benfotiamine  (MedChemExpress)

Journal: Renal Failure

Article Title: The relationship between thiamin, folic acid and cognitive function in a rat model of uremia

doi: 10.1080/0886022X.2024.2329257

Figure Lengend Snippet: Cell viability and oxidative stress level of LPS-stimulated microglial cells. a, relative cell viability of LPS-stimulated microglial cells pretreated with either benfotiamine or folic acid. ***: p < 0.001. b, 8-OHdG concentration in culture supernatants of LPS-stimulated microglial cells pretreated with either benfotiamine or folic acid. Specific data were shown in Supplementary Table S4 . *: p < 0.05.

Article Snippet: The cells were pretreated with either benfotiamine (50 or 100 μmol/L; MCE, US) for 24 h, or folic acid (5 or 10 ug/mL; MCE, US) for 1 h, and then stimulated with 1 μg/mL LPS (MCE, US) for 24 h.

Techniques: Concentration Assay

Journal: Journal of Molecular Modeling

Article Title: Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein

doi: 10.1007/s00894-022-05138-3

Figure Lengend Snippet: Top screened vitamins against main protease (section I) and RBD domain (section II) of Spike protein

Article Snippet: Benfotiamine may also be beneficial for the treatment and prevention of diabetic nephropathy and type 2 diabetes mellitus [15-Selleckchem].

Techniques:

Journal: Journal of Molecular Modeling

Article Title: Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein

doi: 10.1007/s00894-022-05138-3

Figure Lengend Snippet: Analysis of the molecular dynamics simulations for 3CLpro-ligand and S-RBD-ligand complexes. A Root mean square deviation (RMSD) analysis of the protein backbone for the complexes of 3CLpro-with bentiamine, folic acid, riboflavin, and fursultiamine. B S-RBD-with bentiamine, folic acid, benfotiamine, and vitamin B12. C Root mean square fluctuation (RMSF) plot for the protein backbone atoms for 3CLpro-ligand complexes and D S-RBD-ligand complexes

Article Snippet: Benfotiamine may also be beneficial for the treatment and prevention of diabetic nephropathy and type 2 diabetes mellitus [15-Selleckchem].

Techniques:

Journal: Journal of Molecular Modeling

Article Title: Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein

doi: 10.1007/s00894-022-05138-3

Figure Lengend Snippet: Ligplot analysis of 3CLpro-ligand and S-RBD-ligand interaction. A 2D representation of the hit compounds in the binding pocket of chain A and chain B in the dimeric form of 3CL-protease (6lu7) after molecular dynamics for 3CLpro-bentiamine and 3CLpro-folic acid, 3CLpro-riboflavin, and 3CLpro-fursultiamine. B 2D representation of the hit compounds in the interface area of S-RBD, after molecular dynamics simulation of S-RBD-vitamin B12, folic acid, bentiamine, and benfotiamine. Green lines indicate the hydrogen bonds, and red-dotted lines indicate the hydrophobic interactions (images are drawn for the repeat one of each ligand)

Article Snippet: Benfotiamine may also be beneficial for the treatment and prevention of diabetic nephropathy and type 2 diabetes mellitus [15-Selleckchem].

Techniques: Binding Assay