other:Article Title: Identifying disease-associated pathways in one-phenotype data based on reversal gene expression orderings
Article Snippet: BIOCARTA ACE2 PATHWAY >0.05 >0.05 6.52E-05 2.68E-06 >0.05 >0.05 BIOCARTA AGR PATHWAY 0.006099829 0.038355334 >0.05 >0.05 >0.05 >0.05 BIOCARTA AKAPCENTROSOME PATHWAY >0.05 >0.05 0.036605118 >0.05 0.026263818 >0.05 BIOCARTA AKT PATHWAY 0.047739256 0.010643388 >0.05 >0.05 >0.05 >0.05 BIOCARTA ALK PATHWAY >0.05 >0.05 0.000788454 0.002648737 >0.05 >0.05 BIOCARTA ARF PATHWAY >0.05 >0.05 0.000100371 0.000128387 >0.05 >0.05 BIOCARTA ATRBRCA PATHWAY >0.05 >0.05 0.005064547 >0.05 0.029212858 >0.05 BIOCARTA BIOPEPTIDES PATHWAY >0.05 0.014945857 0.013173435 >0.05 >0.05 >0.05 BIOCARTA CCR5 PATHWAY 0.002457247 >0.05 0.008789742 >0.05 >0.05 >0.05 BIOCARTA CTCF PATHWAY >0.05 >0.05 0.019788138 8.71E-07 >0.05 >0.05 BIOCARTA GH PATHWAY 0.03160415 2.80E-06 >0.05 >0.05 >0.05 >0.05 BIOCARTA GRANULOCYTES PATHWAY >0.05 >0.05 0.033444199 >0.05 8.82E-05 >0.05 BIOCARTA IGF1 PATHWAY 4.38E-06 0.000594464 >0.05 >0.05 >0.05 >0.05 BIOCARTA IL3 PATHWAY 0.039807053 >0.05 0.001796023 >0.05 >0.05 >0.05 BIOCARTA IL7 PATHWAY 0.000191749 4.31E-05 >0.05 >0.05 >0.05 >0.05 BIOCARTA LEPTIN PATHWAY 0.00777392 9.64E-05 >0.05 >0.05 >0.05 >0.05 BIOCARTA LONGEVITY PATHWAY 3.31E-06 3.14E-09 >0.05 >0.05 >0.05 >0.05 BIOCARTA MCM PATHWAY >0.05 0.00013499 0.03640926 >0.05 >0.05 >0.05 BIOCARTA MPR PATHWAY 0.019166836 0.003440915 >0.05 >0.05 >0.05 >0.05 BIOCARTA P38MAPK PATHWAY >0.05 0.020994156 >0.05 >0.05 0.038597433 >0.05 BIOCARTA SET PATHWAY >0.05 >0.05 0.006960476 0.001077033 >0.05 >0.05 BIOCARTA TFF PATHWAY 1.03E-05 0.005063928 >0.05 >0.05 >0.05 >0.05 KEGG ADIPOCYTOKINE SIGNALING PATHWAY 0.000 0.000 >0.05 >0.05 >0.05 >0.05 KEGG APOPTOSIS >0.05 >0.05 0.001548907 0.039787547 >0.05 >0.05
Article Title: Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma.
