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ATCC an3ca
An3ca, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 393 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/an3ca/product/ATCC
Average 96 stars, based on 393 article reviews

an3ca - by Bioz Stars, 2026-03

96/100 stars

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Prognostic and dysregulated factors in UCEC. In total, 77 prognostic factors for UCEC were overlapped in HPA (n=204) and UALCAN (n=3,600) (A), among which, 49 prognostic factors were further overlapped with ENCORI (B). Afterwards, the prognostic factors with the corresponding up- or down-regulation of expression in UCEC were analyzed by ENCORI (n=14) and UALCAN (n=15), noteworthily, 12 prognostic factors were overlapped (C), among which, there were ten unfavorable factors with upregulated levels and two favorable factors with downregulated levels (D). (E) The heatmap of the 12 overlapped factors in UCEC was exhibited by UALCAN. ENCORI, Encyclopedia of RNA Interactomes; HPA, Human Protein Atlas; TPM, transcripts per million; UALCAN, The University of ALabama at Birmingham CANcer data analysis Portal; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: Prognostic and dysregulated factors in UCEC. In total, 77 prognostic factors for UCEC were overlapped in HPA (n=204) and UALCAN (n=3,600) (A), among which, 49 prognostic factors were further overlapped with ENCORI (B). Afterwards, the prognostic factors with the corresponding up- or down-regulation of expression in UCEC were analyzed by ENCORI (n=14) and UALCAN (n=15), noteworthily, 12 prognostic factors were overlapped (C), among which, there were ten unfavorable factors with upregulated levels and two favorable factors with downregulated levels (D). (E) The heatmap of the 12 overlapped factors in UCEC was exhibited by UALCAN. ENCORI, Encyclopedia of RNA Interactomes; HPA, Human Protein Atlas; TPM, transcripts per million; UALCAN, The University of ALabama at Birmingham CANcer data analysis Portal; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Expressing

CDH18, SHISA9, SNX24, and STX1A might be potential prognostic markers for UCEC exhibited by HPA. HPA database demonstrated that patients with high expression of CDH18 (A,B), SHISA9 (C,D), SNX24 (E,F), and STX1A (G,H) in UCEC possessed poor OS. HPA, Human Protein Atlas; OS, overall survival; TCGA, The Cancer Genome Atlas; TPM, transcripts per million; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: CDH18, SHISA9, SNX24, and STX1A might be potential prognostic markers for UCEC exhibited by HPA. HPA database demonstrated that patients with high expression of CDH18 (A,B), SHISA9 (C,D), SNX24 (E,F), and STX1A (G,H) in UCEC possessed poor OS. HPA, Human Protein Atlas; OS, overall survival; TCGA, The Cancer Genome Atlas; TPM, transcripts per million; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Expressing

CDH18, SHISA9, SNX24, and STX1A might be potential prognostic markers for UCEC exhibited by UALCAN. UALCAN database revealed that patients with high expression of CDH18 (A,B), SHISA9 (C,D), SNX24 (E,F), and STX1A (G,H) in UCEC possessed poor OS. OS, overall survival; TCGA, The Cancer Genome Atlas; UALCAN, The University of ALabama at Birmingham CANcer data analysis Portal; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: CDH18, SHISA9, SNX24, and STX1A might be potential prognostic markers for UCEC exhibited by UALCAN. UALCAN database revealed that patients with high expression of CDH18 (A,B), SHISA9 (C,D), SNX24 (E,F), and STX1A (G,H) in UCEC possessed poor OS. OS, overall survival; TCGA, The Cancer Genome Atlas; UALCAN, The University of ALabama at Birmingham CANcer data analysis Portal; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Expressing

CDH18, SHISA9, SNX24, and STX1A might be potential prognostic markers for UCEC exhibited by ENCORI. ENCORI database displayed that patients with high expression of CDH18 (A,B), SHISA9 (C,D), SNX24 (E,F), and STX1A (G,H) in UCEC possessed poor OS. ENCORI, Encyclopedia of RNA Interactomes; OS, overall survival; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: CDH18, SHISA9, SNX24, and STX1A might be potential prognostic markers for UCEC exhibited by ENCORI. ENCORI database displayed that patients with high expression of CDH18 (A,B), SHISA9 (C,D), SNX24 (E,F), and STX1A (G,H) in UCEC possessed poor OS. ENCORI, Encyclopedia of RNA Interactomes; OS, overall survival; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Expressing

Protein expression of SNX24 in UCEC. HPA exerted that CDH18 did not possess high expression in EC or UCEC cell lines (A,B); SHISA9 exhibited “Pending cancer tissue analysis” (not shown), and no expression in the UCEC cell lines (C); SNX24 possessed high expression in EC as well as UCEC cell lines (D,E); STX1A possessed high expression in EC, but not UCEC cell lines (F,G). EC, endometrial carcinoma; HPA, Human Protein Atlas; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: Protein expression of SNX24 in UCEC. HPA exerted that CDH18 did not possess high expression in EC or UCEC cell lines (A,B); SHISA9 exhibited “Pending cancer tissue analysis” (not shown), and no expression in the UCEC cell lines (C); SNX24 possessed high expression in EC as well as UCEC cell lines (D,E); STX1A possessed high expression in EC, but not UCEC cell lines (F,G). EC, endometrial carcinoma; HPA, Human Protein Atlas; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Expressing

