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hy y1750 hy 10409a  (MedChemExpress)


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    MedChemExpress hy y1750 hy 10409a
    Hy Y1750 Hy 10409a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 367 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 96 stars, based on 367 article reviews
    hy y1750 hy 10409a - by Bioz Stars, 2026-02
    96/100 stars

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    Inhibition of endothelial LOX/LOXL2 protects mesangial cells from high glucose-induced damage. (a–c) Suppression of mesangial cell proliferation and viability by conditioned media from HG-exposed GEnCs treated with BAPN (HG + BAPN-CM) or PAT-1251 (HG + PAT-1251-CM), compared to damaging HG-CM. n = 5. (d,e) Attenuation of HG-CM-induced lipid peroxidation and protein carbonylation in mesangial cells by endothelial LOX/LOXL2 inhibition. n = 5. (f,g) Suppression of fibrotic gene expression (FN1, Col4a1) in mesangial cells exposed to inhibitor-treated CM. n = 5. (h,i) Reduced collagen deposition in mesangial cells treated with BAPN-CM or PAT-1251-CM vs. HG-CM. n = 5. * p < 0.05, ** p < 0.01, *** p < 0.001. Error bars indicate SD.

    Journal: Redox Report : Communications in Free Radical Research

    Article Title: Verbascoside targets endothelial HIF-1α/ Lysyl oxidase signaling to attenuate glomerular injury in diabetic nephropathy

    doi: 10.1080/13510002.2025.2598110

    Figure Lengend Snippet: Inhibition of endothelial LOX/LOXL2 protects mesangial cells from high glucose-induced damage. (a–c) Suppression of mesangial cell proliferation and viability by conditioned media from HG-exposed GEnCs treated with BAPN (HG + BAPN-CM) or PAT-1251 (HG + PAT-1251-CM), compared to damaging HG-CM. n = 5. (d,e) Attenuation of HG-CM-induced lipid peroxidation and protein carbonylation in mesangial cells by endothelial LOX/LOXL2 inhibition. n = 5. (f,g) Suppression of fibrotic gene expression (FN1, Col4a1) in mesangial cells exposed to inhibitor-treated CM. n = 5. (h,i) Reduced collagen deposition in mesangial cells treated with BAPN-CM or PAT-1251-CM vs. HG-CM. n = 5. * p < 0.05, ** p < 0.01, *** p < 0.001. Error bars indicate SD.

    Article Snippet: The pan lysyl oxidase inhibitor β-aminoproprionitrile (BAPN) (Cat. No. HY-Y1750), LOXL2 inhibitor PAT-1251 (Cat. No. HY-107422), and HIF-1 inhibitor (Cat. No. BAY 87-2243) were obtained from MedChemExpress.

    Techniques: Inhibition, Gene Expression