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recombinant alvac  (Sanofi)

 
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    Sanofi recombinant alvac
    a Heatmap summarizing the significant two-tailed Spearman correlations between the absolute levels (pg/ml) of epidermal growth factor (EGF), Interleukin 17 F (IL-17F), C-C motif chemokine ligand 8 (CCL8), C-X-C motif chemokine ligand 8 (CXCL8), and lymphotoxin-alpha (LTA) measured in plasma collected at week 12 + 24 h from ALFQA ( n = 12) and alum ( n = 17) animals, and at week 13 from ALFQA ( n = 12) and alum ( n = 12) animals, and time of acquisition (TOA). The ρ-values are identified by the color-scale, while the significant correlations ( p < 0.05) are identified by asterisks. Reported p values are unadjusted for multiple comparisons. b , c Correlation of the absolute level (pg/ml) of plasma LTA at week 13 with b TOA in ALFQA ( n = 12) or alum ( n = 12) animals or c the vaccine-induced change (week 13 – baseline) of the frequency of rectal DC-10 in ALFQA ( n = 12) animals (paired data not available in alum-treated animals). d Correlations of the absolute level (pg/ml) of plasma CCL8 at week 12 + 24 h with TOA in alum ( n = 17) and ALFQA ( n = 12) animals. e Schematic representation of immune responses contributing to vaccine efficacy at the systemic and mucosal levels and their comparison between ALFQA (left) and Alum (right) groups. In peripheral blood, the immunization with <t>ΔV1DNA/ALVAC</t> and ΔV1gp120 protein boost adjuvanted in ALFQA induces antibodies to gp120 mediating ADCC, and, when compared to Alum, higher ADCP and ADNP, together with higher CD14 + efferocytes. In the ALFQA group, vaccination induces higher levels of LTA and other cytokines/chemokines. LTA in plasma induces mucosal tolerogenic DC-10, toward a protective phenotype. Together with increased anti-inflammatory CD73 + CD163 + macrophages and ILCs that express NKp44 + and maintain tissue-homeostasis, DC-10 favors the killing and clearance of SIV-infected apoptotic cells, preventing the recruitment of CD4 + target T cells. The figure contains images (monkeys and immunogens) created in BioRender. Woode, E. (2025) https://BioRender.com/p4mqsnf . Correlations: b – d two-tailed Spearman correlation with simple linear regression. Alum animals and correlations are depicted in blue, ALFQA animals and correlations are depicted in red. Source data are provided as a Source Data file.
    Recombinant Alvac, supplied by Sanofi, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/alvac/alvac+recombinant/pmc12480912-282-21-30
    Average 86 stars, based on 1 article reviews
    recombinant alvac - by Bioz Stars, 2026-10
    86/100 stars

    Images

    1) Product Images from "HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques"

