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afatinib  (MedChemExpress)


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    MedChemExpress afatinib
    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
    Afatinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 64 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/afatinib/pmc13122707-42-0-7?v=MedChemExpress
    Average 94 stars, based on 64 article reviews
    afatinib - by Bioz Stars, 2026-07
    94/100 stars

    Images

    1) Product Images from "C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC"

    Article Title: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC

    Journal: Redox Biology

    doi: 10.1016/j.redox.2026.104172

    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), Afatinib (1 μM) (E), Osimertinib (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
    Figure Legend Snippet: IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), Afatinib (1 μM) (E), Osimertinib (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.

    Techniques Used: Over Expression, Expressing, Western Blot, Control



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    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
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    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
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    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
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    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
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    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
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    Image Search Results


    IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), Afatinib (1 μM) (E), Osimertinib (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.

    Journal: Redox Biology

    Article Title: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC

    doi: 10.1016/j.redox.2026.104172

    Figure Lengend Snippet: IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), Afatinib (1 μM) (E), Osimertinib (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.

    Article Snippet: Afatinib, osimertinib and silivertinib (BDTX-1535) were from MedchemExpress (NJ, USA).

    Techniques: Over Expression, Expressing, Western Blot, Control