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astx 660  (MedChemExpress)


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    MedChemExpress astx 660
    Astx 660, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/astx 660/product/MedChemExpress
    Average 93 stars, based on 5 article reviews
    astx 660 - by Bioz Stars, 2026-02
    93/100 stars

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    A Scheme of the skin inflammation model. B Representative images of skin lesions from mice 4 days after injection with vehicle control ( n = 9), <t>ASTX660</t> and Emricasan (A/E) ( n = 7) or EGF application with ASTX660 and Emricasan (EGF + A/E) ( n = 7) ( C ) Representative images of lesions treated as in ( A ) and stained with H&E, performing a TUNEL assay and immunostained with anti-CD3 and anti-CD11b antibodies. D Histological multivariate lesion score (HLS) of mice treated as described in ( A ). E Percentage contribution of ulcers and loss of epidermis in each mouse. F Percentage contribution of deep ulceration in each mouse. G The skins were lysed using lysis buffer and a homogeniser, followed by immunoblotting analysis using the indicated antibodies. Data are the mean ± standard deviation (S.D.), vehicle ( n = 9), A/E ( n = 7), A/E + EGF ( n = 7) with ns non-significance, * P < 0.05, ** P < 0.01 and *** P < 0.001 at each point compared to the indicated graph with the two-sided Student’s t test ( D , E , F ).
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    A Scheme of the skin inflammation model. B Representative images of skin lesions from mice 4 days after injection with vehicle control ( n = 9), <t>ASTX660</t> and Emricasan (A/E) ( n = 7) or EGF application with ASTX660 and Emricasan (EGF + A/E) ( n = 7) ( C ) Representative images of lesions treated as in ( A ) and stained with H&E, performing a TUNEL assay and immunostained with anti-CD3 and anti-CD11b antibodies. D Histological multivariate lesion score (HLS) of mice treated as described in ( A ). E Percentage contribution of ulcers and loss of epidermis in each mouse. F Percentage contribution of deep ulceration in each mouse. G The skins were lysed using lysis buffer and a homogeniser, followed by immunoblotting analysis using the indicated antibodies. Data are the mean ± standard deviation (S.D.), vehicle ( n = 9), A/E ( n = 7), A/E + EGF ( n = 7) with ns non-significance, * P < 0.05, ** P < 0.01 and *** P < 0.001 at each point compared to the indicated graph with the two-sided Student’s t test ( D , E , F ).
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    A Scheme of the skin inflammation model. B Representative images of skin lesions from mice 4 days after injection with vehicle control ( n = 9), <t>ASTX660</t> and Emricasan (A/E) ( n = 7) or EGF application with ASTX660 and Emricasan (EGF + A/E) ( n = 7) ( C ) Representative images of lesions treated as in ( A ) and stained with H&E, performing a TUNEL assay and immunostained with anti-CD3 and anti-CD11b antibodies. D Histological multivariate lesion score (HLS) of mice treated as described in ( A ). E Percentage contribution of ulcers and loss of epidermis in each mouse. F Percentage contribution of deep ulceration in each mouse. G The skins were lysed using lysis buffer and a homogeniser, followed by immunoblotting analysis using the indicated antibodies. Data are the mean ± standard deviation (S.D.), vehicle ( n = 9), A/E ( n = 7), A/E + EGF ( n = 7) with ns non-significance, * P < 0.05, ** P < 0.01 and *** P < 0.001 at each point compared to the indicated graph with the two-sided Student’s t test ( D , E , F ).
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    Image Search Results


    A Scheme of the skin inflammation model. B Representative images of skin lesions from mice 4 days after injection with vehicle control ( n = 9), ASTX660 and Emricasan (A/E) ( n = 7) or EGF application with ASTX660 and Emricasan (EGF + A/E) ( n = 7) ( C ) Representative images of lesions treated as in ( A ) and stained with H&E, performing a TUNEL assay and immunostained with anti-CD3 and anti-CD11b antibodies. D Histological multivariate lesion score (HLS) of mice treated as described in ( A ). E Percentage contribution of ulcers and loss of epidermis in each mouse. F Percentage contribution of deep ulceration in each mouse. G The skins were lysed using lysis buffer and a homogeniser, followed by immunoblotting analysis using the indicated antibodies. Data are the mean ± standard deviation (S.D.), vehicle ( n = 9), A/E ( n = 7), A/E + EGF ( n = 7) with ns non-significance, * P < 0.05, ** P < 0.01 and *** P < 0.001 at each point compared to the indicated graph with the two-sided Student’s t test ( D , E , F ).

    Journal: Cell Death and Differentiation

    Article Title: EGFR inhibits TNF-α-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401

    doi: 10.1038/s41418-024-01316-3

    Figure Lengend Snippet: A Scheme of the skin inflammation model. B Representative images of skin lesions from mice 4 days after injection with vehicle control ( n = 9), ASTX660 and Emricasan (A/E) ( n = 7) or EGF application with ASTX660 and Emricasan (EGF + A/E) ( n = 7) ( C ) Representative images of lesions treated as in ( A ) and stained with H&E, performing a TUNEL assay and immunostained with anti-CD3 and anti-CD11b antibodies. D Histological multivariate lesion score (HLS) of mice treated as described in ( A ). E Percentage contribution of ulcers and loss of epidermis in each mouse. F Percentage contribution of deep ulceration in each mouse. G The skins were lysed using lysis buffer and a homogeniser, followed by immunoblotting analysis using the indicated antibodies. Data are the mean ± standard deviation (S.D.), vehicle ( n = 9), A/E ( n = 7), A/E + EGF ( n = 7) with ns non-significance, * P < 0.05, ** P < 0.01 and *** P < 0.001 at each point compared to the indicated graph with the two-sided Student’s t test ( D , E , F ).

    Article Snippet: We incorporated 3 μM ASTX660 (Selleck, S8681-5 mg) and 3 μM Emricasan (Sigma Aldrich, SML2227) into 100 μL of 10% Captisol (Selleck, S4592).

    Techniques: Injection, Control, Staining, TUNEL Assay, Lysis, Western Blot, Standard Deviation