    Article Title: HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques

    Journal: Nature Communications

    doi: 10.1038/s41467-025-63610-z

    a Heatmap summarizing the significant two-tailed Spearman correlations between the absolute levels (pg/ml) of epidermal growth factor (EGF), Interleukin 17 F (IL-17F), C-C motif chemokine ligand 8 (CCL8), C-X-C motif chemokine ligand 8 (CXCL8), and lymphotoxin-alpha (LTA) measured in plasma collected at week 12 + 24 h from ALFQA ( n = 12) and alum ( n = 17) animals, and at week 13 from ALFQA ( n = 12) and alum ( n = 12) animals, and time of acquisition (TOA). The ρ-values are identified by the color-scale, while the significant correlations ( p < 0.05) are identified by asterisks. Reported p values are unadjusted for multiple comparisons. b , c Correlation of the absolute level (pg/ml) of plasma LTA at week 13 with b TOA in ALFQA ( n = 12) or alum ( n = 12) animals or c the vaccine-induced change (week 13 – baseline) of the frequency of rectal DC-10 in ALFQA ( n = 12) animals (paired data not available in alum-treated animals). d Correlations of the absolute level (pg/ml) of plasma CCL8 at week 12 + 24 h with TOA in alum ( n = 17) and ALFQA ( n = 12) animals. e Schematic representation of immune responses contributing to vaccine efficacy at the systemic and mucosal levels and their comparison between ALFQA (left) and Alum (right) groups. In peripheral blood, the immunization with ΔV1DNA/ALVAC and ΔV1gp120 protein boost adjuvanted in ALFQA induces antibodies to gp120 mediating ADCC, and, when compared to Alum, higher ADCP and ADNP, together with higher CD14 + efferocytes. In the ALFQA group, vaccination induces higher levels of LTA and other cytokines/chemokines. LTA in plasma induces mucosal tolerogenic DC-10, toward a protective phenotype. Together with increased anti-inflammatory CD73 + CD163 + macrophages and ILCs that express NKp44 + and maintain tissue-homeostasis, DC-10 favors the killing and clearance of SIV-infected apoptotic cells, preventing the recruitment of CD4 + target T cells. The figure contains images (monkeys and immunogens) created in BioRender. Woode, E. (2025) https://BioRender.com/p4mqsnf . Correlations: b – d two-tailed Spearman correlation with simple linear regression. Alum animals and correlations are depicted in blue, ALFQA animals and correlations are depicted in red. Source data are provided as a Source Data file.
    Figure Legend Snippet: a Heatmap summarizing the significant two-tailed Spearman correlations between the absolute levels (pg/ml) of epidermal growth factor (EGF), Interleukin 17 F (IL-17F), C-C motif chemokine ligand 8 (CCL8), C-X-C motif chemokine ligand 8 (CXCL8), and lymphotoxin-alpha (LTA) measured in plasma collected at week 12 + 24 h from ALFQA ( n = 12) and alum ( n = 17) animals, and at week 13 from ALFQA ( n = 12) and alum ( n = 12) animals, and time of acquisition (TOA). The ρ-values are identified by the color-scale, while the significant correlations ( p < 0.05) are identified by asterisks. Reported p values are unadjusted for multiple comparisons. b , c Correlation of the absolute level (pg/ml) of plasma LTA at week 13 with b TOA in ALFQA ( n = 12) or alum ( n = 12) animals or c the vaccine-induced change (week 13 – baseline) of the frequency of rectal DC-10 in ALFQA ( n = 12) animals (paired data not available in alum-treated animals). d Correlations of the absolute level (pg/ml) of plasma CCL8 at week 12 + 24 h with TOA in alum ( n = 17) and ALFQA ( n = 12) animals. e Schematic representation of immune responses contributing to vaccine efficacy at the systemic and mucosal levels and their comparison between ALFQA (left) and Alum (right) groups. In peripheral blood, the immunization with ΔV1DNA/ALVAC and ΔV1gp120 protein boost adjuvanted in ALFQA induces antibodies to gp120 mediating ADCC, and, when compared to Alum, higher ADCP and ADNP, together with higher CD14 + efferocytes. In the ALFQA group, vaccination induces higher levels of LTA and other cytokines/chemokines. LTA in plasma induces mucosal tolerogenic DC-10, toward a protective phenotype. Together with increased anti-inflammatory CD73 + CD163 + macrophages and ILCs that express NKp44 + and maintain tissue-homeostasis, DC-10 favors the killing and clearance of SIV-infected apoptotic cells, preventing the recruitment of CD4 + target T cells. The figure contains images (monkeys and immunogens) created in BioRender. Woode, E. (2025) https://BioRender.com/p4mqsnf . Correlations: b – d two-tailed Spearman correlation with simple linear regression. Alum animals and correlations are depicted in blue, ALFQA animals and correlations are depicted in red. Source data are provided as a Source Data file.

    Techniques Used: Two Tailed Test, Clinical Proteomics, Comparison, Infection

    Related Articles

    Plasmid Preparation:

    Article Title: The repeated setbacks of HIV vaccine development laid the groundwork for SARS-CoV-2 vaccines
    Article Snippet: To help sort out why the Merck STEP vaccine failed, the RV144 trial, conducted by the U.S. Military HIV Research Program, tested a combination vaccine on over 16,400 supposedly HIV-negative volunteers in Thailand . .. The primer vaccine, based on a canarypox viral vector, a proprietary product acquired by Sanofi Pasteur named ALVAC, was administered at 0, 4, 12 and 24 weeks. ..

    Article Title: Receptor Binding Domain Based HIV Vaccines
    Article Snippet: .. One representative vaccine is the combination of AIDSVAX, as noted above, and Sanofi Pasteur's vector-based vaccine, ALVAC. ..

    other:

    Article Title: Ad hoc analysis of behavior and time as co-variates of the Thai phase III efficacy trial: RV 144
    Article Snippet: CONFLICT OF INTEREST STATEMENT Sanjay Gurunathan and Jim Tartaglia are employees of Sanofi-Pasteur, the commercial manufacturer of ALVAC.