Association between SNX24 expression and multiple clinicopathological features in UCEC. (A) UALCAN database showed that SNX24 exhibited differential expression in up to 16 cancers, including upregulated expression in 10 tumor types, such as UCEC. (B) Based on the TCGA-UCEC data, stage I–IV UCEC patients possessed higher expression of SNX24 compared to normal people, and SNX24 was upregulated with increasing tumor staging grade; (C) endometrioid, serous, and mixed serous-endometrioid UCEC patients possessed higher expression of SNX24 compared to normal people; (D) SNX24 protein at all menopausal status were higher than normal; (E) older UCEC patients possessed higher expression of SNX24 compared to normal people, SNX24 was upregulated with increasing age. TCGA, The Cancer Genome Atlas; TPM, transcripts per million; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: Association between SNX24 expression and multiple clinicopathological features in UCEC. (A) UALCAN database showed that SNX24 exhibited differential expression in up to 16 cancers, including upregulated expression in 10 tumor types, such as UCEC. (B) Based on the TCGA-UCEC data, stage I–IV UCEC patients possessed higher expression of SNX24 compared to normal people, and SNX24 was upregulated with increasing tumor staging grade; (C) endometrioid, serous, and mixed serous-endometrioid UCEC patients possessed higher expression of SNX24 compared to normal people; (D) SNX24 protein at all menopausal status were higher than normal; (E) older UCEC patients possessed higher expression of SNX24 compared to normal people, SNX24 was upregulated with increasing age. TCGA, The Cancer Genome Atlas; TPM, transcripts per million; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Expressing, Quantitative Proteomics

Interaction between SNX24 and CSNK1A1/CSNK1E. (A) Immunohistochemistry staining of SNX24 in UCEC patients based on HPA showed an upregulation of SNX24 protein expression in UCEC tissues (image available from https://www.proteinatlas.org/ENSG00000064652-SNX24/cancer/endometrial+cancer#img ). (B) The consensus of online databases including BioGrid, BioPlex and OpenCell, indicated that CSNK1A1 and CSNK1E could interact with SNX24. Moreover, immunohistochemistry staining of CSNK1A1 and CSNK1E in UCEC patients based on HPA showed an upregulation of CSNK1A1 (image available from https://www.proteinatlas.org/ENSG00000113712-CSNK1A1/cancer/endometrial+cancer#img ) (C) and CSNK1E (image available from https://www.proteinatlas.org/ENSG00000213923-CSNK1E/cancer/endometrial+cancer#img ) (D) in UCEC tissues. EC, endometrial carcinoma; HPA, Human Protein Atlas; IHC, immunohistochemistry; NC, negative control; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: Interaction between SNX24 and CSNK1A1/CSNK1E. (A) Immunohistochemistry staining of SNX24 in UCEC patients based on HPA showed an upregulation of SNX24 protein expression in UCEC tissues (image available from https://www.proteinatlas.org/ENSG00000064652-SNX24/cancer/endometrial+cancer#img ). (B) The consensus of online databases including BioGrid, BioPlex and OpenCell, indicated that CSNK1A1 and CSNK1E could interact with SNX24. Moreover, immunohistochemistry staining of CSNK1A1 and CSNK1E in UCEC patients based on HPA showed an upregulation of CSNK1A1 (image available from https://www.proteinatlas.org/ENSG00000113712-CSNK1A1/cancer/endometrial+cancer#img ) (C) and CSNK1E (image available from https://www.proteinatlas.org/ENSG00000213923-CSNK1E/cancer/endometrial+cancer#img ) (D) in UCEC tissues. EC, endometrial carcinoma; HPA, Human Protein Atlas; IHC, immunohistochemistry; NC, negative control; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Immunohistochemistry, Staining, Expressing, Negative Control

SNX24 was upregulated in UCEC cells. Compared with EM, the mRNA and protein levels of SNX24 were upregulated in AN3-CA cells (A-C), which were inhibited by sh-SNX24 (D-F). **, P<0.01; ***, P<0.001. EM, benign endometrial epithelial cells; NC, negative control; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: SNX24 was upregulated in UCEC cells. Compared with EM, the mRNA and protein levels of SNX24 were upregulated in AN3-CA cells (A-C), which were inhibited by sh-SNX24 (D-F). **, P<0.01; ***, P<0.001. EM, benign endometrial epithelial cells; NC, negative control; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Negative Control

Inhibition of SNX24 impeded the proliferation and invasion of UCEC cells. by downregulation of CSNK1A1 and CSNK1E. The suppression of SNX24 significantly impeded the proliferation (A) and invasion (B,C) of AN3-CA cells (crystal violet, ×200). Suppression of SNX24 significantly inhibited the mRNA and protein expressions of CSNK1A1 and CSNK1E in AN3-CA cells (D-F). *, P<0.05; **, P<0.01; ***, P<0.001. NC, negative control; OD, optical density; UCEC, uterine corpus endometrial carcinoma.

Journal: Translational Cancer Research

Article Title: SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations

doi: 10.21037/tcr-2025-1345

Figure Lengend Snippet: Inhibition of SNX24 impeded the proliferation and invasion of UCEC cells. by downregulation of CSNK1A1 and CSNK1E. The suppression of SNX24 significantly impeded the proliferation (A) and invasion (B,C) of AN3-CA cells (crystal violet, ×200). Suppression of SNX24 significantly inhibited the mRNA and protein expressions of CSNK1A1 and CSNK1E in AN3-CA cells (D-F). *, P<0.05; **, P<0.01; ***, P<0.001. NC, negative control; OD, optical density; UCEC, uterine corpus endometrial carcinoma.

Article Snippet: UCEC cell line AN3-CA (Cat no. HTB-111) was obtained from the American Type Culture Collection (Manassas, VA, USA).

Techniques: Inhibition, Negative Control

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