 ( c ). The box plot compares the expression levels of GRN, PLXNC1, and ORMDL3 in GSE107943 ( d ), TCGA-CHOL ( e ), and E-MTAB-6389 ( f )

    Techniques Used: Diagnostic Assay, Expressing

    The process begins with the establishment of the nomogram. a The construction of the nomogram based on GRN, PLXNC1, and ORMDL3. b The calibration curve of nomograms. c The decision curve analysis (DCA) of nomograms
    Figure Legend Snippet: The process begins with the establishment of the nomogram. a The construction of the nomogram based on GRN, PLXNC1, and ORMDL3. b The calibration curve of nomograms. c The decision curve analysis (DCA) of nomograms

    Techniques Used:

    The single gene GSEA on the basis of KEGG gene set of GRN ( a ), PLXNC1 ( b ) and ORMDL3 ( c )
    Figure Legend Snippet: The single gene GSEA on the basis of KEGG gene set of GRN ( a ), PLXNC1 ( b ) and ORMDL3 ( c )

    Techniques Used:

    a RT-PCR detection showed that the ca group showed high expressions of GRN, PLXNC1 and ORMDL3 compared with the cap group, and the difference between GRN and ORMDL3 was statistically significant (P < 0.05). b WB showed that the expressions of GRN and ORMDL3 were significantly increased in the ca group and the cap group (P < 0.05) and PLXNC1 increased (P > 0.05), but there was no significant difference. c IHC images of human tumor tissue and para-tumor tissue stained with H&E, GRN, PLXNC1 and ORMDL3 antibodies (magnification:200X; scale bar:50 μm). ca: ICC tissues,cap: peritumoral tissues.*P < 0.05, **P < 0.01, ***P < 0.001
    Figure Legend Snippet: a RT-PCR detection showed that the ca group showed high expressions of GRN, PLXNC1 and ORMDL3 compared with the cap group, and the difference between GRN and ORMDL3 was statistically significant (P < 0.05). b WB showed that the expressions of GRN and ORMDL3 were significantly increased in the ca group and the cap group (P < 0.05) and PLXNC1 increased (P > 0.05), but there was no significant difference. c IHC images of human tumor tissue and para-tumor tissue stained with H&E, GRN, PLXNC1 and ORMDL3 antibodies (magnification:200X; scale bar:50 μm). ca: ICC tissues,cap: peritumoral tissues.*P < 0.05, **P < 0.01, ***P < 0.001

    Techniques Used: Reverse Transcription Polymerase Chain Reaction, Staining



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