rabbit anti p erbb4 (Bioss)
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rabbit anti p erbb4
Rabbit Anti P Erbb4, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti p erbb4/product/Bioss
Average 94 stars, based on 4 article reviews
Rabbit Anti P Erbb4, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti p erbb4/product/Bioss
Average 94 stars, based on 4 article reviews
rabbit anti p erbb4 - by Bioz Stars,
2026-02
94/100 stars
Images
1) Product Images from "Targeted ErbB4 receptor activation ameliorates neuronal deficits via DOCK3 signaling in a transgenic mouse AD model"
Article Title: Targeted ErbB4 receptor activation ameliorates neuronal deficits via DOCK3 signaling in a transgenic mouse AD model
Journal: Neurotherapeutics
doi: 10.1016/j.neurot.2025.e00739
Figure Legend Snippet: ErbB4 small molecule agonist ameliorates cognitive behavioral impairments in APP/PS1 mice. (A) Behavioral experimental scheme (D, days following the initiation of the behavioral experiment). (B) Representative traces in open field experiment. (C) The related statistical analysis of in open field experiment. (D) Representative traces in novel object recognition experiment. (E) The related statistical analyses in novel object recognition experiment. (F) Representative heat map in Y maze exploration experiment. (G) The rate of spontaneous alternation in Y maze experiment. (H) Representative swimming traces in water maze exploration experiment. (I) The one-way ANOVA statistical analysis of water maze exploration experiment. Tukey multiple comparative analyses were employed and data were presented as means ± standard error of the mean (SEM). ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001. n = 8 per group.
Techniques Used:
Figure Legend Snippet: ErbB4 small molecule agonist can improve the decrease of dendritic complexity and dendritic spine injury of hippocampal neurons in APP/PS1 mice. (A) Representative images of hippocampal neurons with a scale = 50 μm; (B) dendrite length of hippocampal neurons; (C) The number of branching points of hippocampal neurons; (D) Representative images of neuronal dendritic segments, scale bar = 10 μm; (E) total dendrite spine density of hippocampal neurons; (F) Mushroom spine density of hippocampal neurons. The results were presented as means ± SEM. Significance levels were denoted as ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, with a sample size of n = 4 per group.
Techniques Used:
Figure Legend Snippet: ErbB4 small molecule agonist can improve synaptic dysfunction of hippocampal neurons in APP/PS1 mice. (A) The ultrastructure of hippocampal neuron synapses was examined using transmission electron microscopy. (B) Statistical analysis was conducted on data related to hippocampal neuron synapses. (C) Levels of SYP and β3-tubulin detected by immunofluorescence. (D) Levels of DOCK3 and β3-tubulin detected by immunofluorescence. (E) Protein levels of the synapse-related proteins DOCK3, p -CREB, CREB, SYP, GAP43, PSD95, SYT1 in hippocampal neurons were assessed using Western blot analysis. (F) E statistical analysis was conducted on the data obtained from these protein levels, with Tukey multiple comparative analyses being utilized. Magnification, 10000 × for synaptic structure; scale bar, 1 μm. The results were presented as means ± SEM. SYP: red; DOCK3: red; β3-tubulin: green; scale bar = 20 μm. Significance levels were denoted as ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, with a sample size of n = 4–5 per group.
Techniques Used: Transmission Assay, Electron Microscopy, Immunofluorescence, Western Blot
Figure Legend Snippet: ErbB4 small molecule agonist can improve mitochondrial damage in hippocampal neurons of APP/PS1 mice. (A) The ultrastructure of hippocampal neuron mitochondria was examined using transmission electron microscopy. (B) Statistical analysis was conducted on data related to hippocampal neuron mitochondria. (C) Protein levels of the mitochondria-related proteins SIRT3 in hippocampal neurons were assessed using Western blot analysis. (D) Statistical analysis was conducted on the data obtained from these protein levels. (E) Levels of SIRT3 and β3-tubulin detected by immunofluorescence. SIRT3: red; β3-tubulin: green; scale bar = 20 μm. Tukey multiple comparative analyses were utilized. Magnification, 2000 × for mitochondrial structure; scale bar = 5 μm. The results were presented as means ±SEM. Significance levels were denoted as ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, with a sample size of n = 4–5 per group.
