astemizole (Tocris)
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Tocris
astemizole
Astemizole, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/astemizole/Astemizole/10__1093_slash_rpsppr_slash_rqaf014-44-82-84
Average 93 stars, based on 13 article reviews
Astemizole, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/astemizole/Astemizole/10__1093_slash_rpsppr_slash_rqaf014-44-82-84
Average 93 stars, based on 13 article reviews
astemizole - by Bioz Stars,
2026-09
93/100 stars
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Positive Control:Article Title: Identification of novel EED-EZH2 PPI inhibitors using an in silico fragment mapping method. Article Snippet: Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase that is overexpressed in many cancers.. Numerous EZH2 inhibitors have been developed as anticancer agents, but recent studies have also focused on protein–protein interaction (PPI) between embryonic ectoderm development (EED) and EZH2 as a novel drug discovery target.. Because EED indirectly enhances EZH2 enzymatic activity, EED-EZH2 PPI inhibitors suppress the methyltransferase activity and inhibit cancer growth. Comparison:Article Title: Identification of novel EED-EZH2 PPI inhibitors using an in silico fragment mapping method. Article Snippet: Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase that is overexpressed in many cancers.. Numerous EZH2 inhibitors have been developed as anticancer agents, but recent studies have also focused on protein–protein interaction (PPI) between embryonic ectoderm development (EED) and EZH2 as a novel drug discovery target.. Because EED indirectly enhances EZH2 enzymatic activity, EED-EZH2 PPI inhibitors suppress the methyltransferase activity and inhibit cancer growth. Saline:Article Title: An Investigation of Lysosome-Dependent Cell Death in Breast Cancer Cells Treated with Doxorubicin Article Snippet: 3.2.4 MATERIALS AND METHODS 3.2.4.1 Materials Trypsin/ EDTA buffer solution, penicillin and streptomycin antibiotic solutions, dimethyl sulfoxide (DMSO), EDTA, DL-Diothiothreitol (DTT) solution, glycerol, HEPES solution (1 M, pH 7.0-7.6), Triton X-100 (TX-100), hydrogen peroxide solution (30% w/w in water), and E64 protease inhibitor (EMD Millipore) were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), trypan blue (Corning), Countess cell counter chamber slides (anitrogen), MTT (3-(4,5-Dimethylthiazol-2-yl)—2,5- Diphenyltetrazolium Bromide, Invitrogen), CTSB substrate 111 (Z-Arg-Arg-AMC, EMD Millipore), CellEventTMCaspase-3/7 green flow cytometry assay kit (Invitrogen), RPMI 1640 (Coming), staurosporine (STS, Enzo Life Sciences), and Article Title: Lysosome-mediated cytotoxicity in breast cancer subtype cells treated with doxorubicin Article Snippet: Dimethyl sulphoxide (DMSO), hydrogen peroxide (H2O2, 30% w/v), E64 cysteine protease inhibitor (EMD Millipore), and MDA-MB-231 cells were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), trypsin/EDTA, penicillin/streptomycin, fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT, Invitrogen), LysoTracker Green DND-26 (LTG, Molecular Probes), JC-1 assay kit (Molecular Probes), Hoechst 33342 (20 mM, Thermo Scientific), poly-L-lysine coated glass coverslips (NeuVitro), 10 kDa AlexaFluor488 dextran (Invitrogen), CTSB substrate III (Z-Arg-ArgAMC, EMD Millipore), H2DCFDA/DCFDA (Invitrogen), pifithrin-α (PFT-α, EMD