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KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivation 
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RNF20 regulates RNA polymerase II occupancy on RTA promoter during lytic reactivation of KSHV. (A–D) iBCBL1-3xFLAG-RTA cells were transduced with lenti-shControl or lenti-shRNF20 then reactivated for 12 h, and ChIP-qPCR analysis was performed at the indicated sites of the RTA promoter and gene body. (A) <t>H2BK120ub</t> ChIP. (B) H3K4me3 ChIP. (C) RNA polymerase II (RNAP II) ChIP. (D) ChIP for RNAP II Serine 2 phosphorylation. The degree of statistical significance calculated by t-tests is indicated as *P ≤ 0.05 (n = 3).
KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivation Journal of Virology, 2023 Nov 01
"RNF20 regulates RNA polymerase II occupancy on RTA promoter during lytic reactivation of KSHV. (A–D) iBCBL1-3xFLAG-RTA cells were transduced with lenti-shControl or lenti-shRNF20 then reactivated for 12 h, and ChIP-qPCR analysis was performed at the indicated sites of the RTA promoter and gene body. (A) <t>H2BK120ub</t> ChIP. (B) H3K4me3 ChIP. (C) RNA polymerase II (RNAP II) ChIP. (D) ChIP for RNAP II Serine 2 phosphorylation. The degree of statistical significance calculated by t-tests is indicated as *P ≤ 0.05 (n = 3). "
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