Techniques Used: Transmission Assay, Electron Microscopy, Western Blot, Immunofluorescence
Figure Legend Snippet: ErbB4 small molecule agonist can improve the ErbB4 signaling pathway in hippocampus of APP/PS1 mice. (A) Levels of p -ErbB4 and β3-tubulin detected by immunofluorescence. (B) Protein levels of the ErbB4 pathway proteins in hippocampal neurons were assessed using Western blot analysis. (C) Statistical analysis was conducted on the data obtained from these protein levels, with Tukey multiple comparative analyses being utilized. p -ErbB4: red; β3-tubulin: green; scale bar = 20 μm. The results were presented as means ± SEM, with significance levels denoted as ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001. Each experimental group consisted of n = 5 samples.
Techniques Used: Immunofluorescence, Western Blot
Figure Legend Snippet: ErbB4 small molecule agonist can improve hippocampal neuroinflammation in APP/PS1 mice through TLR4/NLRP3 pathway. (A) Levels of Aβ and IBA1 detected by immunofluorescence staining. (B) Levels of Aβ and GFAP detected by immunofluorescence staining. (C) Western blot analysis was utilized to detect protein levels associated with the TLR4/NLRP3 pathway in microglial cells. (D) Statistical charts were generated to display the protein levels of TLR4/NLRP3. IBA1: red; GFAP: red; Aβ: green; scale bar = 50 μm. Tukey multiple comparative analyses were conducted, with data reported as means ± SEM. Significance levels were denoted as ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. Each group consisted of n = 5 samples.
Techniques Used: Immunofluorescence, Staining, Western Blot, Generated
Figure Legend Snippet: ErbB4 small molecule agonist improves hippocampal neuronal injury in AD pathologic state in vitro through ErbB4 pathway. (A–F) After treatment with Aβ1-42 at 10 μM for 12 h, hippocampal neurons were treated with C11H7BrO3 at a concentration of 10 nM for an additional 24 h. (A) Protein levels of the ErbB4 pathway-related proteins in hippocampal neurons were assessed using Western blot analysis. (B) A statistical representation of these protein levels was generated in a chart. (C) Protein levels of SIRT3, CREB and GAP43 in hippocampal neurons were assessed using Western blot analysis. (D) Statistical representation of these protein levels was generated in a chart. (E) Protein levels of PSD95, SYP, SYT1, and DOCK3 in hippocampal neurons were assessed using Western blot analysis. (F) Statistical representation of these protein levels was generated in a chart. Tukey multiple comparative analyses were conducted, with data reported as means ± SEM. Significance levels were denoted as ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. A minimum sample size of n = 5–6 per group was utilized.
Techniques Used: In Vitro, Concentration Assay, Western Blot, Generated
Figure Legend Snippet: The ErbB4 small molecule agonist modulates DOCK3 to ameliorate hippocampal neuronal injury under AD pathological conditions in vitro. (A–H) After a 12 h exposure to 10 μM Aβ, the cells were transfected with either 50 nM si-NC or si-DOCK3 for 24 h. This was followed by a combined treatment with C11H7BrO3 at a concentration of 10 nM for an additional 24 h. (A) Protein levels of the ErbB4 pathway-related proteins in hippocampal neurons were assessed using Western blot analysis. (B) Statistical representation of these protein levels was generated in a chart. (C) Protein levels of DOCK3, CREB, SIRT3 in hippocampal neurons were assessed using Western blot analysis. (D) Statistical representation of these protein levels was generated in a chart. (E) Protein levels of the synapse proteins SYT1, GAP43, SYP, and PSD95 in hippocampal neurons were assessed using Western blot analysis. (F) Statistical representation of these protein levels was generated in a chart. (G) Levels of oxidative stress indicators in hippocampal neurons, including T-SOD, GSH, GSH-Px, and MDA. (H) Intracellular ATP and extracellular ATP (eATP) levels in hippocampal neurons. (I–J). Representative images and quantitative analysis of mitochondrial signaling and membrane potential in hippocampal neurons. (K) The mitochondrial homeostasis function of hippocampal neurons involved the measurement of Mito-Tracker Green and TMRE levels. Tukey multiple comparative analyses were conducted, with data reported as means ± SEM. Significance levels were denoted as ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. Scale bar = 20 μm. A minimum sample size of n = 5–6 per group was utilized.
Techniques Used: In Vitro, Transfection, Concentration Assay, Western Blot, Generated, Membrane