Millipore), tiron (Thermo Scientific), trypan blue (0.4% w/v, Corning), Countess chamber slides (Invitrogen), RPMI 1640 (Corning), staurosporine (STS, Enzo Life Sciences), and Recombinant:Article Title: An Investigation of Lysosome-Dependent Cell Death in Breast Cancer Cells Treated with Doxorubicin Article Snippet: 3.2.4 MATERIALS AND METHODS 3.2.4.1 Materials Trypsin/ EDTA buffer solution, penicillin and streptomycin antibiotic solutions, dimethyl sulfoxide (DMSO), EDTA, DL-Diothiothreitol (DTT) solution, glycerol, HEPES solution (1 M, pH 7.0-7.6), Triton X-100 (TX-100), hydrogen peroxide solution (30% w/w in water), and E64 protease inhibitor (EMD Millipore) were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), trypan blue (Corning), Countess cell counter chamber slides (anitrogen), MTT (3-(4,5-Dimethylthiazol-2-yl)—2,5- Diphenyltetrazolium Bromide, Invitrogen), CTSB substrate 111 (Z-Arg-Arg-AMC, EMD Millipore), CellEventTMCaspase-3/7 green flow cytometry assay kit (Invitrogen), RPMI 1640 (Coming), staurosporine (STS, Enzo Life Sciences), and Article Title: Lysosome-mediated cytotoxicity in breast cancer subtype cells treated with doxorubicin Article Snippet: Dimethyl sulphoxide (DMSO), hydrogen peroxide (H2O2, 30% w/v), E64 cysteine protease inhibitor (EMD Millipore), and MDA-MB-231 cells were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), trypsin/EDTA, penicillin/streptomycin, fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT, Invitrogen), LysoTracker Green DND-26 (LTG, Molecular Probes), JC-1 assay kit (Molecular Probes), Hoechst 33342 (20 mM, Thermo Scientific), poly-L-lysine coated glass coverslips (NeuVitro), 10 kDa AlexaFluor488 dextran (Invitrogen), CTSB substrate III (Z-Arg-ArgAMC, EMD Millipore), H2DCFDA/DCFDA (Invitrogen), pifithrin-α (PFT-α, EMD Millipore), tiron (Thermo Scientific), trypan blue (0.4% w/v, Corning), Countess chamber slides (Invitrogen), RPMI 1640 (Corning), staurosporine (STS, Enzo Life Sciences), and MTT Assay:Article Title: An Investigation of Lysosome-Dependent Cell Death in Breast Cancer Cells Treated with Doxorubicin Article Snippet: 3.2.4 MATERIALS AND METHODS 3.2.4.1 Materials Trypsin/ EDTA buffer solution, penicillin and streptomycin antibiotic solutions, dimethyl sulfoxide (DMSO), EDTA, DL-Diothiothreitol (DTT) solution, glycerol, HEPES solution (1 M, pH 7.0-7.6), Triton X-100 (TX-100), hydrogen peroxide solution (30% w/w in water), and E64 protease inhibitor (EMD Millipore) were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), trypan blue (Corning), Countess cell counter chamber slides (anitrogen), MTT (3-(4,5-Dimethylthiazol-2-yl)—2,5- Diphenyltetrazolium Bromide, Invitrogen), CTSB substrate 111 (Z-Arg-Arg-AMC, EMD Millipore), CellEventTMCaspase-3/7 green flow cytometry assay kit (Invitrogen), RPMI 1640 (Coming), staurosporine (STS, Enzo Life Sciences), and Article Title: Lysosome-mediated cytotoxicity in breast cancer subtype cells treated with doxorubicin Article Snippet: Dimethyl sulphoxide (DMSO), hydrogen peroxide (H2O2, 30% w/v), E64 cysteine protease inhibitor (EMD Millipore), and MDA-MB-231 cells were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), trypsin/EDTA, penicillin/streptomycin, fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT, Invitrogen), LysoTracker Green DND-26 (LTG, Molecular Probes), JC-1 assay kit (Molecular Probes), Hoechst 33342 (20 mM, Thermo Scientific), poly-L-lysine coated glass coverslips (NeuVitro), 10 kDa AlexaFluor488 dextran (Invitrogen), CTSB substrate III (Z-Arg-ArgAMC, EMD Millipore), H2DCFDA/DCFDA (Invitrogen), pifithrin-α (PFT-α, EMD Millipore), tiron (Thermo Scientific), trypan blue (0.4% w/v, Corning), Countess chamber slides (Invitrogen), RPMI 1640 (Corning), staurosporine (STS, Enzo Life Sciences), and Flow Cytometry:Article Title: An Investigation of Lysosome-Dependent Cell Death in Breast Cancer Cells Treated with Doxorubicin Article Snippet: 3.2.4 MATERIALS AND METHODS 3.2.4.1 Materials Trypsin/ EDTA buffer solution, penicillin and streptomycin antibiotic solutions, dimethyl sulfoxide (DMSO), EDTA, DL-Diothiothreitol (DTT) solution, glycerol, HEPES solution (1 M, pH 7.0-7.6), Triton X-100 (TX-100), hydrogen peroxide solution (30% w/w in water), and E64 protease inhibitor (EMD Millipore) were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), trypan blue (Corning), Countess cell counter chamber slides (anitrogen), MTT (3-(4,5-Dimethylthiazol-2-yl)—2,5- Diphenyltetrazolium Bromide, Invitrogen), CTSB substrate 111 (Z-Arg-Arg-AMC, EMD Millipore), CellEventTMCaspase-3/7 green flow cytometry assay kit (Invitrogen), RPMI 1640 (Coming), staurosporine (STS, Enzo Life Sciences), and AST Assay:Article Title: An Investigation of Lysosome-Dependent Cell Death in Breast Cancer Cells Treated with Doxorubicin Article Snippet: 3.2.4 MATERIALS AND METHODS 3.2.4.1 Materials Trypsin/ EDTA buffer solution, penicillin and streptomycin antibiotic solutions, dimethyl sulfoxide (DMSO), EDTA, DL-Diothiothreitol (DTT) solution, glycerol, HEPES solution (1 M, pH 7.0-7.6), Triton X-100 (TX-100), hydrogen peroxide solution (30% w/w in water), and E64 protease inhibitor (EMD Millipore) were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), trypan blue (Corning), Countess cell counter chamber slides (anitrogen), MTT (3-(4,5-Dimethylthiazol-2-yl)—2,5- Diphenyltetrazolium Bromide, Invitrogen), CTSB substrate 111 (Z-Arg-Arg-AMC, EMD Millipore), CellEventTMCaspase-3/7 green flow cytometry assay kit (Invitrogen), RPMI 1640 (Coming), staurosporine (STS, Enzo Life Sciences), and Article Title: Lysosome-mediated cytotoxicity in breast cancer subtype cells treated with doxorubicin Article Snippet: Dimethyl sulphoxide (DMSO), hydrogen peroxide (H2O2, 30% w/v), E64 cysteine protease inhibitor (EMD Millipore), and MDA-MB-231 cells were purchased from Sigma-Aldrich (St. Louis, MO). .. Dulbecco’s phosphate buffered saline (DPBS, Gibco), trypsin/EDTA, penicillin/streptomycin, fetal bovine serum (FBS, Gibco), recombinant human insulin (Santa Cruz), 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT, Invitrogen), LysoTracker Green DND-26 (LTG, Molecular Probes), JC-1 assay kit (Molecular Probes), Hoechst 33342 (20 mM, Thermo Scientific), poly-L-lysine coated glass coverslips (NeuVitro), 10 kDa AlexaFluor488 dextran (Invitrogen), CTSB substrate III (Z-Arg-ArgAMC, EMD Millipore), H2DCFDA/DCFDA (Invitrogen), pifithrin-α (PFT-α, EMD Millipore), tiron (Thermo Scientific), trypan blue (0.4% w/v, Corning), Countess chamber slides (Invitrogen), RPMI 1640 (Corning), staurosporine (STS, Enzo Life Sciences), and other:Article Title: Migraine-provoking substances evoke periorbital allodynia in mice Article Snippet: CGRP, amylin, PACAP, VIP, PGF 2α , olcegepant, astemizole, ER819762 and |
