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amz30  (MedChemExpress)


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    MedChemExpress amz30
    LCMT-1 overexpression or PME-1 inhibition by <t>AMZ30</t> protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).
    Amz30, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/amz30/pmc06008559-41-7-11?v=MedChemExpress
    Average 90 stars, based on 1 article reviews
    amz30 - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein"

    Article Title: Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

    Journal: Frontiers in Aging Neuroscience

    doi: 10.3389/fnagi.2018.00173

    LCMT-1 overexpression or PME-1 inhibition by AMZ30 protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).
    Figure Legend Snippet: LCMT-1 overexpression or PME-1 inhibition by AMZ30 protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).

    Techniques Used: Over Expression, Inhibition, Western Blot, Plasmid Preparation, Control, Activity Assay, CCK-8 Assay



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    LCMT-1 overexpression or PME-1 inhibition by <t>AMZ30</t> protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).
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    LCMT-1 overexpression or PME-1 inhibition by <t>AMZ30</t> protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).
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    LCMT-1 overexpression or PME-1 inhibition by <t>AMZ30</t> protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).
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    Image Search Results


    LCMT-1 overexpression or PME-1 inhibition by AMZ30 protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).

    Journal: Frontiers in Aging Neuroscience

    Article Title: Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

    doi: 10.3389/fnagi.2018.00173

    Figure Lengend Snippet: LCMT-1 overexpression or PME-1 inhibition by AMZ30 protected against PP2A inactivation and cell apoptosis mediated by α-syn. (A,B) Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p -α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn + LCMT-1, α-syn + AMZ30, α-syn + PP2Ac, and α-syn + siPME-1 group. β-tubulin was used as a loading control. The ratio of deMe-PP2A to total-PP2A, total-PP2A to β-tubulin, p -α-syn to β-tubulin in vector group was individually considered as 100%. (C) Histogram showing the PP2A activity in the aforementioned groups. (D) Cell viability was measured with CCK-8. Data are expressed as mean ± SD. KS test; P > 0.05; Brown–Forsythe test; P > 0.05; one-way analysis of variance; ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.01, ∗∗∗∗ P < 0.0001 vs. vector ( n = 3); # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 vs. α-syn ( n = 3).

    Article Snippet: The inhibitor of protein phosphatase methylesterase-1 (PME-1), AMZ30, was purchased from MedChem Express (Shanghai, China).

    Techniques: Over Expression, Inhibition, Western Blot, Plasmid Preparation, Control, Activity Assay, CCK-8 Assay