Article Snippet: BIOCARTA_TID_PATHWAY -0.9214274 0.7453602 BIOCARTA_GLEEVEC_PATHWAY -0.9202868 0.7437639 BIOCARTA_INSULIN_PATHWAY -0.9021251 0.7809233 KEGG_LYSINE_DEGRADATION -0.898462 0.78475714 BIOCARTA_CDMAC_PATHWAY -0.8983203 0.78075856 BIOCARTA_PPARA_PATHWAY 0.87663275 1 KEGG_ADHERENS_JUNCTION -0.87148243 0.83573925 BIOCARTA_EGF_PATHWAY -0.86952966 0.835297 KEGG_BLADDER_CANCER 0.86902344 1 KEGG_PATHWAYS_IN_CANCER 0.862868 1 KEGG_WNT_SIGNALING_PATHWAY -0.8615491 0.84700733 KEGG_GLIOMA 0.860394 1 KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE -0.85661364 0.85253155 BIOCARTA_EIF4_PATHWAY -0.8474534 0.86652565 BIOCARTA_CK1_PATHWAY -0.8404916 0.8754715 BIOCARTA_CALCINEURIN_PATHWAY 0.8281449 1 KEGG_GNRH_SIGNALING_PATHWAY -0.82002115 0.9098307 KEGG_RENAL_CELL_CARCINOMA -0.8086713 0.92594695 BIOCARTA_MTOR_PATHWAY 0.8077915 1 BIOCARTA_BAD_PATHWAY 0.8032015 1 BIOCARTA_CTCF_PATHWAY -0.7870396 0.9580654 KEGG_ASTHMA -0.78573745 0.95520914 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION -0.78565675 0.95033115 BIOCARTA_BCR_PATHWAY -0.7801709 0.9542938 BIOCARTA_CASPASE_PATHWAY -0.77817005 0.95256007 BIOCARTA_AT1R_PATHWAY -0.7773184 0.9489741 KEGG_MTOR_SIGNALING_PATHWAY 0.7758864 1 BIOCARTA_IGF1R_PATHWAY 0.76383954 1 KEGG_VIRAL_MYOCARDITIS 0.75624263 1 BIOCARTA_NFAT_PATHWAY 0.752076 1 KEGG_PROTEASOME 0.7511516 1 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0.7505752 1 KEGG_O_GLYCAN_BIOSYNTHESIS 0.74268 1 BIOCARTA_P38MAPK_PATHWAY -0.7351197 1 BIOCARTA_AGR_PATHWAY -0.7263676 1 BIOCARTA_VIP_PATHWAY -0.7239398 1 KEGG_OXIDATIVE_PHOSPHORYLATION 0.7228392 1 KEGG_ALZHEIMERS_DISEASE -0.7222655 1 KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE 0.7222216 1 KEGG_CITRATE_CYCLE_TCA_CYCLE -0.71837944 1 BIOCARTA_RAS_PATHWAY -0.71357554 1 BIOCARTA_GPCR_PATHWAY -0.7007401 1 BIOCARTA_IL3_PATHWAY -0.6944882 1 KEGG_OLFACTORY_TRANSDUCTION 0.6930238 1 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC -0.69172525 1 BIOCARTA_PYK2_PATHWAY -0.6848684 1 BIOCARTA_WNT_PATHWAY 0.6848396 1 BIOCARTA_DEATH_PATHWAY -0.677364 1 BIOCARTA_TFF_PATHWAY -0.6764886 1 BIOCARTA_HIVNEF_PATHWAY -0.67072845 1 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES -0.66950035 1 KEGG_PARKINSONS_DISEASE -0.6689508 0.99620813 BIOCARTA_MCALPAIN_PATHWAY -0.6623327 0.9960744 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY -0.6603868 0.9925571 BIOCARTA_GATA3_PATHWAY 0.65777916 1 BIOCARTA_UCALPAIN_PATHWAY 0.65528196 1 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0.6552235 1 BIOCARTA_NGF_PATHWAY -0.65180737 0.9932271 Page 59 of 54 Hepatology Hepatology This article is protected by copyright.
Article Title: Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma.
Article Snippet: Hart and Rader, et al. Preclinical therapeutic synergy of MEK1/2 and CDK4/6 inhibition in neuroblastoma Lori S. Hart1+, JulieAnn Rader1+, Pichai Raman1, Vandana Batra1, Mike R. Russell1, Matthew Tsang1, Maria Gagliardi1, Lucy Chen1, Daniel Martinez2, Yimei Li1,3, Andrew Wood1, Sunkyu Kim4, Sudha Parasuraman4, Scott Delach4, Kristina A. Cole1,3, Shiva Krupa5, Markus Boehm5, Malte Peters5, Giordano Caponigro4 and John M. Maris1,3,6,* 1Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia PA, USA.. 2Division of Pathology, Children's Hospital of Philadelphia.. 3Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia PA, USA.
Article Title: Three new circulating microRNAs may be associated with wet age-related macular degeneration.
Article Snippet: This study investigates the circulating microRNA (miRNA) expression profiles in patients with agerelated macular degeneration (AMD) and the role of miRNA in wet AMD and its pathways.. Exosomes were extracted from serum samples of AMD patients (n1⁄4 70) and a control group (n1⁄4 50).. After isolating miRNA from the exosomes, miRNAs were transformed into cDNA.
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