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    a Heatmap summarizing the significant two-tailed Spearman correlations between the absolute levels (pg/ml) of epidermal growth factor (EGF), Interleukin 17 F (IL-17F), C-C motif chemokine ligand 8 (CCL8), C-X-C motif chemokine ligand 8 (CXCL8), and lymphotoxin-alpha (LTA) measured in plasma collected at week 12 + 24 h from ALFQA ( n = 12) and alum ( n = 17) animals, and at week 13 from ALFQA ( n = 12) and alum ( n = 12) animals, and time of acquisition (TOA). The ρ-values are identified by the color-scale, while the significant correlations ( p < 0.05) are identified by asterisks. Reported p values are unadjusted for multiple comparisons. b , c Correlation of the absolute level (pg/ml) of plasma LTA at week 13 with b TOA in ALFQA ( n = 12) or alum ( n = 12) animals or c the vaccine-induced change (week 13 – baseline) of the frequency of rectal DC-10 in ALFQA ( n = 12) animals (paired data not available in alum-treated animals). d Correlations of the absolute level (pg/ml) of plasma CCL8 at week 12 + 24 h with TOA in alum ( n = 17) and ALFQA ( n = 12) animals. e Schematic representation of immune responses contributing to vaccine efficacy at the systemic and mucosal levels and their comparison between ALFQA (left) and Alum (right) groups. In peripheral blood, the immunization with ΔV1DNA/ALVAC and ΔV1gp120 protein boost adjuvanted in ALFQA induces antibodies to gp120 mediating ADCC, and, when compared to Alum, higher ADCP and ADNP, together with higher CD14 + efferocytes. In the ALFQA group, vaccination induces higher levels of LTA and other cytokines/chemokines. LTA in plasma induces mucosal tolerogenic DC-10, toward a protective phenotype. Together with increased anti-inflammatory CD73 + CD163 + macrophages and ILCs that express NKp44 + and maintain tissue-homeostasis, DC-10 favors the killing and clearance of SIV-infected apoptotic cells, preventing the recruitment of CD4 + target T cells. The figure contains images (monkeys and immunogens) created in BioRender. Woode, E. (2025) https://BioRender.com/p4mqsnf . Correlations: b – d two-tailed Spearman correlation with simple linear regression. Alum animals and correlations are depicted in blue, ALFQA animals and correlations are depicted in red. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques

    doi: 10.1038/s41467-025-63610-z

    Figure Lengend Snippet: a Heatmap summarizing the significant two-tailed Spearman correlations between the absolute levels (pg/ml) of epidermal growth factor (EGF), Interleukin 17 F (IL-17F), C-C motif chemokine ligand 8 (CCL8), C-X-C motif chemokine ligand 8 (CXCL8), and lymphotoxin-alpha (LTA) measured in plasma collected at week 12 + 24 h from ALFQA ( n = 12) and alum ( n = 17) animals, and at week 13 from ALFQA ( n = 12) and alum ( n = 12) animals, and time of acquisition (TOA). The ρ-values are identified by the color-scale, while the significant correlations ( p < 0.05) are identified by asterisks. Reported p values are unadjusted for multiple comparisons. b , c Correlation of the absolute level (pg/ml) of plasma LTA at week 13 with b TOA in ALFQA ( n = 12) or alum ( n = 12) animals or c the vaccine-induced change (week 13 – baseline) of the frequency of rectal DC-10 in ALFQA ( n = 12) animals (paired data not available in alum-treated animals). d Correlations of the absolute level (pg/ml) of plasma CCL8 at week 12 + 24 h with TOA in alum ( n = 17) and ALFQA ( n = 12) animals. e Schematic representation of immune responses contributing to vaccine efficacy at the systemic and mucosal levels and their comparison between ALFQA (left) and Alum (right) groups. In peripheral blood, the immunization with ΔV1DNA/ALVAC and ΔV1gp120 protein boost adjuvanted in ALFQA induces antibodies to gp120 mediating ADCC, and, when compared to Alum, higher ADCP and ADNP, together with higher CD14 + efferocytes. In the ALFQA group, vaccination induces higher levels of LTA and other cytokines/chemokines. LTA in plasma induces mucosal tolerogenic DC-10, toward a protective phenotype. Together with increased anti-inflammatory CD73 + CD163 + macrophages and ILCs that express NKp44 + and maintain tissue-homeostasis, DC-10 favors the killing and clearance of SIV-infected apoptotic cells, preventing the recruitment of CD4 + target T cells. The figure contains images (monkeys and immunogens) created in BioRender. Woode, E. (2025) https://BioRender.com/p4mqsnf . Correlations: b – d two-tailed Spearman correlation with simple linear regression. Alum animals and correlations are depicted in blue, ALFQA animals and correlations are depicted in red. Source data are provided as a Source Data file.

    Article Snippet: All twelve macaques were then boosted twice (weeks 8 and 12) with intramuscular inoculations of 10 8 plaque-forming units (PFU) of recombinant ALVAC (vCP2432), expressing SIV mac251 gag-pro and gp120TM (Sanofi Pasteur, Bridgewater, NJ).

    Techniques: Two Tailed Test, Clinical Proteomics, Comparison, Infection